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AROF_SOLTU
ID   AROF_SOLTU              Reviewed;         538 AA.
AC   P21357;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic;
DE            EC=2.5.1.54;
DE   AltName: Full=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 1;
DE   AltName: Full=DAHP synthase 1;
DE   AltName: Full=Phospho-2-keto-3-deoxyheptonate aldolase 1;
DE   Flags: Precursor;
GN   Name=SHKA; Synonyms=ARO1;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=cv. Superior;
RX   PubMed=1967256; DOI=10.1016/s0021-9258(19)40060-4;
RA   Dyer W.E., Weaver L.M., Zhao J., Kuhn D.N., Weller S.C., Herrmann K.M.;
RT   "A cDNA encoding 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from
RT   Solanum tuberosum L.";
RL   J. Biol. Chem. 265:1608-1614(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC   -!- ACTIVITY REGULATION: Activation by tryptophan (a hysteretic factor).
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
CC   -!- INDUCTION: By the herbicide glyphosate and wounding.
CC   -!- SIMILARITY: Belongs to the class-II DAHP synthase family.
CC       {ECO:0000305}.
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DR   EMBL; J05191; AAA33810.1; ALT_SEQ; mRNA.
DR   PIR; A35016; A35016.
DR   AlphaFoldDB; P21357; -.
DR   SMR; P21357; -.
DR   STRING; 4113.PGSC0003DMT400079161; -.
DR   eggNOG; ENOG502QPP7; Eukaryota.
DR   InParanoid; P21357; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; P21357; baseline.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002480; DAHP_synth_2.
DR   PANTHER; PTHR21337; PTHR21337; 1.
DR   Pfam; PF01474; DAHP_synth_2; 1.
DR   TIGRFAMs; TIGR01358; DAHP_synth_II; 1.
PE   1: Evidence at protein level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Chloroplast;
KW   Direct protein sequencing; Plastid; Reference proteome; Transferase;
KW   Transit peptide.
FT   TRANSIT         1..74
FT                   /note="Chloroplast"
FT   CHAIN           75..538
FT                   /note="Phospho-2-dehydro-3-deoxyheptonate aldolase 1,
FT                   chloroplastic"
FT                   /id="PRO_0000002302"
FT   REGION          55..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         75
FT                   /note="Blocked amino end (Thr)"
SQ   SEQUENCE   538 AA;  59668 MW;  9088EDF97CA14B13 CRC64;
     MALSSTSTTN SLLPNRSLVQ NQPLLPSPLK NAFFSNNSTK TVRFVQPISA VHSSDSNKIP
     IVSDKPSKSS PPAATATTAP APAVTKTEWA VDSWKSKKAL QLPEYPNQEE LRSVLKTIDE
     FPPIVFAGEA RSLEERLGEA AMGRAFLLQG GDCAESFKEF NANNIRDTFR ILLQMGAVLM
     FGGQMPVIKV GRMAGQFAKP RSDSFEEKDG VKLPSYRGDN VNGDAFDVKS RTPDPQRLIR
     AYCQSAATLN LLRAFATGGY AAMQRINQWN LDFTEHSEQG DRYRELASRV DEALGFMTAA
     GLTMDHPIMK TTEFWTSHEC LLLPYEQSLT RRDSTSGLYY DCSAHFLWVG ERTRQLDGAH
     VEFLRGIANP LGIKVSDKMD PSALVKLIEI LNPQNKAGRI TIITRMGAEN MRVKLPHLIR
     AVRRAGQIVT WVSDPMHGNT IKAPCGLKTR PFDSIRAEVR AFFDVHDQEG SHPGGVHLEM
     TGQNVTECIG GSRTVTFDDL SSRYHTHCDP RLNASQSLEL SFIIAERLRK RRLGSQSV
 
 
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