ID   NQRA_RHOBA              Reviewed;         456 AA.
AC   Q7UWS5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=RB1831;
OS   Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC   Bacteria; Planctomycetes; Planctomycetia; Pirellulales; Pirellulaceae;
OC   Rhodopirellula.
OX   NCBI_TaxID=243090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX   PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA   Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA   Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA   Reinhardt R.;
RT   "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT   1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAD72287.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX294135; CAD72287.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_864606.1; NC_005027.1.
DR   AlphaFoldDB; Q7UWS5; -.
DR   SMR; Q7UWS5; -.
DR   STRING; 243090.RB1831; -.
DR   EnsemblBacteria; CAD72287; CAD72287; RB1831.
DR   KEGG; rba:RB1831; -.
DR   PATRIC; fig|243090.15.peg.840; -.
DR   eggNOG; COG1726; Bacteria.
DR   HOGENOM; CLU_046656_0_0_0; -.
DR   InParanoid; Q7UWS5; -.
DR   OrthoDB; 688908at2; -.
DR   Proteomes; UP000001025; Chromosome.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW   Translocase; Transport; Ubiquinone.
FT   CHAIN           1..456
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_0000227020"
SQ   SEQUENCE   456 AA;  49195 MW;  4B016F907FF0FB47 CRC64;
     MATTQSVTRI KKGLDLPITG CPEQHMEAGP AIRQVALLGD DYIGMKPTML VSAGDRVVLG
     QPVFEDKKTP GVIYTAPASG TVVDVVRGAK RKFEAVVIDV DNDSTETTTI DGIAGSDPIS
     IAREKLVDGL VQIGLWSAFR TRPFGKVPTI ESRPHSIFVT AIDTNPLAAD PAVVLADRKD
     QFVIGLQALT RLTDGAVHLC QAEKASIPGG DVAGVQSASF AGPHPAGLPG THIHHLDPVS
     LNKTVWYIGY QDVIAIGSFL QTGQLDTRRV ISLAGPKVNQ PRLIETRLGA CIDELIDGEV
     DTSVKLRVIS GSVLNGHIAT APHQFLGRYD NQVSVIEEGD HREFLGWQKP GFDKFSVSRI
     FASAMTPDRK FDFTSSTGGS ERAMVPLGTY EKVMPMDILA TQLLRALIVR DTDSAQQLGV
     LELEEEDLAL CTFVCPGKYE YGSLIRENLT TIEREG