AROF_STRCO
ID AROF_STRCO Reviewed; 450 AA.
AC P80574; Q9S2M8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase;
DE EC=2.5.1.54;
DE AltName: Full=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase;
DE AltName: Full=DAHP synthase;
DE AltName: Full=Phospho-2-keto-3-deoxyheptonate aldolase;
GN Name=aroH; OrderedLocusNames=SCO2115; ORFNames=SC6E10.09c;
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145;
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
RN [2]
RP PROTEIN SEQUENCE OF 2-22, AND CHARACTERIZATION.
RC STRAIN=A3(2) / NRRL B-16638;
RX PubMed=8760910; DOI=10.1099/13500872-142-8-1973;
RA Walker G.E., Dunbar B., Hunter I.S., Nimmo H.G., Coggins J.R.;
RT "Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-
RT phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus
RT and Neurospora crassa.";
RL Microbiology 142:1973-1982(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC 1/7.
CC -!- SUBUNIT: Homodimer.
CC -!- SIMILARITY: Belongs to the class-II DAHP synthase family.
CC {ECO:0000305}.
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DR EMBL; AL939111; CAB51963.1; -; Genomic_DNA.
DR PIR; T35496; T35496.
DR RefSeq; NP_626372.1; NC_003888.3.
DR RefSeq; WP_003976701.1; NZ_VNID01000001.1.
DR AlphaFoldDB; P80574; -.
DR SMR; P80574; -.
DR STRING; 100226.SCO2115; -.
DR PRIDE; P80574; -.
DR GeneID; 1097549; -.
DR KEGG; sco:SCO2115; -.
DR PATRIC; fig|100226.15.peg.2149; -.
DR eggNOG; COG3200; Bacteria.
DR HOGENOM; CLU_026885_0_1_11; -.
DR InParanoid; P80574; -.
DR OMA; WNQDFVK; -.
DR PhylomeDB; P80574; -.
DR UniPathway; UPA00053; UER00084.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.70; -; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002480; DAHP_synth_2.
DR PANTHER; PTHR21337; PTHR21337; 1.
DR Pfam; PF01474; DAHP_synth_2; 1.
DR TIGRFAMs; TIGR01358; DAHP_synth_II; 1.
PE 1: Evidence at protein level;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW Direct protein sequencing; Reference proteome; Transferase.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8760910"
FT CHAIN 2..450
FT /note="Phospho-2-dehydro-3-deoxyheptonate aldolase"
FT /id="PRO_0000140854"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 15..22
FT /note="WRDLPAAQ -> DDPLQAPS (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 450 AA; 49870 MW; 074668C290250874 CRC64;
MTVNAKTSPS AGNTWRDLPA AQQPEYPDTE ALRAVIADLE SYPPLVFAGE CDQLRARMAA
VAKGEAFLLQ GGDCAEAFDA VSADHIRNKL KTLLQMGAVL TYAASVPVVK VGRIAGQYSK
PRSKPTETRD GVTLPTYRGD SVNGFDFTEA ARIPDPERLK RMYHASASTL NLVRAFTTGG
YADLRQVHAW NQDFVKSSPS GQRYEQLARE IDNALNFMRA CGTDPAEFQT VEFFSSHEAL
LLDYESALTR VDSRTGQLYD VSGHMVWIGE RTRQLDHAHI EFASRIRNPI GIKLGPSTTA
EEALQYIERL DPEREPGRLT FIVRMGADKI RDKLPELVEK VTASGATVAW ITDPMHGNTY
EAASGHKTRR FDDVLDEVKG FFEVHKSLGT HPGGIHVELT GDDVTECVGG GDEIFVDDLH
QRYETACDPR LNRSQSLDLA FLVAEMYRDQ
