ID   NQRA_VIBAN              Reviewed;         446 AA.
AC   Q75R64;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425};
OS   Vibrio anguillarum (Listonella anguillarum).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=55601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Fujiwara-Nagata E., Eguchi Y., Utsumi R., Eguchi M.;
RT   "Cloning, sequencing and transcriptional regulation of Na+-dependent
RT   NADH:quinone oxidoreductase gene of Vibrio anguillarum, a fish pathogen.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD14948.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB159077; BAD14948.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q75R64; -.
DR   SMR; Q75R64; -.
DR   STRING; 55601.VANGNB10_cI2081c; -.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW   Ubiquinone.
FT   CHAIN           1..446
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_0000214204"
SQ   SEQUENCE   446 AA;  48655 MW;  EC7820E336A08197 CRC64;
     MITIKRGLDL PIAGTPSQVI NDGKTITKVA LLGEEYVGMR PTMHVRVGDE VKKAQILFED
     KKNPGVKFTS PASGKVIEVN RGAKRVLQSV VIEVAGDEQI TFDSFEASQL ASIDRQTVKT
     QLVESGLWTA LRTRPFSKVP AIESSTQAIF VTAMDTNPLA AKPETIINEQ SEAFVAGLDI
     LSTLTEGKVY VCKSGTSLPR SSQPNVEEHV FDGPHPAGLV GTHMHFLYPV NAVNVAWSIN
     YQDVIAFGQL FLTGELYTQR VVSLAGPVVN KPRLVRTQIG ASLEELTDNE LMPGEVRVIS
     GSVLSGVKAA GPVAYLGRYH LQVSVLREGR DKDFLGWAMP GKNKFSVTRS FLGHLFTGQL
     FNMTTTTNGS DRAMVPIGNY EKVLPLDMEP TLLLRDLCAG DIDSAQRLGA LELDEEDLAL
     CTFVCPGKYE YGQLLRECLD KIEKEG