ID   NQRA_VIBC1              Reviewed;         446 AA.
AC   Q9RFW1; A7N1U6;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE   AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN   Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425};
GN   OrderedLocusNames=VIBHAR_03275;
OS   Vibrio campbellii (strain ATCC BAA-1116).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=2902295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10587447; DOI=10.1021/bi991664s;
RA   Zhou W., Bertsova Y.V., Feng B., Tsatsos P., Verkhovskaya M.L.,
RA   Gennis R.B., Bogachev A.V., Barquera B.;
RT   "Sequencing and preliminary characterization of the Na+-translocating
RT   NADH:ubiquinone oxidoreductase from Vibrio harveyi.";
RL   Biochemistry 38:16246-16252(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1116 / BB120;
RG   The Vibrio harveyi Genome Sequencing Project;
RA   Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C.,
RA   Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K.,
RA   Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J.,
RA   Wilson R.K.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00425};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC   -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00425}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABU72223.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF165980; AAF15411.1; -; Genomic_DNA.
DR   EMBL; CP000789; ABU72223.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041853286.1; NC_022269.1.
DR   AlphaFoldDB; Q9RFW1; -.
DR   SMR; Q9RFW1; -.
DR   EnsemblBacteria; ABU72223; ABU72223; VIBHAR_03275.
DR   KEGG; vha:VIBHAR_03275; -.
DR   PATRIC; fig|338187.36.peg.3202; -.
DR   OrthoDB; 688908at2; -.
DR   Proteomes; UP000008152; Chromosome I.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00425; NqrA; 1.
DR   InterPro; IPR008703; NqrA.
DR   InterPro; IPR022615; NqrA_C_domain.
DR   PANTHER; PTHR37839; PTHR37839; 1.
DR   Pfam; PF05896; NQRA; 1.
DR   Pfam; PF11973; NQRA_SLBB; 1.
DR   TIGRFAMs; TIGR01936; nqrA; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW   Ubiquinone.
FT   CHAIN           1..446
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   A"
FT                   /id="PRO_0000214206"
SQ   SEQUENCE   446 AA;  48365 MW;  9B05B38BB1D7A97C CRC64;
     MITIKKGLAL PIAGAPSQVI NDGKTIKKVA LLGEEYVGMR PTMHVRVGDE VKKAQVLFED
     KKNPGVKFTA PAAGKVIEIN RGAKRVLQSV VIEVAGEEQV TFDKFEAAQL AGLDREVIKT
     QLVESGLWTA LRTRPFSKVP AIESATKAIF VTAMDTNPLA AQPELIITEQ QEAFVAGLDI
     LSALTEGKVY VCKSGTSLPS SSQSNVEEHV FDGPHPAGLA GTHMHFLYPV NAENVAWSIN
     YQDVIAFGQL FLTGELYTDR VVSLAGPVVN NPRLLRTVVG ASLEDLTDSE LMPGEVRVIS
     GSVLSGTQAS GPHAYLGRYH QQVSVLREGR DKELFGWATP GKNKFSITKS FLGHIFKGQL
     FNMTTTTNGS DRAMVPIGNY ERVMPLDMEP TLLLRDLCAG DTDSAQTLGA LELDEEDLAL
     CTFVCPGKYE YGQLLRECLD TIVKEG