NQRA_VIBVU
ID NQRA_VIBVU Reviewed; 446 AA.
AC Q8DBJ6;
DT 30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 30-APR-2003, sequence version 2.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=VV1_1821;
OS Vibrio vulnificus (strain CMCP6).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=216895;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMCP6;
RA Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00425};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00425}.
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DR EMBL; AE016795; AAO10227.2; -; Genomic_DNA.
DR RefSeq; WP_011079727.1; NC_004459.3.
DR AlphaFoldDB; Q8DBJ6; -.
DR SMR; Q8DBJ6; -.
DR EnsemblBacteria; AAO10227; AAO10227; VV1_1821.
DR KEGG; vvu:VV1_1821; -.
DR HOGENOM; CLU_046656_0_0_6; -.
DR OMA; IKQRPYD; -.
DR Proteomes; UP000002275; Chromosome 1.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00425; NqrA; 1.
DR InterPro; IPR008703; NqrA.
DR InterPro; IPR022615; NqrA_C_domain.
DR PANTHER; PTHR37839; PTHR37839; 1.
DR Pfam; PF05896; NQRA; 1.
DR Pfam; PF11973; NQRA_SLBB; 1.
DR TIGRFAMs; TIGR01936; nqrA; 1.
PE 3: Inferred from homology;
KW Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW Ubiquinone.
FT CHAIN 1..446
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT A"
FT /id="PRO_0000214208"
SQ SEQUENCE 446 AA; 48538 MW; 94A9645856DAF6AA CRC64;
MITIKKGLDL PIAGAPSQVI NDGKSITKVA LLGEEYVGMR PTMHVRVGDE VKKAQVLFED
KKNPGVKFTS PVSGKVIEVN RGAKRVLQSV VIEVAGDEQV TFDKFEASQL AGLDREVIKT
QLVESGLWTA LRTRPFSKVP AIESTTKAIF VTAMDTNPLA AKPELIINEQ AEAFVAGLDV
LSALTEEKVY VCKSGTSLPR SSQSNVEEHV FDGPHPAGLA GTHMHFLYPV NANNVAWSIN
YQDVIAFGQL FLTGELFTDR VVSLAGPVVN NPRLVRTIMG ASLDELTDSE MMPGEVRVIS
GSVLTGTHAT GPHAYLGRYH LQVSVLREGR DKELFGWATP GKNKFSVTRS FLGHLFKGQL
FNMTTTTNGS DRAMVPIGNY ERVVPLDMEP TLLLRDLCAG DTDSAQALGA LELDEEDLAL
CTFVCPGKYE YGQLLRDCLN TIEKEG