NQRA_YERE8
ID NQRA_YERE8 Reviewed; 447 AA.
AC A1JNZ8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=YE3220;
OS Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS 8081).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=393305;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 13174 / 8081;
RX PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA Prentice M.B.;
RT "The complete genome sequence and comparative genome analysis of the high
RT pathogenicity Yersinia enterocolitica strain 8081.";
RL PLoS Genet. 2:2039-2051(2006).
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00425};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00425}.
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DR EMBL; AM286415; CAL13252.1; -; Genomic_DNA.
DR RefSeq; WP_011816936.1; NC_008800.1.
DR RefSeq; YP_001007396.1; NC_008800.1.
DR AlphaFoldDB; A1JNZ8; -.
DR SMR; A1JNZ8; -.
DR STRING; 393305.YE3220; -.
DR EnsemblBacteria; CAL13252; CAL13252; YE3220.
DR KEGG; yen:YE3220; -.
DR PATRIC; fig|393305.7.peg.3424; -.
DR eggNOG; COG1726; Bacteria.
DR HOGENOM; CLU_046656_0_0_6; -.
DR OMA; IKQRPYD; -.
DR Proteomes; UP000000642; Chromosome.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00425; NqrA; 1.
DR InterPro; IPR008703; NqrA.
DR InterPro; IPR022615; NqrA_C_domain.
DR PANTHER; PTHR37839; PTHR37839; 1.
DR Pfam; PF05896; NQRA; 1.
DR Pfam; PF11973; NQRA_SLBB; 1.
DR TIGRFAMs; TIGR01936; nqrA; 1.
PE 3: Inferred from homology;
KW Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW Ubiquinone.
FT CHAIN 1..447
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT A"
FT /id="PRO_1000060131"
SQ SEQUENCE 447 AA; 49222 MW; DE70B17CFAB8A1E3 CRC64;
MIKIKKGLNL PIAGAPVQVI EEGPDIHYVA LLGEEYVGMR PSMLVQEGDW VKKGQALFED
KKNPGVMFTA PASGKVSAIN RGERRVLQSV VIEIDGDEQV PFEHYEESSL NQLSDEQVQR
HLLASGLWTA LRTRPFSKTP VPNSRPRAIF ISAMDTQPLA ADPQVIIATE SEAFNHGLTI
LARLTEGKVH VCHAPGQAVA SYQNAQVTYN EFSGPHPAGL VGTHIHFLEP VSLNKTVWHV
GYQDVIAIGK LFTRGELWTD RIVSLAGPQV EQPVLLRTRL GASLSELTTG RLKEGDNRII
SGSVLSGTAF SATHGYLGRF HQQVSVIREG REKELFGWVM PGRDKYSITR TTLGHFFKHK
LFAFSTDMHG GERAMVPIGN YERVMPLDIL ATHLLRDLLA GDTDSAAALG CLELDEEDLA
LCTFVCPGKY EYGPVLRDIL TKIEQEG