NQRA_YERP3
ID NQRA_YERP3 Reviewed; 447 AA.
AC A7FLJ8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425};
GN OrderedLocusNames=YpsIP31758_3166;
OS Yersinia pseudotuberculosis serotype O:1b (strain IP 31758).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=349747;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP 31758;
RX PubMed=17784789; DOI=10.1371/journal.pgen.0030142;
RA Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G.,
RA Fayolle C., Lindler L.E., Carniel E., Ravel J.;
RT "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the
RT causative agent of Far East scarlet-like fever.";
RL PLoS Genet. 3:1508-1523(2007).
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00425};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00425}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000720; ABS49848.1; -; Genomic_DNA.
DR RefSeq; WP_012105597.1; NC_009708.1.
DR AlphaFoldDB; A7FLJ8; -.
DR SMR; A7FLJ8; -.
DR EnsemblBacteria; ABS49848; ABS49848; YpsIP31758_3166.
DR KEGG; ypi:YpsIP31758_3166; -.
DR HOGENOM; CLU_046656_0_0_6; -.
DR OMA; IKQRPYD; -.
DR Proteomes; UP000002412; Chromosome.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00425; NqrA; 1.
DR InterPro; IPR008703; NqrA.
DR InterPro; IPR022615; NqrA_C_domain.
DR PANTHER; PTHR37839; PTHR37839; 1.
DR Pfam; PF05896; NQRA; 1.
DR Pfam; PF11973; NQRA_SLBB; 1.
DR TIGRFAMs; TIGR01936; nqrA; 1.
PE 3: Inferred from homology;
KW Ion transport; NAD; Sodium; Sodium transport; Translocase; Transport;
KW Ubiquinone.
FT CHAIN 1..447
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT A"
FT /id="PRO_1000060132"
SQ SEQUENCE 447 AA; 48944 MW; C3DD4C8541CCE809 CRC64;
MIKIKKGLDL PIAGAPVQTI QDGPAIHHVA LLGEEYVGMR PSMLVQEGDQ VKKGQALFED
KKNPGVLFTA PASGKISAIN RGERRVLQSV VIEVEGDEQI PFEHYAAEEL NQLSDEQVQH
HLLTSGLWTA LRTRPFSKTP VPGSRPRAIF ISAMDTQPLA ADPQVIIATE SEAFNHGLTV
LTRLTDGKVH VCHAAGQAVT RHTNTQVTYN EFSGPHPAGL VGTHIHFLEP VSQTKMVWHV
GYQDVIAIGK LFTRGELCTD RIVALAGPQV NQPILLRTRL GASLSGLTAG KLKEGDNRII
SGSVLSGTAF SATHGYLGRF HQQVSVIREG REKELFGWVM PGRDKYSITR TTLGHFFKRK
LFAFSTDMHG GERAMVPIGN YERVMPLDIL ATHLLRDLLA GDTDSAQALG CLELDEEDLA
LCTFVCPGKY EYGPVLRDIL TQIEQEG