ID   AROF_STRRM              Reviewed;          18 AA.
AC   P80575;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase;
DE            EC=2.5.1.54;
DE   AltName: Full=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase;
DE   AltName: Full=DAHP synthase;
DE   AltName: Full=Phospho-2-keto-3-deoxyheptonate aldolase;
DE   Flags: Fragment;
GN   Name=aroH;
OS   Streptomyces rimosus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1927;
RN   [1]
RP   PROTEIN SEQUENCE, AND CHARACTERIZATION.
RC   STRAIN=Isolate 4018;
RX   PubMed=8760910; DOI=10.1099/13500872-142-8-1973;
RA   Walker G.E., Dunbar B., Hunter I.S., Nimmo H.G., Coggins J.R.;
RT   "Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-
RT   phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus
RT   and Neurospora crassa.";
RL   Microbiology 142:1973-1982(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the class-II DAHP synthase family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P80575; -.
DR   UniPathway; UPA00053; UER00084.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
PE   1: Evidence at protein level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Direct protein sequencing; Transferase.
FT   CHAIN           <1..>18
FT                   /note="Phospho-2-dehydro-3-deoxyheptonate aldolase"
FT                   /id="PRO_0000140855"
FT   NON_TER         1
FT   NON_TER         18
SQ   SEQUENCE   18 AA;  2209 MW;  7FE627E713C871BB CRC64;
     TRRFDDVLDE VKGFFEVH