ID   AROF_TOBAC              Reviewed;         542 AA.
AC   P27608;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic;
DE            EC=2.5.1.54;
DE   AltName: Full=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 1;
DE   AltName: Full=DAHP synthase 1;
DE   AltName: Full=Phospho-2-keto-3-deoxyheptonate aldolase 1;
DE   Flags: Precursor;
GN   Name=DHAPS-1;
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Wisconsin 38;
RX   PubMed=16668482; DOI=10.1104/pp.97.2.847;
RA   Wang Y., Herrmann K.M., Weller S.C., Goldsbrough P.B.;
RT   "Cloning and nucleotide sequence of a complementary DNA encoding 3-deoxy-D-
RT   arabino-heptulosonate 7-phosphate synthase from tobacco.";
RL   Plant Physiol. 97:847-848(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC   -!- ACTIVITY REGULATION: Activation by tryptophan (a hysteretic factor).
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
CC   -!- TISSUE SPECIFICITY: Leaves, stems, and petals.
CC   -!- INDUCTION: By the herbicide glyphosate and wounding.
CC   -!- SIMILARITY: Belongs to the class-II DAHP synthase family.
CC       {ECO:0000305}.
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DR   EMBL; M64261; AAA34068.1; -; mRNA.
DR   RefSeq; NP_001312132.1; NM_001325203.1.
DR   AlphaFoldDB; P27608; -.
DR   SMR; P27608; -.
DR   STRING; 4097.P27608; -.
DR   PRIDE; P27608; -.
DR   ProMEX; P27608; -.
DR   GeneID; 107775732; -.
DR   KEGG; nta:107775732; -.
DR   OMA; VEHPIMK; -.
DR   PhylomeDB; P27608; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002480; DAHP_synth_2.
DR   PANTHER; PTHR21337; PTHR21337; 1.
DR   Pfam; PF01474; DAHP_synth_2; 1.
DR   TIGRFAMs; TIGR01358; DAHP_synth_II; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Chloroplast;
KW   Plastid; Reference proteome; Transferase; Transit peptide.
FT   TRANSIT         1..76
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000250"
FT   CHAIN           77..542
FT                   /note="Phospho-2-dehydro-3-deoxyheptonate aldolase 1,
FT                   chloroplastic"
FT                   /id="PRO_0000002304"
FT   REGION          54..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   542 AA;  59975 MW;  4C166391ADBA7D51 CRC64;
     MALSSSSTTN SLLPNKSQLV QNQSLLPSPL KNVSFTTNST KPVRFVQPIS AIHSSDSSKN
     PIVSDKPSSK PSPPAATVTA AATTVTKTEW TVESWKSKKA LQLPEYPNQE ELQSVLKTIE
     EFPPIVFAGE ARSLEERLGE AAMGRAFLLQ GGDCAESFKE FNANNIRDTF RILLQMGAVL
     MFGGQMPVIK VGRMAGQFAK PRSDNFEEKN GVKLPSYRGD NVNGDAFDAK SRTPDPQRLI
     RAYCQSAATL NLLRAFATGG YAAMQRINQW NLDFTEHSEQ GDRYRELANR VDEALGFMAA
     AGLTVDHPIM KTTEFWTSHE CLLLPYEQSL TRLDSTSGLY YDCSAHFIWV GERTRQLDGA
     HVEFLRGVAN PLGIKVSDKM DPSALVKLIE ILNPDNKAGR ITIITRMGAE NMRVKLPHLI
     RAVRRAGQIV TWVSDPMHGN TIKAPCGLKT RPFDSIRAEV RAFFDVHEQE GSHPGGVHLE
     MTGQNVTECI GGSRTVTFDD LSSRYHTHCD PRLNASQSLE LAFIIAERLR KRRLGSQNVL
     GQ