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NQRD_CHLFF
ID   NQRD_CHLFF              Reviewed;         213 AA.
AC   Q253X2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Na(+)-translocating NADH-quinone reductase subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE            Short=Na(+)-NQR subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE            Short=Na(+)-translocating NQR subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE            EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00428};
DE   AltName: Full=NQR complex subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE   AltName: Full=NQR-1 subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
GN   Name=nqrD {ECO:0000255|HAMAP-Rule:MF_00428}; OrderedLocusNames=CF0644;
OS   Chlamydia felis (strain Fe/C-56) (Chlamydophila felis).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=264202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fe/C-56;
RX   PubMed=16766509; DOI=10.1093/dnares/dsi027;
RA   Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H.,
RA   Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H.,
RA   Hattori M., Kuhara S., Shirai M.;
RT   "Genome sequence of the cat pathogen, Chlamydophila felis.";
RL   DNA Res. 13:15-23(2006).
CC   -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC       ubiquinol by two successive reactions, coupled with the transport of
CC       Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC       probably involved in the second step, the conversion of ubisemiquinone
CC       to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00428}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC         Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00428};
CC   -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC       NqrF. {ECO:0000255|HAMAP-Rule:MF_00428}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00428}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00428}.
CC   -!- SIMILARITY: Belongs to the NqrDE/RnfAE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00428}.
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DR   EMBL; AP006861; BAE81416.1; -; Genomic_DNA.
DR   RefSeq; WP_011458195.1; NC_007899.1.
DR   AlphaFoldDB; Q253X2; -.
DR   SMR; Q253X2; -.
DR   STRING; 264202.CF0644; -.
DR   KEGG; cfe:CF0644; -.
DR   eggNOG; COG1347; Bacteria.
DR   HOGENOM; CLU_046659_1_1_0; -.
DR   OMA; CIIMGRF; -.
DR   OrthoDB; 1782047at2; -.
DR   Proteomes; UP000001260; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00428; NqrD; 1.
DR   InterPro; IPR011292; NqrD.
DR   InterPro; IPR003667; NqrDE/RnfAE.
DR   PANTHER; PTHR30586:SF1; PTHR30586:SF1; 1.
DR   Pfam; PF02508; Rnf-Nqr; 1.
DR   PIRSF; PIRSF006102; NQR_DE; 1.
DR   TIGRFAMs; TIGR01939; nqrD; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; NAD; Sodium;
KW   Sodium transport; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..213
FT                   /note="Na(+)-translocating NADH-quinone reductase subunit
FT                   D"
FT                   /id="PRO_1000060150"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
SQ   SEQUENCE   213 AA;  23446 MW;  E8856DC63CE98CA5 CRC64;
     MADNKPYKSY FLDPLWNNNQ PLIAILGICS ALAVTTTVKT AITMGLAVSF VTGCSSFFVS
     LLRKITPDSV RMITQLIIIS LFVIVIDQFL KAFFFNISKT LSVFVGLIIT NCIVMGRAES
     LARNVPPIPA FLDGLASGLG YGWVLVFVSI IREFFGFGTL LGLQLIPKCF YASEAHPDGY
     ENFGLMVLAP SAFFLLGIMI WVVNILRSKK AKR
 
 
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