NQRD_CHLTA
ID NQRD_CHLTA Reviewed; 213 AA.
AC Q3KM82;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE Short=Na(+)-NQR subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE Short=Na(+)-translocating NQR subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00428};
DE AltName: Full=NQR complex subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE AltName: Full=NQR-1 subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
GN Name=nqrD {ECO:0000255|HAMAP-Rule:MF_00428}; OrderedLocusNames=CTA_0302;
OS Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=315277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-571B / DSM 19440 / HAR-13;
RX PubMed=16177312; DOI=10.1128/iai.73.10.6407-6418.2005;
RA Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.;
RT "Comparative genomic analysis of Chlamydia trachomatis oculotropic and
RT genitotropic strains.";
RL Infect. Immun. 73:6407-6418(2005).
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00428}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00428};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00428}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00428}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00428}.
CC -!- SIMILARITY: Belongs to the NqrDE/RnfAE family. {ECO:0000255|HAMAP-
CC Rule:MF_00428}.
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DR EMBL; CP000051; AAX50540.1; -; Genomic_DNA.
DR RefSeq; WP_009872522.1; NC_007429.1.
DR AlphaFoldDB; Q3KM82; -.
DR SMR; Q3KM82; -.
DR EnsemblBacteria; AAX50540; AAX50540; CTA_0302.
DR KEGG; cta:CTA_0302; -.
DR HOGENOM; CLU_046659_1_1_0; -.
DR OMA; CIIMGRF; -.
DR Proteomes; UP000002532; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00428; NqrD; 1.
DR InterPro; IPR011292; NqrD.
DR InterPro; IPR003667; NqrDE/RnfAE.
DR PANTHER; PTHR30586:SF1; PTHR30586:SF1; 1.
DR Pfam; PF02508; Rnf-Nqr; 1.
DR PIRSF; PIRSF006102; NQR_DE; 1.
DR TIGRFAMs; TIGR01939; nqrD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane; NAD; Sodium;
KW Sodium transport; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..213
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT D"
FT /id="PRO_1000060151"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
SQ SEQUENCE 213 AA; 23269 MW; 766899F16EBB8728 CRC64;
MTTNKSYLTY FTDALWINNQ PLIAILGICS ALAVTTTVTT ALTMGFAVSF VTGCSSFVVS
LLRKITPESV RMIAQLIIIS LFVILIDQFL KAFFFTISKT LSVFVGLIIT NCIVMGRAES
MARHVSPIPA FLDGLGSGLG YGWVLVCISI IRELFGFGTI LGFRVIPEIL YTSAAHPDGY
ENLGLMVLAP SAFFLLGIMI WIVNIIRAPK TKR
