NQRD_HAEDU
ID NQRD_HAEDU Reviewed; 207 AA.
AC Q7VNU6;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE Short=Na(+)-NQR subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE Short=Na(+)-translocating NQR subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00428};
DE AltName: Full=NQR complex subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
DE AltName: Full=NQR-1 subunit D {ECO:0000255|HAMAP-Rule:MF_00428};
GN Name=nqrD {ECO:0000255|HAMAP-Rule:MF_00428}; OrderedLocusNames=HD_0382;
OS Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=233412;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=35000HP / ATCC 700724;
RA Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA Nguyen D., Wang J., Forst C., Hood L.;
RT "The complete genome sequence of Haemophilus ducreyi.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00428}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00428};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00428}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00428}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00428}.
CC -!- SIMILARITY: Belongs to the NqrDE/RnfAE family. {ECO:0000255|HAMAP-
CC Rule:MF_00428}.
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DR EMBL; AE017143; AAP95352.1; -; Genomic_DNA.
DR RefSeq; WP_010944405.1; NC_002940.2.
DR AlphaFoldDB; Q7VNU6; -.
DR SMR; Q7VNU6; -.
DR STRING; 233412.HD_0382; -.
DR EnsemblBacteria; AAP95352; AAP95352; HD_0382.
DR GeneID; 60733722; -.
DR KEGG; hdu:HD_0382; -.
DR eggNOG; COG1347; Bacteria.
DR HOGENOM; CLU_046659_1_1_6; -.
DR OMA; CIIMGRF; -.
DR Proteomes; UP000001022; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00428; NqrD; 1.
DR InterPro; IPR011292; NqrD.
DR InterPro; IPR003667; NqrDE/RnfAE.
DR PANTHER; PTHR30586:SF1; PTHR30586:SF1; 1.
DR Pfam; PF02508; Rnf-Nqr; 1.
DR PIRSF; PIRSF006102; NQR_DE; 1.
DR TIGRFAMs; TIGR01939; nqrD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane; NAD;
KW Reference proteome; Sodium; Sodium transport; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..207
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT D"
FT /id="PRO_0000214233"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00428"
SQ SEQUENCE 207 AA; 22494 MW; 299D37F51FD02624 CRC64;
MANNNLKKLL LSPISDNNPI ALQILGICSA LAVTTQLQTA FVMAIAVSLV TAFSSMFISM
IRNYIPNSIR IIVQMAIIAS LVILVDQILR AYVYDLSKQL SVFVGLIITN CIVMGRAEAF
AMKSAPLESF VDGIGNGLGY GAMLVIVAFL RELIGSGKIF GVTVLQTIQD GGWYQANGLF
LLAPSAFFII GFVIWAIRTW KPEQVEK
