ID   AROG_SOLLC              Reviewed;         541 AA.
AC   P37216;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic;
DE            EC=2.5.1.54;
DE   AltName: Full=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 2;
DE   AltName: Full=DAHP synthase 2;
DE   AltName: Full=Phospho-2-keto-3-deoxyheptonate aldolase 2;
DE   Flags: Precursor;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. UC82B;
RX   PubMed=7902741; DOI=10.1007/bf00021525;
RA   Goerlach J., Beck A., Henstrand J.M., Handa A.K., Herrmann K.M., Schmid J.,
RA   Amrhein N.;
RT   "Differential expression of tomato (Lycopersicon esculentum L.) genes
RT   encoding shikimate pathway isoenzymes. I. 3-deoxy-D-arabino-heptulosonate
RT   7-phosphate synthase.";
RL   Plant Mol. Biol. 23:697-706(1993).
CC   -!- FUNCTION: Involved in maintaining the supply of chorismate for the
CC       biosynthesis of the aromatic amino acids and other chorismate-derived
CC       metabolites.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
CC   -!- TISSUE SPECIFICITY: Highest levels seen in the roots and lower levels
CC       seen in the stems and flowers. Is undetectable in the leaves and
CC       cotyledons.
CC   -!- SIMILARITY: Belongs to the class-II DAHP synthase family.
CC       {ECO:0000305}.
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DR   EMBL; Z21793; CAA79856.1; -; mRNA.
DR   PIR; S40412; S40412.
DR   RefSeq; NP_001234418.1; NM_001247489.1.
DR   AlphaFoldDB; P37216; -.
DR   SMR; P37216; -.
DR   STRING; 4081.Solyc04g074480.2.1; -.
DR   PaxDb; P37216; -.
DR   PRIDE; P37216; -.
DR   GeneID; 544153; -.
DR   KEGG; sly:544153; -.
DR   eggNOG; ENOG502QPP7; Eukaryota.
DR   OrthoDB; 546472at2759; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000004994; Unplaced.
DR   ExpressionAtlas; P37216; baseline and differential.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002480; DAHP_synth_2.
DR   PANTHER; PTHR21337; PTHR21337; 1.
DR   Pfam; PF01474; DAHP_synth_2; 1.
DR   TIGRFAMs; TIGR01358; DAHP_synth_II; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Chloroplast;
KW   Plastid; Reference proteome; Transferase; Transit peptide.
FT   TRANSIT         1..74
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           75..541
FT                   /note="Phospho-2-dehydro-3-deoxyheptonate aldolase 2,
FT                   chloroplastic"
FT                   /id="PRO_0000002301"
FT   REGION          54..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   541 AA;  59937 MW;  233EBB9F2108FD85 CRC64;
     MALSTNTTTN SLLSNKSLLQ NQPLLSSPSK NAFFSNKSTK TVRFVQPIAA VHSSDSNKNP
     IVSDKPTKSS PPAATATTAP APAVTKTEWA VDSWKSKKAL QLPEYPDQEE LRSVLKTIDE
     FPPIVFAGEA RSLEERLGEA AMGRAFLLQG GDCAESFKEF NANNIRDTFR ILLQMGAVLM
     FGGQMPVIKV GRMAGQFAKP RSDSFEEKDG VKLPSYRGDN VNGDAFDVKS RTPDPQRLIR
     AYCQSAATLN LLRAFATGGY AAMQRINQWN LDFTEHSEQG DRYRELASRV DEALGFMTAA
     GLTMDHPIMK TTEFWTSHEC LLLPYEQSLT RRDSTSGLHY DCSAHFLWVG ERTRQLDGAH
     VEFLRGIANP LGIKVSDKMD PSALVKLIEI LNPQNKAGRI TIITRMGAEN MRVKLPHLIR
     AVRRAGQIVT WVSDPMHGNT IKAPCGLKTR PFDSIRAEVR AFFDVHDQEG SHPGGVHLEM
     TGQNVTECIG GSRTVTFDDL SSRYHTHCDP RLNASQSLEL SFIIAERLRK RRLGSQSTLG
     Q