ID   NQR_SOLTU               Reviewed;         194 AA.
AC   Q8H9D2;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=NAD(P)H:quinone oxidoreductase;
DE            Short=NAD(P)H:QR;
DE            EC=1.6.5.2;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RX   DOI=10.1007/s10327-003-0075-6;
RA   Nakane E., Kawakita K., Doke N., Yoshioka H.;
RT   "Elicitation of primary and secondary metabolism during defense in the
RT   potato.";
RL   J. Gen. Plant Pathol. 69:378-384(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44;
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
CC   -!- FUNCTION: The enzyme apparently serves as a quinone reductase in
CC       connection with conjugation reactions of hydroquinones involved in
CC       detoxification pathways. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + H(+) + NADH = a quinol + NAD(+);
CC         Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.2;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + H(+) + NADPH = a quinol + NADP(+);
CC         Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.2;
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- INDUCTION: By P.infestans. {ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the SsuE family. {ECO:0000305}.
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DR   EMBL; AB061251; BAC23037.1; -; mRNA.
DR   RefSeq; NP_001275452.1; NM_001288523.1.
DR   AlphaFoldDB; Q8H9D2; -.
DR   SMR; Q8H9D2; -.
DR   STRING; 4113.PGSC0003DMT400013821; -.
DR   EnsemblPlants; PGSC0003DMT400013821; PGSC0003DMT400013821; PGSC0003DMG400005404.
DR   GeneID; 102582514; -.
DR   Gramene; PGSC0003DMT400013821; PGSC0003DMT400013821; PGSC0003DMG400005404.
DR   KEGG; sot:102582514; -.
DR   eggNOG; KOG4530; Eukaryota.
DR   HOGENOM; CLU_055322_4_2_1; -.
DR   InParanoid; Q8H9D2; -.
DR   OMA; YGGVWAQ; -.
DR   OrthoDB; 1223874at2759; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; Q8H9D2; baseline.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0010181; F:FMN binding; IBA:GO_Central.
DR   GO; GO:0050136; F:NADH dehydrogenase (quinone) activity; IEA:RHEA.
DR   GO; GO:0008753; F:NADPH dehydrogenase (quinone) activity; IEA:RHEA.
DR   Gene3D; 3.40.50.360; -; 1.
DR   InterPro; IPR029039; Flavoprotein-like_sf.
DR   InterPro; IPR005025; FMN_Rdtase-like.
DR   Pfam; PF03358; FMN_red; 1.
DR   SUPFAM; SSF52218; SSF52218; 1.
PE   2: Evidence at transcript level;
KW   Flavoprotein; FMN; NAD; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..194
FT                   /note="NAD(P)H:quinone oxidoreductase"
FT                   /id="PRO_0000160602"
SQ   SEQUENCE   194 AA;  21316 MW;  F5E003D1AEEAB40E CRC64;
     MAAQPVIKVA GLCGSLRKGS YNRGLLNAAM EICKDSITGM EIEYVDISPL PFLNTDLEVN
     GTYPPVVEAF RKKIEEADCF LFASPEYNYS ITGPLKNAID WASRPPNVWA DKAAAMVSAG
     GGFGGGRSQY HLRQIGVFLD LHFINKPEFF LNAFQQPPKF DSDGVLTDEE TKQRLRAVLL
     ALQALALKLK GKCE