NR0B1_MACMU
ID NR0B1_MACMU Reviewed; 470 AA.
AC Q9BG93;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Nuclear receptor subfamily 0 group B member 1;
DE AltName: Full=Nuclear receptor DAX-1;
GN Name=NR0B1; Synonyms=DAX1;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11112659; DOI=10.1086/316932;
RA Patel M., Dorman K.S., Zhang Y.-H., Huang B.-L., Arnold A.P.,
RA Sinsheimer J.S., Vilain E., McCabe E.R.B.;
RT "Primate DAX1, SRY, and SOX9: evolutionary stratification of sex-
RT determination pathway.";
RL Am. J. Hum. Genet. 68:275-280(2001).
CC -!- FUNCTION: Orphan nuclear receptor. Component of a cascade required for
CC the development of the hypothalamic-pituitary-adrenal-gonadal axis.
CC Acts as a coregulatory protein that inhibits the transcriptional
CC activity of other nuclear receptors through heterodimeric interactions.
CC May also have a role in the development of the embryo and in the
CC maintenance of embryonic stem cell pluripotency (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2
CC (By similarity). Interacts with ESRRB; represses ESRRB activity at the
CC GATA6 promoter (By similarity). {ECO:0000250,
CC ECO:0000250|UniProtKB:Q61066}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in
CC the cytoplasm and in the nucleus (By similarity). {ECO:0000250}.
CC -!- DOMAIN: Homodimerization involved an interaction between amino and
CC carboxy termini involving LXXLL motifs and steroid binding domain (AF-2
CC motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal
CC LXXLL motifs (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR0
CC subfamily. {ECO:0000305}.
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DR EMBL; AF322896; AAK01647.1; -; mRNA.
DR AlphaFoldDB; Q9BG93; -.
DR SMR; Q9BG93; -.
DR STRING; 9544.ENSMMUP00000016782; -.
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; Q9BG93; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
DR GO; GO:0032448; F:DNA hairpin binding; ISS:UniProtKB.
DR GO; GO:0016922; F:nuclear receptor binding; ISS:UniProtKB.
DR GO; GO:0019904; F:protein domain specific binding; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0030325; P:adrenal gland development; ISS:UniProtKB.
DR GO; GO:0008406; P:gonad development; ISS:UniProtKB.
DR GO; GO:0008584; P:male gonad development; ISS:UniProtKB.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0010894; P:negative regulation of steroid biosynthetic process; ISS:HGNC-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR033544; NR0B1/2.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR025900; Nuclear_receptor_repeat.
DR PANTHER; PTHR24081; PTHR24081; 3.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF14046; NR_Repeat; 4.
DR PRINTS; PR00398; STRDHORMONER.
DR SMART; SM00430; HOLI; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Receptor; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..470
FT /note="Nuclear receptor subfamily 0 group B member 1"
FT /id="PRO_0000280116"
FT REPEAT 1..67
FT /note="1"
FT REPEAT 68..133
FT /note="2"
FT REPEAT 134..200
FT /note="3"
FT REPEAT 201..253
FT /note="4; truncated"
FT DOMAIN 205..469
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT REGION 1..253
FT /note="4 X 67 AA tandem repeats"
FT MOTIF 13..17
FT /note="LXXLL motif 1"
FT MOTIF 80..84
FT /note="LXXLL motif 2"
FT MOTIF 146..150
FT /note="LXXLL motif 3"
FT MOTIF 461..466
FT /note="AF-2 motif"
SQ SEQUENCE 470 AA; 51879 MW; 8FC9C4768D6721EB CRC64;
MAGENHQWQG SILYNMLMSA KQTRAAPEAP ETRLVDQCWG CSCGDEPGVG REGLLGGRNV
SLLYRCCFCG KDHPRQGSIL YSMLTNAKQT YAAPKAPEAT LGPCWGCSCG SDPGVGRTGL
PGGRPVALLY RCCFCGEDHP RQGSILYSLL TSAKQTHVAP AAPEARPGGA WWDRSYFAQR
PGGREALPGG RAMGLLYRCC FCGEDHPQQG STLYCMPTST NQAQAAPEER PRAPWWDTSS
GALRPVALKN PQVVCEAASA GLLKTLRFVK YLPCFQVLPL DQQLVLVRNC WASLLMLELA
QDRLQFETVE VSEPSMLQKI LTTRRRETGG DEPLPVPTLQ HHLAPPAEAR KVPSASQVQA
IKCFLSKCWS LNISTKEYAY LKGTVLFNPD VPGLQCVKYI QGLQWGTQQI LSEHTRMTHQ
GPHDRFIELN STLFLLRFIN ANVIAELFFR PIIGTVSMDD MMLEMLCTKL
