ID   NR0B1_PONPY             Reviewed;         470 AA.
AC   Q9BG96;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Nuclear receptor subfamily 0 group B member 1;
DE   AltName: Full=Nuclear receptor DAX-1;
GN   Name=NR0B1; Synonyms=DAX1;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11112659; DOI=10.1086/316932;
RA   Patel M., Dorman K.S., Zhang Y.-H., Huang B.-L., Arnold A.P.,
RA   Sinsheimer J.S., Vilain E., McCabe E.R.B.;
RT   "Primate DAX1, SRY, and SOX9: evolutionary stratification of sex-
RT   determination pathway.";
RL   Am. J. Hum. Genet. 68:275-280(2001).
CC   -!- FUNCTION: Orphan nuclear receptor. Component of a cascade required for
CC       the development of the hypothalamic-pituitary-adrenal-gonadal axis.
CC       Acts as a coregulatory protein that inhibits the transcriptional
CC       activity of other nuclear receptors through heterodimeric interactions.
CC       May also have a role in the development of the embryo and in the
CC       maintenance of embryonic stem cell pluripotency (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2
CC       (By similarity). Interacts with ESRRB; represses ESRRB activity at the
CC       GATA6 promoter (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:Q61066}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in
CC       the cytoplasm and in the nucleus (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: Homodimerization involved an interaction between amino and
CC       carboxy termini involving LXXLL motifs and steroid binding domain (AF-2
CC       motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal
CC       LXXLL motifs (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR0
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF322893; AAK01644.1; -; mRNA.
DR   AlphaFoldDB; Q9BG96; -.
DR   SMR; Q9BG96; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
DR   GO; GO:0032448; F:DNA hairpin binding; ISS:UniProtKB.
DR   GO; GO:0016922; F:nuclear receptor binding; ISS:UniProtKB.
DR   GO; GO:0019904; F:protein domain specific binding; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0030325; P:adrenal gland development; ISS:UniProtKB.
DR   GO; GO:0008406; P:gonad development; ISS:UniProtKB.
DR   GO; GO:0008584; P:male gonad development; ISS:UniProtKB.
DR   GO; GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0010894; P:negative regulation of steroid biosynthetic process; ISS:HGNC-UCL.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   Gene3D; 1.10.565.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR033544; NR0B1/2.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR025900; Nuclear_receptor_repeat.
DR   PANTHER; PTHR24081; PTHR24081; 3.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF14046; NR_Repeat; 4.
DR   PRINTS; PR00398; STRDHORMONER.
DR   SMART; SM00430; HOLI; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Receptor; Repeat; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..470
FT                   /note="Nuclear receptor subfamily 0 group B member 1"
FT                   /id="PRO_0000280118"
FT   REPEAT          1..67
FT                   /note="1"
FT   REPEAT          68..133
FT                   /note="2"
FT   REPEAT          134..200
FT                   /note="3"
FT   REPEAT          201..253
FT                   /note="4; truncated"
FT   DOMAIN          215..469
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   REGION          1..253
FT                   /note="4 X 67 AA tandem repeats"
FT   MOTIF           13..17
FT                   /note="LXXLL motif 1"
FT   MOTIF           80..84
FT                   /note="LXXLL motif 2"
FT   MOTIF           146..150
FT                   /note="LXXLL motif 3"
FT   MOTIF           461..466
FT                   /note="AF-2 motif"
SQ   SEQUENCE   470 AA;  51780 MW;  1657992D6FAAD9A0 CRC64;
     MAGENHQWQG SILYNMLMSA KQTRAAPEAP ETRLVDQCWG CSCGDEPGVG REGLLGGRNV
     ALLYRCCFCG KDHPRQGSIL YSMLTSAKQT YATPKAPEAT LGPCWGCSCG SDPGVGRTGL
     PGGRPVALLY RCCFCGEDHP RQGSILYSLL TSAKQTHVAP AAPEARPGGA WWDRSYFAQK
     PGGREALPGG RATALLYRCC FCGEDHPQQG STLYCMPTST NQAQAAPEER PRAPWWDASS
     GALRPVALKN PQVVCEAASA GLLKTLRFVK YLPCFQVLPL DQQLVLVRNC WASLLMLELA
     QDRLQFETVE VSEPSMLQKI LTTRRRETGG NEPLPVPTLQ PHLAPPAEAR KVPSASQVQA
     IKCFLSKCWS LNISTKEYAY LKGTVLFNRD VPGLQCVKYI QGLQWGTQQI LSEHTRMTHQ
     GPHDRFIELN SALFLLRFIN ANVIAELFFR PIIGTVSMDD MMLEMLCTKI