NR13_CHICK
ID NR13_CHICK Reviewed; 177 AA.
AC Q90ZN1;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Anti-apoptotic protein NR13;
DE AltName: Full=Apoptosis regulator Nr-13;
GN Name=NR13;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12133006; DOI=10.1042/bj20020836;
RA Lalle P., Aouacheria A., Dumont-Miscopein A., Jambon M., Venet S.,
RA Bobichon H., Colas P., Deleage G., Geourjon C., Gillet G.;
RT "Evidence for crucial electrostatic interactions between Bcl-2 homology
RT domains BH3 and BH4 in the anti-apoptotic Nr-13 protein.";
RL Biochem. J. 368:213-221(2002).
RN [2]
RP FUNCTION, AND INTERACTION WITH BAX.
RX PubMed=10090728; DOI=10.1101/gad.13.6.718;
RA Lee R.M., Gillet G., Burnside J., Thomas S.J., Neiman P.;
RT "Role of Nr13 in regulation of programmed cell death in the bursa of
RT Fabricius.";
RL Genes Dev. 13:718-728(1999).
CC -!- FUNCTION: Shows anti-apoptotic properties. Counteract the pro-apoptotic
CC activity of BAX. {ECO:0000269|PubMed:10090728}.
CC -!- SUBUNIT: Interacts with BAX. {ECO:0000269|PubMed:10090728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed preferentially in heart, skeletal muscle,
CC retina, optical tectum and bursa of Fabricius.
CC -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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DR EMBL; AF375661; AAK54806.1; -; mRNA.
DR RefSeq; NP_989853.1; NM_204522.1.
DR AlphaFoldDB; Q90ZN1; -.
DR SMR; Q90ZN1; -.
DR Ensembl; ENSGALT00000082198; ENSGALP00000053183; ENSGALG00000030871.
DR GeneID; 395193; -.
DR KEGG; gga:395193; -.
DR CTD; 10017; -.
DR VEuPathDB; HostDB:geneid_395193; -.
DR GeneTree; ENSGT01050000244872; -.
DR InParanoid; Q90ZN1; -.
DR OMA; GRKMSCG; -.
DR OrthoDB; 1557685at2759; -.
DR PhylomeDB; Q90ZN1; -.
DR PRO; PR:Q90ZN1; -.
DR Proteomes; UP000000539; Chromosome 10.
DR Bgee; ENSGALG00000030871; Expressed in lung and 14 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0089720; F:caspase binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IBA:GO_Central.
DR GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IBA:GO_Central.
DR Gene3D; 1.10.437.10; -; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR PANTHER; PTHR11256; PTHR11256; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR PRINTS; PR01862; BCL2FAMILY.
DR SMART; SM00337; BCL; 1.
DR SUPFAM; SSF56854; SSF56854; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
DR PROSITE; PS01258; BH2; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..177
FT /note="Anti-apoptotic protein NR13"
FT /id="PRO_0000143070"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 75..94
FT /note="BH1"
FT /evidence="ECO:0000250"
FT MOTIF 126..141
FT /note="BH2"
FT /evidence="ECO:0000250"
SQ SEQUENCE 177 AA; 18778 MW; F06EF9C8E1AF250D CRC64;
MPGSLKEETA LLLEDYFQHR AGGAALPPSA TAAELRRAAA ELERRERPFF RSCAPLARAE
PREAAALLRK VAAQLEAEGG LNWGRLLALV VFTGTLAAAL AESGCEEGPS RLAAALAAYL
AEEQGEWLEE HGGWDGFCRF FGRHGSQPAD QNSTLSNAIM AAAGFGIAGL AFLLVVR
