NR1AA_DANRE
ID NR1AA_DANRE Reviewed; 1491 AA.
AC A1XQX0;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Neurexin-1a;
DE AltName: Full=Neurexin Ia-alpha;
DE AltName: Full=Neurexin-1a-alpha;
DE Flags: Precursor;
GN Name=nrxn1a;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND ALTERNATIVE SPLICING.
RX PubMed=17041151; DOI=10.1093/molbev/msl147;
RA Rissone A., Monopoli M., Beltrame M., Bussolino F., Cotelli F., Arese M.;
RT "Comparative genome analysis of the neurexin gene family in Danio rerio:
RT insights into their functions and evolution.";
RL Mol. Biol. Evol. 24:236-252(2007).
CC -!- FUNCTION: Neuronal cell surface protein that may be involved in cell
CC recognition and cell adhesion.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=2;
CC Comment=A number of isoforms, alpha-type and beta-type are produced
CC by alternative promoter usage. Beta-type isoforms differ from
CC alpha-type isoforms in their N-terminus.;
CC Name=Alpha;
CC IsoId=A1XQX0-1; Sequence=Displayed;
CC Name=Beta;
CC IsoId=A1XQX1-1; Sequence=External;
CC -!- DEVELOPMENTAL STAGE: After the very early developmental stages, the
CC expression levels decrease and remain relatively constant until around
CC 24 h, with the onset of an increase of expression that continues till
CC the larval stages. {ECO:0000269|PubMed:17041151}.
CC -!- SIMILARITY: Belongs to the neurexin family. {ECO:0000305}.
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DR EMBL; DQ641424; ABG25161.1; -; mRNA.
DR RefSeq; NP_001073490.1; NM_001080021.2. [A1XQX0-1]
DR AlphaFoldDB; A1XQX0; -.
DR SMR; A1XQX0; -.
DR STRING; 7955.ENSDARP00000087526; -.
DR PaxDb; A1XQX0; -.
DR Ensembl; ENSDART00000111239; ENSDARP00000102322; ENSDARG00000061647. [A1XQX0-1]
DR GeneID; 565531; -.
DR KEGG; dre:565531; -.
DR CTD; 565531; -.
DR ZFIN; ZDB-GENE-070206-1; nrxn1a.
DR eggNOG; KOG3514; Eukaryota.
DR GeneTree; ENSGT00940000163749; -.
DR InParanoid; A1XQX0; -.
DR OrthoDB; 35129at2759; -.
DR PhylomeDB; A1XQX0; -.
DR TreeFam; TF321302; -.
DR Reactome; R-DRE-6794361; Neurexins and neuroligins.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 12.
DR Bgee; ENSDARG00000061647; Expressed in brain and 7 other tissues.
DR ExpressionAtlas; A1XQX0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0002040; P:sprouting angiogenesis; IMP:ZFIN.
DR CDD; cd00110; LamG; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR InterPro; IPR027789; Syndecan/Neurexin_dom.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR Pfam; PF01034; Syndecan; 1.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; SSF49899; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 2: Evidence at transcript level;
KW Alternative promoter usage; Alternative splicing; Calcium; Cell adhesion;
KW Disulfide bond; EGF-like domain; Membrane; Metal-binding;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..1491
FT /note="Neurexin-1a"
FT /id="PRO_0000412537"
FT TOPO_DOM 28..1415
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1416..1436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1437..1491
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 28..208
FT /note="Laminin G-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 198..236
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 263..460
FT /note="Laminin G-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 467..661
FT /note="Laminin G-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 665..702
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 707..880
FT /note="Laminin G-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 894..1069
FT /note="Laminin G-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 1072..1109
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1113..1314
FT /note="Laminin G-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT REGION 1318..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1473..1491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 309
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 326
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 394
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT DISULFID 202..214
FT /evidence="ECO:0000250"
FT DISULFID 208..223
FT /evidence="ECO:0000250"
FT DISULFID 225..235
FT /evidence="ECO:0000250"
FT DISULFID 424..460
FT /evidence="ECO:0000250"
FT DISULFID 632..661
FT /evidence="ECO:0000250"
FT DISULFID 669..680
FT /evidence="ECO:0000250"
FT DISULFID 674..689
FT /evidence="ECO:0000250"
FT DISULFID 691..701
FT /evidence="ECO:0000250"
FT DISULFID 1041..1069
FT /evidence="ECO:0000250"
FT DISULFID 1076..1087
FT /evidence="ECO:0000250"
FT DISULFID 1081..1096
FT /evidence="ECO:0000250"
FT DISULFID 1098..1108
FT /evidence="ECO:0000250"
SQ SEQUENCE 1491 AA; 164313 MW; BC00B3E400CE8473 CRC64;
MSFSMRNGAH LIWIGLLVCC LVDMGASMEF TGAEGQWARF PMWNACCESE MSFNMKTKSA
HGLLVYFDDE GFCDFLELLI HNGRLSLRFS IFCAEPATVF SDTAVNDSRW HAVTLRRNFK
NTTLVVDEEI KWVEVKSKRR DMTVFSHLFL GGIPPELRSV ALRLTSSAIK DEVPYKGWIT
NLRVNGSEPV LIGSDGVNSD ICEADHICLN GGVCSIVNDE PICDCSETGF QGKDCSEEEA
YVGGLAHLMM GDQGKRKERE EYMATFKGSE YFCYDLSPNP IQSSSDEITL SFKTLQRNGL
MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG KFNDNAWHDV KVTRNLRQHS
GIGHAMVNKL HCSVTISVDG ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN
FMGCLKEVVY KNNDVRLELS RLAKLGDPKM KVSGVVAFKC ENVATLDPVT FETPESFITL
DKWSAKKAGS ISFDFRTTEP NGLLLFSHGK PKPQQQKDPK SPKTLKVDFF AIEMLDGHLY
LLLDMGSGTT KTRAVNKKVN DGEWYHVDFQ RDGRSGTISV NSIRTPYNAP GESEILDLDD
KLYLGGLPED RAGLIFPTEV WTALLNYGYV GCVRDLFMDG QSKDIRRIAE AQRAVGVKPS
CSKEPPKQCL SNPCLNSGTC REGWNRYVCD CSGTGYLGRS CERDATILSY DGSKFMKIQL
PVVMHTEAED VSLRFRSQRA YGVLMATTSQ NSADTLRLEL DGGRVRLTVN LDCIRINCTT
SKGPETIFSG QNLNDNEWHT VRVVRRGKSL KLMVDDLQPS EGQITGDHTQ LEFHNVETGI
VTEKRYMPAV PSNFIGHLQG LSFNGMSYID LCKNGDIDYC ELNAMIGYRS IVADPVTFKS
RSSYVTLPTL QAYYSMHLFF QFKTTSPDGL ILYNRGDGND FIVVELVKGY LHYVSDLGNG
AHLIKGNSNT PLNDNHWHNV MISRDTNNLH TVKIDTKITT QTTMGAKNLD LKGDLYVGGV
AKDMYKDLPK LVHSKEGFQG CLASVDLNGR LPDLQSDALS TAGQVERGCE GPSTTCQEDS
CSNQGVCLQQ WEGFSCDCSM TSYGGPLCND PGTTYIFGRD GGLIVYTWPP NDRPSTRADR
LAVGFSTQQK DAVLVRVDSS SGLGDYLQLQ IERGNIKVVF NVGTDDINIE ETSKFVNDGK
YHIVRFTRSG GNATLQVDDL PVIERYPSGN IDNERLAIAR QRIPYRLGRV VDDWLLDKGR
QLTIFNSQTT IKIGGWEKGS RPFQGQLSGL YYNGLKVLNM AAEGDPNVRV EGSARLVGDM
PSSSITPQSS VSAAGNRSET SPSITDITTT TASNRQGKQT TTPQDDLLVA SAECPSDDED
IDPCDPSSGG LAHPPLPEAK GYPSPEVIRE SSSTTGMVVG IVAAAALCIL ILLYAMYKYR
NRDEGSYHVD ESRNYISNSA TQPNGAAVKE KPIGVPKNKK DKKNKDKEYY V
