ID   NR1BB_DANRE             Reviewed;         448 AA.
AC   A1XQX3;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Neurexin-1b-beta;
DE   AltName: Full=Neurexin Ib-beta;
DE   Flags: Precursor;
GN   Name=nrxn1b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND ALTERNATIVE SPLICING.
RX   PubMed=17041151; DOI=10.1093/molbev/msl147;
RA   Rissone A., Monopoli M., Beltrame M., Bussolino F., Cotelli F., Arese M.;
RT   "Comparative genome analysis of the neurexin gene family in Danio rerio:
RT   insights into their functions and evolution.";
RL   Mol. Biol. Evol. 24:236-252(2007).
CC   -!- FUNCTION: Neuronal cell surface protein that may be involved in cell
CC       recognition and cell adhesion. May play a role in formation or
CC       maintenance of synaptic junctions.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative promoter usage, Alternative splicing; Named isoforms=2;
CC         Comment=A number of isoforms, alpha-type and beta-type are produced
CC         by alternative promoter usage. Beta-type isoforms differ from
CC         alpha-type isoforms in their N-terminus.;
CC       Name=Beta;
CC         IsoId=A1XQX3-1; Sequence=Displayed;
CC       Name=Alpha;
CC         IsoId=A1XQX2-1; Sequence=External;
CC   -!- DEVELOPMENTAL STAGE: After the very early developmental stages, the
CC       expression levels decrease and remain relatively constant until around
CC       24 h, with the onset of an increase of expression that continues till
CC       the larval stages. {ECO:0000269|PubMed:17041151}.
CC   -!- SIMILARITY: Belongs to the neurexin family. {ECO:0000305}.
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DR   EMBL; DQ641427; ABG25164.1; -; mRNA.
DR   AlphaFoldDB; A1XQX3; -.
DR   SMR; A1XQX3; -.
DR   ZFIN; ZDB-GENE-070206-3; nrxn1b.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd00110; LamG; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR003585; Neurexin-like.
DR   InterPro; IPR027789; Syndecan/Neurexin_dom.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF01034; Syndecan; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   SMART; SM00282; LamG; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative promoter usage; Alternative splicing; Cell adhesion; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..448
FT                   /note="Neurexin-1b-beta"
FT                   /id="PRO_0000412540"
FT   TOPO_DOM        39..375
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        397..448
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          71..269
FT                   /note="Laminin G-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   REGION          426..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   448 AA;  49054 MW;  E64E985EE9DBF533 CRC64;
     MFGGWRLVVW QIFSEIITRR LGFWICLYFA ALSVGMISGS EPLVRTRHIQ NTHTVPINRS
     PGSLRAWQAG STYVFGRQGG VITYSWPPHD RPSTRVDRLA LGFSTLMEDA TLVRVDSSAG
     LGDYLKLHIV KGNVVAVFNV GTYDINIEEK AKLVNDGNYH IVRFTRSGGN ATLQVDDLPV
     IERFPPGHID SHRLGTGRLP YRRLVEESLP KNGRQLTIFN SQMTIRIGGW QKQQVSGFQG
     QMSGFYYNGL KVFSMAADGD PNVRMEGSVR LVGELQSSST PHGGATVYQS SVTEISSTTS
     NTITITYSTP ADEQQTTDEL LVASAECPSD DEDIDPCEPS SGTLCCFVPP AGPTGPAISS
     FPGPAEVFRE SNGTTGMVVG IVAGAALCIL ILLYAMYKYR NRDEGSYHVD ESRNYICNSN
     GAALKEKNTA DDDSGSKSKK NKNKEYYV