ID   NR1I3_MACMU             Reviewed;         352 AA.
AC   Q8MIM3;
DT   21-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2004, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Nuclear receptor subfamily 1 group I member 3;
DE   AltName: Full=Constitutive androstane receptor;
DE            Short=CAR;
GN   Name=NR1I3; Synonyms=CAR;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yueh M.-F., Raucy J.;
RT   "Monkey CAR regulates drug-metabolizing enzymes.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds and transactivates the retinoic acid response elements
CC       that control expression of the retinoic acid receptor beta 2 and
CC       alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital
CC       responsive element module of the human CYP2B6 gene and the CYP3A4
CC       xenobiotic response element (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts
CC       with ECT2. Directly interacts with DNAJC7; this complex may also
CC       include HSP90 (By similarity). Interacts with CRY1 (By similarity).
CC       Interacts with CRY2 in a ligand-dependent manner (By similarity).
CC       {ECO:0000250|UniProtKB:O35627}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC       Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
CC       Note=Recruited to the cytoplasm by DNAJC7. {ECO:0000250}.
CC   -!- DOMAIN: Composed by a short N-terminal domain followed by the DNA
CC       binding, hinge, and ligand binding/dimerization domains.
CC   -!- PTM: Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is
CC       required for nuclear translocation and activation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM76230.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY116212; AAM76230.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001028068.1; NM_001032896.1.
DR   AlphaFoldDB; Q8MIM3; -.
DR   SMR; Q8MIM3; -.
DR   STRING; 9544.ENSMMUP00000023825; -.
DR   GeneID; 574249; -.
DR   KEGG; mcc:574249; -.
DR   CTD; 9970; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_007368_12_0_1; -.
DR   InParanoid; Q8MIM3; -.
DR   OrthoDB; 297114at2759; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001728; ThyrH_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00546; THYROIDHORMR.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Cytoskeleton; DNA-binding; Metal-binding; Nucleus;
KW   Phosphoprotein; Receptor; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..352
FT                   /note="Nuclear receptor subfamily 1 group I member 3"
FT                   /id="PRO_0000053553"
FT   DOMAIN          109..352
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        8..83
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         11..31
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         47..71
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   MOD_RES         38
FT                   /note="Phosphothreonine; by PKC"
FT                   /evidence="ECO:0000250|UniProtKB:Q14994"
SQ   SEQUENCE   352 AA;  39923 MW;  DC005B3D52962FD4 CRC64;
     MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA GSCEVSKIQR
     RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ QTPMQLSNEQ EELIQTLLGA
     HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT LAPVLPLVTH FADVNTFMVQ QVIKFTKDLP
     VFRSLPIEDQ ISLLKGAAVE ICHIVLNTTF CLQTQNFLCG PLRYTIEDAA RVSPAVGFQV
     EFLELLFHFH GTLRKLQLQE PEYVLLAAMA LFSPDRPGVT QRHEIDQLQE EMALTLQSYI
     KGQQQRPRDR FLYAKLLGLL AELRSINEAY GYQIQHIQGL SAMMPLLQEI CS