ID   NR2C1_XENTR             Reviewed;         636 AA.
AC   Q28CK1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Nuclear receptor subfamily 2 group C member 1;
DE   AltName: Full=Developmental orphan receptor 2;
DE            Short=DOR2;
DE   AltName: Full=Orphan nuclear receptor TR2;
DE   AltName: Full=Testicular receptor 2;
GN   Name=nr2c1 {ECO:0000312|EMBL:CAJ83740.1};
GN   Synonyms=dor2 {ECO:0000250|UniProtKB:Q6GN21}; ORFNames=TEgg078f23.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ83740.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg {ECO:0000312|EMBL:CAJ83740.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ83740.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6 {ECO:0000312|EMBL:AAI23035.1};
RC   TISSUE=Oviduct {ECO:0000312|EMBL:AAI23035.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Orphan nuclear receptor. Binds the IR7 element in the
CC       promoter of its own gene in an autoregulatory negative feedback
CC       mechanism. Primarily repressor of a broad range of genes. Binds to
CC       hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half
CC       site direct repeat consensus sequences (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily. {ECO:0000255}.
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DR   EMBL; CR926338; CAJ83740.1; -; mRNA.
DR   EMBL; BC123034; AAI23035.1; -; mRNA.
DR   RefSeq; NP_001016207.1; NM_001016207.2.
DR   RefSeq; XP_012814450.1; XM_012958996.2.
DR   RefSeq; XP_012814451.1; XM_012958997.2.
DR   AlphaFoldDB; Q28CK1; -.
DR   STRING; 8364.ENSXETP00000013305; -.
DR   PaxDb; Q28CK1; -.
DR   DNASU; 548961; -.
DR   GeneID; 548961; -.
DR   KEGG; xtr:548961; -.
DR   CTD; 7181; -.
DR   Xenbase; XB-GENE-484727; nr2c1.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_007368_16_2_1; -.
DR   InParanoid; Q28CK1; -.
DR   OrthoDB; 278171at2759; -.
DR   PhylomeDB; Q28CK1; -.
DR   Reactome; R-XTR-383280; Nuclear Receptor transcription pathway.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023840; Expressed in testis and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..636
FT                   /note="Nuclear receptor subfamily 2 group C member 1"
FT                   /id="PRO_0000287914"
FT   DOMAIN          382..623
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        149..224
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         152..172
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         188..207
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   636 AA;  70465 MW;  BB7EAB09854ED54A CRC64;
     MASIEEIAHQ IIEQQMGEIS RSQPEISQTA LMDGTTQRIQ LVPSESSVSV PQRIQIVTDP
     QTGQKIQIVT ALDQSGASKQ FILTNNDGSL PSKVILTRQD SSQGKVYLTT PDAAGVNQLF
     ISTPDVPAQH IQILSDTQCL DQNLNKQLVE LCVVCGDKAS GRHYGAVTCE GCKGFFKRSI
     RKNLVYTCRG SKDCVINKHY RNRCQYCRLQ RCIALGMKQD SVQCERKPIE VSREKSSNCA
     ASTEKIYIRK DLRSPLAATT TFVTENKTSR TTSLLDSGML VNIQQSGVKN ESILITPNKV
     DACQGDLSTL ANVVTSLANL NKSKELPQTN TELSIIESLS NGDSSLSELA QDDQSNSEVT
     RAFDTLAKAL NQSENSAQGS SECVGSNSNL TDANVEIEGP LLSDAHIAFR LTMPSPMPEY
     LNVHYICESA SRLLFLSMHW ARSIPSFQSL GQENSISLVK ACWNELFSLG LAQCCQVMNV
     ETILAAFVNH LHNSMQHDKL SADKVKLVMD HIFKLQEFCN SMVKLSVDGY EYAYLKAIAL
     FSPDHPGLEN VSHIEKLQEK AYMEFQDYVT KTYPEDTYRL SRLLLRLPAL RLLNAAITEE
     LFFAGLIGNV QIDSIIPYIL RMETSDYNSQ IIGLTV