ID   NR2CA_DANRE             Reviewed;         141 AA.
AC   Q1ED21; A3KQI6; Q4VBI9;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Nuclear receptor 2C2-associated protein;
DE   AltName: Full=TR4 orphan receptor-associated 16 kDa protein homolog;
GN   Name=nr2c2ap; Synonyms=tra16; ORFNames=ch211-125m10.4, zgc:136330;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a repressor of nr2c2-mediated transactivation by
CC       suppressing the binding between nr2c2 and its response element in
CC       target genes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NR2C2AP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAM56300.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX649643; CAM56300.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BC095749; AAH95749.1; -; mRNA.
DR   EMBL; BC117584; AAI17585.1; -; mRNA.
DR   RefSeq; NP_001038792.1; NM_001045327.2.
DR   AlphaFoldDB; Q1ED21; -.
DR   SMR; Q1ED21; -.
DR   STRING; 7955.ENSDARP00000115972; -.
DR   PaxDb; Q1ED21; -.
DR   GeneID; 724051; -.
DR   KEGG; dre:724051; -.
DR   CTD; 126382; -.
DR   ZFIN; ZDB-GENE-050208-758; nr2c2ap.
DR   eggNOG; ENOG502RZAY; Eukaryota.
DR   InParanoid; Q1ED21; -.
DR   OrthoDB; 1412628at2759; -.
DR   PhylomeDB; Q1ED21; -.
DR   PRO; PR:Q1ED21; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR012919; SUN_dom.
DR   Pfam; PF07738; Sad1_UNC; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..141
FT                   /note="Nuclear receptor 2C2-associated protein"
FT                   /id="PRO_0000295587"
FT   CONFLICT        102
FT                   /note="S -> I (in Ref. 1; CAM56300)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   141 AA;  16130 MW;  33C747FEE25FC5CB CRC64;
     MAESLICNST QSRVSSVLNR DVKQFGKKFM FDSNEETCWN SDQGESQWVL LEFPQHVKVS
     EVRLQFQGGF SGKSCKLEGS SKDENLRHIL NFYPEDNNSL QSFPIPDAPL VQKLKIVFEN
     STDFFGRIIV YTLDILGEKD L