NR2CA_HUMAN
ID NR2CA_HUMAN Reviewed; 139 AA.
AC Q86WQ0; A6NGP7; B4DW92;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Nuclear receptor 2C2-associated protein;
DE AltName: Full=TR4 orphan receptor-associated 16 kDa protein;
GN Name=NR2C2AP; Synonyms=TRA16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH NR2C2,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=12486131; DOI=10.1074/jbc.m207116200;
RA Yang Y., Wang X., Dong T., Kim E., Lin W.-J., Chang C.;
RT "Identification of a novel testicular orphan receptor-4 (TR4)-associated
RT protein as repressor for the selective suppression of TR4-mediated
RT transactivation.";
RL J. Biol. Chem. 278:7709-7717(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Synovium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May act as a repressor of NR2C2-mediated transactivation by
CC suppressing the binding between NR2C2/TR4 and the TR4-response element
CC in target genes. {ECO:0000269|PubMed:12486131}.
CC -!- SUBUNIT: Interacts with NR2C2/TR4. {ECO:0000269|PubMed:12486131}.
CC -!- INTERACTION:
CC Q86WQ0; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-10260040, EBI-742054;
CC Q86WQ0; P42858: HTT; NbExp=3; IntAct=EBI-10260040, EBI-466029;
CC Q86WQ0; P49116-2: NR2C2; NbExp=5; IntAct=EBI-10260040, EBI-20709881;
CC Q86WQ0; Q04864: REL; NbExp=3; IntAct=EBI-10260040, EBI-307352;
CC Q86WQ0; Q04864-2: REL; NbExp=3; IntAct=EBI-10260040, EBI-10829018;
CC Q86WQ0; O15427: SLC16A3; NbExp=3; IntAct=EBI-10260040, EBI-7600166;
CC Q86WQ0; P15884: TCF4; NbExp=3; IntAct=EBI-10260040, EBI-533224;
CC Q86WQ0; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-10260040, EBI-11139477;
CC Q86WQ0; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-10260040, EBI-2799833;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12486131}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86WQ0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86WQ0-2; Sequence=VSP_056072;
CC -!- TISSUE SPECIFICITY: Expressed in all tissues examined, with highest
CC expression in heart, skeletal muscle and pancreas.
CC {ECO:0000269|PubMed:12486131}.
CC -!- SIMILARITY: Belongs to the NR2C2AP family. {ECO:0000305}.
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DR EMBL; AY101377; AAM48286.1; -; mRNA.
DR EMBL; AK301426; BAG62954.1; -; mRNA.
DR EMBL; AC003110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057837; AAH57837.1; -; mRNA.
DR CCDS; CCDS32967.1; -. [Q86WQ0-1]
DR CCDS; CCDS74316.1; -. [Q86WQ0-2]
DR RefSeq; NP_001287874.1; NM_001300945.1. [Q86WQ0-2]
DR RefSeq; NP_795361.1; NM_176880.5. [Q86WQ0-1]
DR AlphaFoldDB; Q86WQ0; -.
DR SMR; Q86WQ0; -.
DR BioGRID; 125987; 9.
DR IntAct; Q86WQ0; 8.
DR STRING; 9606.ENSP00000402756; -.
DR iPTMnet; Q86WQ0; -.
DR PhosphoSitePlus; Q86WQ0; -.
DR BioMuta; NR2C2AP; -.
DR EPD; Q86WQ0; -.
DR jPOST; Q86WQ0; -.
DR MassIVE; Q86WQ0; -.
DR MaxQB; Q86WQ0; -.
DR PaxDb; Q86WQ0; -.
DR PeptideAtlas; Q86WQ0; -.
DR PRIDE; Q86WQ0; -.
DR ProteomicsDB; 5323; -.
DR ProteomicsDB; 70189; -. [Q86WQ0-1]
DR TopDownProteomics; Q86WQ0-1; -. [Q86WQ0-1]
DR Antibodypedia; 28401; 166 antibodies from 23 providers.
DR DNASU; 126382; -.
DR Ensembl; ENST00000331552.12; ENSP00000332823.6; ENSG00000184162.15. [Q86WQ0-1]
DR Ensembl; ENST00000420605.7; ENSP00000402756.1; ENSG00000184162.15. [Q86WQ0-2]
DR GeneID; 126382; -.
DR KEGG; hsa:126382; -.
DR MANE-Select; ENST00000331552.12; ENSP00000332823.6; NM_176880.6; NP_795361.1.
DR UCSC; uc002nlx.4; human. [Q86WQ0-1]
DR CTD; 126382; -.
DR DisGeNET; 126382; -.
DR GeneCards; NR2C2AP; -.
DR HGNC; HGNC:30763; NR2C2AP.
DR HPA; ENSG00000184162; Low tissue specificity.
DR MIM; 608719; gene.
DR neXtProt; NX_Q86WQ0; -.
DR OpenTargets; ENSG00000184162; -.
DR PharmGKB; PA162398172; -.
DR VEuPathDB; HostDB:ENSG00000184162; -.
DR eggNOG; ENOG502RZAY; Eukaryota.
DR GeneTree; ENSGT00390000017748; -.
DR HOGENOM; CLU_133965_0_0_1; -.
DR InParanoid; Q86WQ0; -.
DR OMA; FGRITVY; -.
DR OrthoDB; 1412628at2759; -.
DR PhylomeDB; Q86WQ0; -.
DR TreeFam; TF300180; -.
DR PathwayCommons; Q86WQ0; -.
DR Reactome; R-HSA-383280; Nuclear Receptor transcription pathway.
DR SignaLink; Q86WQ0; -.
DR BioGRID-ORCS; 126382; 321 hits in 1095 CRISPR screens.
DR ChiTaRS; NR2C2AP; human.
DR GenomeRNAi; 126382; -.
DR Pharos; Q86WQ0; Tbio.
DR PRO; PR:Q86WQ0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q86WQ0; protein.
DR Bgee; ENSG00000184162; Expressed in cortical plate and 151 other tissues.
DR ExpressionAtlas; Q86WQ0; baseline and differential.
DR Genevisible; Q86WQ0; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR SUPFAM; SSF49785; SSF49785; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..139
FT /note="Nuclear receptor 2C2-associated protein"
FT /id="PRO_0000295585"
FT VAR_SEQ 139
FT /note="V -> GTNRDPCRDLHYRAKLGEPRTHPRNLNFP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056072"
SQ SEQUENCE 139 AA; 15876 MW; D7BA1228FE9AA66E CRC64;
MTHSLVCPET VSRVSSVLNR NTRQFGKKHL FDQDEETCWN SDQGPSQWVT LEFPQLIRVS
QLQIQFQGGF SSRRGCLEGS QGTQALHKIV DFYPEDNNSL QTFPIPAAEV DRLKVTFEDA
TDFFGRVVIY HLRVLGEKV
