NR2CA_MOUSE
ID NR2CA_MOUSE Reviewed; 140 AA.
AC Q3TV70;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Nuclear receptor 2C2-associated protein;
DE AltName: Full=TR4 orphan receptor-associated 16 kDa protein;
GN Name=Nr2c2ap; Synonyms=Tra16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May act as a repressor of NR2C2-mediated transactivation by
CC suppressing the binding between NR2C2/TR4 and the TR4-response element
CC in target genes. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with NR2C2/TR4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NR2C2AP family. {ECO:0000305}.
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DR EMBL; AK160346; BAE35750.1; -; mRNA.
DR CCDS; CCDS40366.1; -.
DR RefSeq; NP_001020757.1; NM_001025586.2.
DR RefSeq; NP_001020758.1; NM_001025587.2.
DR AlphaFoldDB; Q3TV70; -.
DR SMR; Q3TV70; -.
DR STRING; 10090.ENSMUSP00000092907; -.
DR iPTMnet; Q3TV70; -.
DR PhosphoSitePlus; Q3TV70; -.
DR EPD; Q3TV70; -.
DR MaxQB; Q3TV70; -.
DR PaxDb; Q3TV70; -.
DR PeptideAtlas; Q3TV70; -.
DR PRIDE; Q3TV70; -.
DR ProteomicsDB; 253010; -.
DR Antibodypedia; 28401; 166 antibodies from 23 providers.
DR DNASU; 75692; -.
DR Ensembl; ENSMUST00000095273; ENSMUSP00000092907; ENSMUSG00000071078.
DR GeneID; 75692; -.
DR KEGG; mmu:75692; -.
DR UCSC; uc033jfy.1; mouse.
DR CTD; 126382; -.
DR MGI; MGI:1922942; Nr2c2ap.
DR VEuPathDB; HostDB:ENSMUSG00000071078; -.
DR eggNOG; ENOG502RZAY; Eukaryota.
DR GeneTree; ENSGT00390000017748; -.
DR HOGENOM; CLU_133965_0_0_1; -.
DR InParanoid; Q3TV70; -.
DR OMA; FGRITVY; -.
DR PhylomeDB; Q3TV70; -.
DR TreeFam; TF300180; -.
DR BioGRID-ORCS; 75692; 10 hits in 44 CRISPR screens.
DR ChiTaRS; Nr2c2ap; mouse.
DR PRO; PR:Q3TV70; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q3TV70; protein.
DR Bgee; ENSMUSG00000071078; Expressed in ectoplacental cone and 221 other tissues.
DR ExpressionAtlas; Q3TV70; baseline and differential.
DR Genevisible; Q3TV70; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR SUPFAM; SSF49785; SSF49785; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..140
FT /note="Nuclear receptor 2C2-associated protein"
FT /id="PRO_0000295586"
SQ SEQUENCE 140 AA; 15857 MW; 46BFA0DF6124D94C CRC64;
MTQSLVCPDT VSRVSSVLNR NSRQFGKKHL FDQDEETCWN SDQGPSQWVS LEFPQCVQIT
QLQVQFQGGF SSRHSCLEGS RGGEALSKIV DFYPEDTNAL QTFSIPTMEV DRLKLTFEDT
TDFFGRVVIY HLRVLGEKAG
