ID   NR2E1_CHICK             Reviewed;         385 AA.
AC   Q91379;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Nuclear receptor subfamily 2 group E member 1;
DE   AltName: Full=Nuclear receptor TLX;
DE   AltName: Full=Protein tailless homolog;
DE            Short=Tll;
GN   Name=NR2E1; Synonyms=TLX;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8047143; DOI=10.1038/370375a0;
RA   Yu R.T., McKeown M., Evans R.M., Umesono K.;
RT   "Relationship between Drosophila gap gene tailless and a vertebrate nuclear
RT   receptor Tlx.";
RL   Nature 370:375-379(1994).
RN   [2]
RP   FUNCTION.
RX   PubMed=10706625; DOI=10.1073/pnas.050566897;
RA   Yu R.T., Chiang M.-Y., Tanabe T., Kobayashi M., Yasuda K., Evans R.M.,
RA   Umesono K.;
RT   "The orphan nuclear receptor Tlx regulates Pax2 and is essential for
RT   vision.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:2621-2625(2000).
CC   -!- FUNCTION: Orphan receptor that binds DNA as a monomer to hormone
CC       response elements (HRE) containing an extended core motif half-site
CC       sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate
CC       in determining receptor specificity. May be required to pattern
CC       anterior brain differentiation (By similarity). Involved in the
CC       regulation of retinal development. {ECO:0000250,
CC       ECO:0000269|PubMed:10706625}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in the neuroepithelium of the
CC       embryonic brain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; S72373; AAB31467.1; -; mRNA.
DR   PIR; S48074; S48074.
DR   RefSeq; NP_990501.1; NM_205170.1.
DR   AlphaFoldDB; Q91379; -.
DR   SMR; Q91379; -.
DR   STRING; 9031.ENSGALP00000036481; -.
DR   GeneID; 396082; -.
DR   KEGG; gga:396082; -.
DR   CTD; 7101; -.
DR   VEuPathDB; HostDB:geneid_396082; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   InParanoid; Q91379; -.
DR   OrthoDB; 870262at2759; -.
DR   PhylomeDB; Q91379; -.
DR   PRO; PR:Q91379; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW   Receptor; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..385
FT                   /note="Nuclear receptor subfamily 2 group E member 1"
FT                   /id="PRO_0000053594"
FT   DOMAIN          155..383
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        16..83
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         16..36
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         52..78
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   385 AA;  42484 MW;  0AE6C4C533440BCC CRC64;
     MSKPAGSTSR ILDIPCKVCG DRSSGKHYGV YACDGCSGFF KRSIRRNRTY VCKSGNQGGC
     PVDKTHRNQC RACRLKKCLE VNMNKDAVQH ERGPRTSTIR KQVALYFRGH KEESSGAPHF
     PATALPAPAF FTAVSQLEPH GLELAAVAGT PERQALVGLA QPTPKYPHEV NGTPMYLYEV
     ATESVCESAA RLLFMSIKWA KSVPAFSTLS LQDQLMLLED AWRELFVLGI AQWAIPVDAN
     TLLAVSGMNG DNTDSQKLNK IISEIQALQE VVARFRQLRL DATEFACLKC IVTFKAVPTH
     SGSELRSFRN AAAIAALQDE AQLTLNSYIH TRYPTQPCRF GKLLLLLPAL RSISPSTIEE
     VFFKKTIGNV PITRLLSDMY KSSDI