ID   NR2E1_ORYLA             Reviewed;         396 AA.
AC   Q9YGL3;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Nuclear receptor subfamily 2 group E member 1;
DE   AltName: Full=Nuclear receptor TLX;
DE   AltName: Full=Protein tailless homolog;
DE            Short=Tll;
GN   Name=nr2e1; Synonyms=tll, tlx;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Henrich T., Loosli F., Wittbrodt J.;
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Orphan receptor that binds DNA as a monomer to hormone
CC       response elements (HRE) containing an extended core motif half-site
CC       sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate
CC       in determining receptor specificity. May be involved in the regulation
CC       of early eye development. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AJ131390; CAB38085.1; -; mRNA.
DR   RefSeq; NP_001098343.1; NM_001104873.1.
DR   AlphaFoldDB; Q9YGL3; -.
DR   SMR; Q9YGL3; -.
DR   STRING; 8090.ENSORLP00000016838; -.
DR   GeneID; 100049530; -.
DR   KEGG; ola:100049530; -.
DR   CTD; 7101; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   InParanoid; Q9YGL3; -.
DR   OrthoDB; 870262at2759; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..396
FT                   /note="Nuclear receptor subfamily 2 group E member 1"
FT                   /id="PRO_0000053595"
FT   DOMAIN          153..394
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        24..101
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         27..47
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         63..89
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   396 AA;  43907 MW;  F0138410AFE98553 CRC64;
     MSKPTGSTSG CLDILNVKSS RILDIPCKVC GDRSSGKHYG VYACDGCSGF FKRSIRRNRI
     YLCKSGSQGG CPVDKTHRNQ CRACRLKKCL EVNMNKDAVQ HERGPRTSTI RKQVALYFRG
     HKEVNGSSTH FPGSSLPGPP FFTTVTQLEP HNLEMSSVAT TPERQAIVGL AQPTPKYPHE
     VSGTPMYLYE VATESVCESA ARLLFMSIKW AKSVPAFSTL PLSDQLILLE DAWRELFVLG
     IAQWAIPVDS TTLLAVSGLN SENMEAQRMN KIMAEIQALQ EVVTRFRQMR LDATEFACLK
     CIVTFKAVPT QGSAELRAFR NASAIAALQD EAQLTLNSYI HTRYPTQPCR FGKLLLLLPA
     LRSVSPSTIE EVFFKKNIGN VPITRLLSDM YKSSDI