ID   NR2E1_XENLA             Reviewed;         386 AA.
AC   P70052;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Nuclear receptor subfamily 2 group E member 1;
DE   AltName: Full=Nuclear receptor TLX;
DE   AltName: Full=Protein tailless homolog;
DE            Short=Tll;
DE            Short=xTLL;
GN   Name=nr2e1; Synonyms=tll, tlx;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9609825; DOI=10.1242/dev.125.13.2425;
RA   Hollemann T., Bellefroid E., Pieler T.;
RT   "The Xenopus homologue of the Drosophila gene tailless has a function in
RT   early eye development.";
RL   Development 125:2425-2432(1998).
CC   -!- FUNCTION: Orphan receptor that binds DNA as a monomer to hormone
CC       response elements (HRE) containing an extended core motif half-site
CC       sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate
CC       in determining receptor specificity (By similarity). Involved in the
CC       regulation of early eye development. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- TISSUE SPECIFICITY: Prominent expression in the embryonal optic stalk
CC       and the distal tip of the forming vesicle. In tadpole-stage embryos
CC       predominantly found in the ciliary margin of the optic cup.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U67886; AAB07732.1; -; mRNA.
DR   RefSeq; NP_001079280.1; NM_001085811.1.
DR   AlphaFoldDB; P70052; -.
DR   SMR; P70052; -.
DR   GeneID; 378567; -.
DR   KEGG; xla:378567; -.
DR   CTD; 378567; -.
DR   Xenbase; XB-GENE-864991; nr2e1.S.
DR   OrthoDB; 870262at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 378567; Expressed in neurula embryo and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..386
FT                   /note="Nuclear receptor subfamily 2 group E member 1"
FT                   /id="PRO_0000053596"
FT   DOMAIN          155..384
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        13..90
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         16..36
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         52..78
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   386 AA;  42974 MW;  0ACE0922F3668172 CRC64;
     MSNPTGSTSR ILDIPCKVCG DRSSGKHYGV YACDGCSGFF KRSIRRNRSY VCKSGNQGGC
     PVDKTHRNQC RACRLKKCLE VNMNKDAVQH ERGPRTSTIR KQVALYFRGH KEVNGSTQHF
     SSTALPTPTF FTTVRQLEAH NLELAAISTV PERQTLVGLA QPTPKYPHEV NGAPLYLYEF
     ATESVCESAA RLLFMSIKWA KSVPAFSTLS LQDQLMLLED AWRELFVLGI AQWAIPVDAS
     TLLAVSGMNN ENTESPKLNK IISEIQALQD VVSRFRQLRL DATEFACLKC IVTFKAGVST
     HSGSELRNFR NAAAISALQD EAQLTLNSYI HTRYPTQPCR FGKLLLLLPA LRSINPSTIE
     EVFFKKTIGN VPITRVLSDM YKSSDI