ID   NR2F5_DANRE             Reviewed;         403 AA.
AC   Q06726;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Nuclear receptor subfamily 2 group F member 5;
DE   AltName: Full=Steroid receptor homolog SVP 46;
GN   Name=nr2f5; Synonyms=svp46;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8467797; DOI=10.1002/j.1460-2075.1993.tb05784.x;
RA   Fjose A., Nornes S., Weber U., Mlodzik M.;
RT   "Functional conservation of vertebrate seven-up related genes in
RT   neurogenesis and eye development.";
RL   EMBO J. 12:1403-1414(1993).
CC   -!- FUNCTION: Putative receptor that is required in photoreceptor cells
CC       precursors during eye development.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X70300; CAA49781.1; -; mRNA.
DR   PIR; S35334; S35334.
DR   RefSeq; NP_571261.1; NM_131186.1.
DR   AlphaFoldDB; Q06726; -.
DR   SMR; Q06726; -.
DR   STRING; 7955.ENSDARP00000040768; -.
DR   PaxDb; Q06726; -.
DR   Ensembl; ENSDART00000040769; ENSDARP00000040768; ENSDARG00000033172.
DR   GeneID; 30427; -.
DR   KEGG; dre:30427; -.
DR   CTD; 30427; -.
DR   ZFIN; ZDB-GENE-990415-253; nr2f5.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000165753; -.
DR   HOGENOM; CLU_007368_20_1_1; -.
DR   InParanoid; Q06726; -.
DR   OMA; NDPYNGQ; -.
DR   OrthoDB; 666130at2759; -.
DR   PhylomeDB; Q06726; -.
DR   TreeFam; TF352097; -.
DR   PRO; PR:Q06726; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000033172; Expressed in somite and 71 other tissues.
DR   ExpressionAtlas; Q06726; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:1904888; P:cranial skeletal system development; IGI:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0032526; P:response to retinoic acid; IMP:ZFIN.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Sensory transduction; Transcription; Transcription regulation; Vision;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..403
FT                   /note="Nuclear receptor subfamily 2 group F member 5"
FT                   /id="PRO_0000053612"
FT   DOMAIN          152..378
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        51..126
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         54..74
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         90..114
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          16..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  45081 MW;  0848319E2EBEEE62 CRC64;
     MAMVVNQWQE NISADPGSQL QMCSQEPGGT PGTPSGSTPG NDALSGDKIP NVDCMVCGDK
     SSGKHYGQFT CEGCKSFFKR SVRRNLSYTC RGNRDCPIDQ HHRNQCQYCR LKKCLKVGMR
     REAVQRGRMS NSQSSPGQYL SNGSDPYNGQ PYLSGFISLL LRAEPYPTSR YGAQCMQSNN
     LMGIENICEL AARLLFSAVE WAKNIPFFPD LQLMDQVALL RMSWSELFVL NAAQCSMPLH
     VAPLLAAAGL HASPMSAERV VAFMDHIRVF QEQVEKLKAL QVDTAEYSCL KSIVLFTSDA
     MGLSDVAHVE SIQEKSQCAL EEYVRNQYPN QPNRFGRLLL RLPSLRIVSS PVIEQLFFVR
     LVGKTPIETL LRDMLLSGSS YNWPYMPVQR DRPISIHYNE NGP