NR2F6_RAT
ID NR2F6_RAT Reviewed; 390 AA.
AC O09017;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 147.
DE RecName: Full=Nuclear receptor subfamily 2 group F member 6;
DE AltName: Full=COUPg;
DE AltName: Full=Ovalbumin upstream promoter gamma nuclear receptor;
DE AltName: Full=V-erbA-related protein 2;
DE Short=EAR-2;
GN Name=Nr2f6; Synonyms=Ear2, Erbal2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RA Boutin J.-M., Ronsin B., Devost D., Lipkin S.M., Rosenfeld M.G., Morel G.;
RT "Cloning and expression of COUPb and COUPg in the rat anterior pituitary.";
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION.
RX PubMed=9343308; DOI=10.1677/jme.0.0190163;
RA Chu K., Zingg H.H.;
RT "The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the
RT human oxytocin gene promoter.";
RL J. Mol. Endocrinol. 19:163-172(1997).
CC -!- FUNCTION: Transcription factor predominantly involved in
CC transcriptional repression. Binds to promoter/enhancer response
CC elements that contain the imperfect 5'-AGGTCA-3' direct or inverted
CC repeats with various spacings which are also recognized by other
CC nuclear hormone receptors. Involved in modulation of hormonal
CC responses. Represses transcriptional activity of the lutropin-
CC choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and
CC the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-
CC dependent and -independent transcriptional activity of the thyroid
CC hormone receptor gene in a cell type-specific manner. The corepressing
CC function towards thyroid hormone receptor beta/THRB involves at least
CC in part the inhibition of THRB binding to triiodothyronine response
CC elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA
CC binding and subsequently its transcriptional activity. Acts as
CC transcriptional repressor of IL-17 expression in Th-17 differentiated
CC CD4(+) T cells and may be involved in induction and/or maintenance of
CC peripheral immunological tolerance and autoimmunity. Involved in
CC development of forebrain circadian clock; is required early in the
CC development of the locus coeruleus (LC) (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:9343308}.
CC -!- SUBUNIT: Binds DNA as dimer; homodimer and heterodimer with NR2F2 and
CC probably NR2F1. Interacts with THRB (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000305}.
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DR EMBL; AF003926; AAB61296.1; -; mRNA.
DR RefSeq; NP_620813.1; NM_139113.1.
DR AlphaFoldDB; O09017; -.
DR SMR; O09017; -.
DR STRING; 10116.ENSRNOP00000022898; -.
DR PhosphoSitePlus; O09017; -.
DR PaxDb; O09017; -.
DR GeneID; 245980; -.
DR KEGG; rno:245980; -.
DR UCSC; RGD:621685; rat.
DR CTD; 2063; -.
DR RGD; 621685; Nr2f6.
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; O09017; -.
DR OrthoDB; 666130at2759; -.
DR PhylomeDB; O09017; -.
DR Reactome; R-RNO-383280; Nuclear Receptor transcription pathway.
DR PRO; PR:O09017; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; ISO:RGD.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0048666; P:neuron development; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Receptor;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1..390
FT /note="Nuclear receptor subfamily 2 group F member 6"
FT /id="PRO_0000053615"
FT DOMAIN 157..380
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 54..129
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 57..77
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 93..117
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..390
FT /note="Important for dimerization"
FT /evidence="ECO:0000250"
FT MOD_RES 35
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P43136"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P10588"
SQ SEQUENCE 390 AA; 41730 MW; B08FAC93F76A7783 CRC64;
MAMVTGGWGG PGGDTNGVDK AGGSYPRATE DDSASPPGAT SDAEPGDEER PGLQVDCVVC
GDKSSGKHYG VFTCEGCKSF FKRTIRRNLS YTCRSNRDCQ IDQHHRNQCQ YCRLKKCFRV
GMRKEAVQPG PIPHALPGPA ACSPPGAAGV EPFAGPPVSE LIAQLLRAEP YPAAGRFGGG
GAVLGIDNVC ELAARLLFST VEWARHAPFF PELPAADQVG LLRLSWSELF VLNAAQAPVP
LHTAPLLAAA GLHAGPMAAE RAVAFMDQVR AFQEQVDKLG RLQVDAAEYG CLKAIALFTP
DACGLSDPAH VESLQEKAQV ALTEYVRAQY PSQPQRFGRL LLRLPALRAV PASLISQLFF
MRLVGKTPIE TLIRDMLLSG STFNWPYGSG
