NR3BA_DANRE
ID NR3BA_DANRE Reviewed; 1686 AA.
AC A1XQY1; A1XQY2;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Neurexin-3b;
DE AltName: Full=Neurexin IIIb-alpha;
DE AltName: Full=Neurexin-3b-alpha;
DE Flags: Precursor;
GN Name=nrxn3b;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 2A), DEVELOPMENTAL STAGE, AND
RP ALTERNATIVE SPLICING.
RX PubMed=17041151; DOI=10.1093/molbev/msl147;
RA Rissone A., Monopoli M., Beltrame M., Bussolino F., Cotelli F., Arese M.;
RT "Comparative genome analysis of the neurexin gene family in Danio rerio:
RT insights into their functions and evolution.";
RL Mol. Biol. Evol. 24:236-252(2007).
CC -!- FUNCTION: Neuronal cell surface protein that may be involved in cell
CC recognition and cell adhesion.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=3;
CC Comment=A number of isoforms, alpha-type and beta-type are produced
CC by alternative promoter usage. Beta-type isoforms differ from
CC alpha-type isoforms in their N-terminus.;
CC Name=1a;
CC IsoId=A1XQY1-1; Sequence=Displayed;
CC Name=2a; Synonyms=Soluble form;
CC IsoId=A1XQY1-2; Sequence=VSP_041708, VSP_041709;
CC Name=1b;
CC IsoId=A1XQY3-1; Sequence=External;
CC -!- DEVELOPMENTAL STAGE: After the very early developmental stages, the
CC expression levels decrease and remain relatively constant until around
CC 24 h, with the onset of an increase of expression that continues till
CC the larval stages. {ECO:0000269|PubMed:17041151}.
CC -!- MISCELLANEOUS: [Isoform 2a]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the neurexin family. {ECO:0000305}.
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DR EMBL; DQ641435; ABG25172.1; -; mRNA.
DR EMBL; DQ641436; ABG25173.1; -; mRNA.
DR RefSeq; NP_001073516.1; NM_001080047.1.
DR AlphaFoldDB; A1XQY1; -.
DR SMR; A1XQY1; -.
DR STRING; 7955.ENSDARP00000107689; -.
DR PaxDb; A1XQY1; -.
DR GeneID; 570698; -.
DR KEGG; dre:570698; -.
DR CTD; 570698; -.
DR ZFIN; ZDB-GENE-070206-10; nrxn3b.
DR eggNOG; KOG3514; Eukaryota.
DR InParanoid; A1XQY1; -.
DR OrthoDB; 35129at2759; -.
DR PhylomeDB; A1XQY1; -.
DR ChiTaRS; nrxn3b; zebrafish.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00110; LamG; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR InterPro; IPR027789; Syndecan/Neurexin_dom.
DR Pfam; PF02210; Laminin_G_2; 6.
DR Pfam; PF01034; Syndecan; 1.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; SSF49899; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 2: Evidence at transcript level;
KW Alternative promoter usage; Alternative splicing; Angiogenesis; Calcium;
KW Cell adhesion; Disulfide bond; EGF-like domain; Membrane; Metal-binding;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1686
FT /note="Neurexin-3b"
FT /id="PRO_0000412553"
FT TOPO_DOM 24..1610
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1611..1631
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1632..1686
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 24..198
FT /note="Laminin G-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 194..231
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 254..451
FT /note="Laminin G-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 458..650
FT /note="Laminin G-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 654..691
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 696..859
FT /note="Laminin G-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 876..1048
FT /note="Laminin G-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 1051..1088
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1092..1292
FT /note="Laminin G-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT REGION 1324..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1501..1545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1653..1668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1669..1686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 300
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 317
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 380
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT DISULFID 198..209
FT /evidence="ECO:0000250"
FT DISULFID 203..218
FT /evidence="ECO:0000250"
FT DISULFID 220..230
FT /evidence="ECO:0000250"
FT DISULFID 415..451
FT /evidence="ECO:0000250"
FT DISULFID 621..650
FT /evidence="ECO:0000250"
FT DISULFID 658..669
FT /evidence="ECO:0000250"
FT DISULFID 663..678
FT /evidence="ECO:0000250"
FT DISULFID 680..690
FT /evidence="ECO:0000250"
FT DISULFID 1020..1048
FT /evidence="ECO:0000250"
FT DISULFID 1055..1066
FT /evidence="ECO:0000250"
FT DISULFID 1060..1075
FT /evidence="ECO:0000250"
FT DISULFID 1077..1087
FT /evidence="ECO:0000250"
FT VAR_SEQ 1368..1403
FT /note="GGELVIPVLVEDPIDIPPISTRVPFIPLPPTLHPVL -> AQSSFATRTLRT
FT ALTWTWQLMYTFTSIYFISYLVCS (in isoform 2a)"
FT /evidence="ECO:0000303|PubMed:17041151"
FT /id="VSP_041708"
FT VAR_SEQ 1404..1686
FT /note="Missing (in isoform 2a)"
FT /evidence="ECO:0000303|PubMed:17041151"
FT /id="VSP_041709"
FT CONFLICT 1013
FT /note="P -> S (in Ref. 1; ABG25173)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1686 AA; 185768 MW; 5A273F4741B68073 CRC64;
MPPHCQPHCV LLLLSTFLSL GLGLEFTGSE GQWARYLRWD ASTRSDLSFQ FKTAISDALV
LYFDDGGYCD FLLLSIEDAK LKLRFSVDCA ETTITSDKMV NDSHWHFATI SRHNLRTVLA
LDGDSKVDEV RPQRQFMKIV SDLYLGGVPQ DIRTSALTLP AAKEMPPFKG IITDLGYGNK
VPTRLGSQKV RLEMEGFCTE NPCENGGSCS MADGEAYCDC SKTGYTGRYC NEAVNKTPGF
AHMVKSPQAR EENVATFRGS EYFCYDLSQN PIQSSSDEIT LSFKTWQRNG LILHTGKSAD
YVNLALKDGA VSLVINLGSG AFEAIVEPVN GKFNDNAWHD IKVTRNLRQH SGIGHAMVNK
LHCLVTISVD GILTTTGYTQ EDYTMLGSDD FFYVGGSPST ADLPGSPVSN NFMGCLKEVV
YKNNDIRLEL SRLARIADPK MKLQGDIVFK CENVPTLDPI SFETAESFLG LPKWNTKRVG
SISFDFRTSE PNGLILFTQG KPQDKKDSRS QRSNKVDFFA VELLDGHLYL LLDMGSGTIK
VKATQNKVND GVWHHVDIQR DGRSGIISVN SRRTPFTASG ENEILDLEGN LYLGGLPDNR
ADLILPTELW TAMLNYGYVG CIRDLFIDGR SKDIRQIAEA QNVGGIKSSC SKVTAKQCDS
NSCKNNGICK EGWNRFICDC TGTGYWDRTC EREASILSYD GSMYMKVVMP TIIHTEAEDV
SLRFMSQRAF GLLMAATSRE SADTLRLELD SGRVKLIVNL GKGPETLYAG QKVNDNDWHS
VRVTRRGKNI KLMVDDDVAE GQMNGDHTRL EFSNVETGIL TERRFASTAP SNFIGHLQGL
KFNGLLYIDM CKNGDIEFCE LNARFGMRSI VADPVTFKTK GSYLGLATLQ AYSTMHLFFQ
FKTTSGDGFI LFNSGDGNDF IAVELVKGYI HYVFNLGNGP SLLKGNSDSP LNDNQWHNVV
ITRDASNTHT LKVDAKSVSQ VVNGAKNLDL KGDLFVAGLG PNMYQNLPKL VVPREGFQGC
LASMDLNGRL PDLINDALFR SGQIERGCEG PSTTCQEDSC ANMGVCIQQW ENFTCDCSMT
SYSGTQCNDP GATYIFGKGG GLIMYTWPNN ERPSTRTDRL AVGFSTTIKD GILVRIDSAP
RLGDYIMLHI EEGKVCVTFN IGTVDISVKE MTTEVNDGKY HVVRFTRNGG NATLQVDNWP
INEHFPSGNS DIERFQMANK KIPFKYTRPV EDWLHEKDRQ LTIFNTQATI SIGGNDRKRP
YQGQLSGLYY NGLKVLNMAA EGHTNIKING SVRLVGDVPT SRSPSRTTTS MPPEMSTTFI
ETTTTLSTTT TRKQRSPPTI QTTDDIVSSA ECSSDDEDLE ECDGGHTGGE LVIPVLVEDP
IDIPPISTRV PFIPLPPTLH PVLTIIETTK ESLSIATEAG VPCFSDQGRD DCDDDDGDDD
DGDGLVISGF GSGEVFDSSL PPTDDEDFYT TFSLVTDKIL TTSTYEGGYK ALAPKWEEKD
FKPKKPSEVG RITAIPPLPD LRSSAASPVR PEPAPKIPAG KMNNREVKPQ PDIVLLPLPT
SFDMDGTKPK GPYITQPMLR TIPSALPTVP GIRRVPPGAS EVIRESSSTT GMVVGIVSAA
ALCILILLYA MYKYRNRDEG SYQVDETRNY ISNSAQNNGT VVKDKQPSTK GASNKRPKDK
DKEYYV
