ID   NR4A1_XENLA             Reviewed;         577 AA.
AC   Q04913;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Nuclear receptor subfamily 4 group A member 1;
DE   AltName: Full=Nerve growth factor-induced protein I-B homolog;
GN   Name=nr4a1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neurula;
RX   PubMed=8504173; DOI=10.1016/0167-4781(93)90189-k;
RA   Smith T.S., Matharu P.J., Sweeney G.E.;
RT   "Cloning and sequencing of a Xenopus homologue of the inducible orphan
RT   receptor NGFI-B.";
RL   Biochim. Biophys. Acta 1173:239-242(1993).
CC   -!- FUNCTION: Probable nuclear receptor. {ECO:0000250|UniProtKB:P22736}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P22736}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P22736}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR4
CC       subfamily. {ECO:0000305}.
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DR   EMBL; X70700; CAA50031.1; -; mRNA.
DR   PIR; S33763; S33763.
DR   AlphaFoldDB; Q04913; -.
DR   SMR; Q04913; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR003070; Nuc_orph_rcpt.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01284; NUCLEARECPTR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..577
FT                   /note="Nuclear receptor subfamily 4 group A member 1"
FT                   /id="PRO_0000053721"
FT   DOMAIN          339..574
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        243..318
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         246..266
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         282..311
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   577 AA;  64383 MW;  3A6B26EA20EA8FB1 CRC64;
     MPCIQAQHGS LSQCAGPCDN YVPDILNSEF GKFTMDLVNS EIAASTSLPS FSTFMDGYTG
     EFDAFLYQIP SSNQQSSLKV EEFQVFGCYP GSFTNQLDET MSSSGSDYYG SPCSIPSPST
     PGFQNPQLPT WECSYGAYSP TQNYDNMRHW TEQQKNSISQ QTFFSFGTPA HSPNMAANPL
     KIAPATHRLD QQLVDTDVFA LAQNSSAGFP AVPLGQAPGV LDSSVLLDSP LSPSKTRSPS
     SNEGRCAVCG DNASCQHYGV RTCEGCKGFF KRTVQKNAKY ICLANKDCPV DKRRRNRCQF
     CRFQKCLVVG MVKEVVRTDS LKGRRGRLPS KPKQIAESSP VDLINSLVRA HIDSIPSSSK
     LDYSKFQETV PLQLEKESSV DVQQFYDLLS GSLEVIRKWA EKIQGFVDLP KEDQDLLLES
     AFLELFILRL AYRSRPEEGK LIFCNGVVLH RTQCVRGFGE WIDSIIEFSH SLQRMNIDVP
     SFSCLSALVI VTDRHGLKEP KKVEELQSQI INCLKEHIPS SMNEQNRPNC LSKLLGKLPE
     LRTLCTQGLQ RIFYLKLEDL VPPPPIVDKI FMDTLPF