NR4A2_RAT
ID NR4A2_RAT Reviewed; 598 AA.
AC Q07917; O35865;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1999, sequence version 3.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Nuclear receptor subfamily 4 group A member 2;
DE AltName: Full=NUR-related factor 1;
DE AltName: Full=Nuclear orphan receptor HZF-3;
DE AltName: Full=Orphan nuclear receptor NURR1;
DE AltName: Full=Regenerating liver nuclear receptor 1;
DE Short=RNR-1;
DE AltName: Full=SL-322;
GN Name=Nr4a2; Synonyms=Hzf-3, Nurr1, Rnr1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RX PubMed=7914660; DOI=10.1016/0169-328x(94)90235-6;
RA Pena de Ortiz S., Cannon M.M., Jamieson G.A. Jr.;
RT "Expression of nuclear hormone receptors within the rat hippocampus:
RT identification of novel orphan receptors.";
RL Brain Res. Mol. Brain Res. 23:278-283(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8473329; DOI=10.1016/s0021-9258(18)52952-5;
RA Scearce L.M., Laz T.M., Hazel T.G., Lau L.F., Taub R.;
RT "RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly
RT induced in regenerating liver.";
RL J. Biol. Chem. 268:8855-8861(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=9221923; DOI=10.1016/s0169-328x(97)00056-9;
RA Xing G.Q., Zhang L.X., Zhang L., Heynen T., Li X.L., Smith M.A.,
RA Weiss S.R.B., Feldman A.N., Detera-Wadleigh S., Chuang D.M., Post R.M.;
RT "Rat nurr1 is prominently expressed in perirhinal cortex, and
RT differentially induced in the hippocampal dentate gyrus by
RT electroconvulsive vs. kindled seizures.";
RL Brain Res. Mol. Brain Res. 47:251-261(1997).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=18951485; DOI=10.1002/jnr.21911;
RA Katunar M.R., Saez T., Brusco A., Antonelli M.C.;
RT "Immunocytochemical expression of dopamine-related transcription factors
RT Pitx3 and Nurr1 in prenatally stressed adult rats.";
RL J. Neurosci. Res. 87:1014-1022(2009).
CC -!- FUNCTION: Transcriptional regulator which is important for the
CC differentiation and maintenance of meso-diencephalic dopaminergic
CC (mdDA) neurons during development. It is crucial for expression of a
CC set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential
CC for development of mdDA neurons (By similarity). May confer liver-
CC specific regulation of delayed-early genes induced later in the G1
CC phase of regeneration along with HMR. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction
CC with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus. Note=Mostly
CC nuclear; oxidative stress promotes cytoplasmic localization.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Shows a ubiquitous distribution in the cerebral
CC cortex, hippocampus, thalamus, amygdala, and midbrain. Expression
CC increases in prenatally stressed adult offspring in the ventral
CC tegmental area, whereas no changes are observed in the substantia nigra
CC area (at protein level). Not expressed in quiescent liver but is
CC rapidly induced following partial hepatectomy and is specific to
CC hepatic growth as it is not induced in other mitogen-treated cells.
CC Expressed at very low levels in the lung, spleen and stomach and at
CC high levels in the brain. {ECO:0000269|PubMed:18951485}.
CC -!- DOMAIN: the ligand-binding domain (LBD) contains no cavity as a result
CC of the tight packing of side chains from several bulky hydrophobic
CC residues in the region normally occupied by ligands. NR4A2 lacks a
CC 'classical' binding site for coactivators (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR4
CC subfamily. {ECO:0000305}.
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DR EMBL; U01146; AAC52143.1; -; mRNA.
DR EMBL; L08595; AAA42058.1; -; mRNA.
DR EMBL; U72345; AAC53315.1; -; mRNA.
DR PIR; I84692; I84692.
DR RefSeq; NP_062201.2; NM_019328.3.
DR RefSeq; XP_006234263.1; XM_006234201.3.
DR RefSeq; XP_017447486.1; XM_017591997.1.
DR AlphaFoldDB; Q07917; -.
DR BMRB; Q07917; -.
DR SMR; Q07917; -.
DR IntAct; Q07917; 1.
DR STRING; 10116.ENSRNOP00000043812; -.
DR ChEMBL; CHEMBL4523278; -.
DR iPTMnet; Q07917; -.
DR PhosphoSitePlus; Q07917; -.
DR PaxDb; Q07917; -.
DR PRIDE; Q07917; -.
DR GeneID; 54278; -.
DR KEGG; rno:54278; -.
DR CTD; 4929; -.
DR RGD; 3202; Nr4a2.
DR eggNOG; KOG4217; Eukaryota.
DR InParanoid; Q07917; -.
DR OrthoDB; 454476at2759; -.
DR PhylomeDB; Q07917; -.
DR TreeFam; TF315430; -.
DR Reactome; R-RNO-383280; Nuclear Receptor transcription pathway.
DR PRO; PR:Q07917; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0000785; C:chromatin; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0035259; F:nuclear glucocorticoid receptor binding; ISO:RGD.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0008344; P:adult locomotory behavior; ISO:RGD.
DR GO; GO:0071376; P:cellular response to corticotropin-releasing hormone stimulus; ISS:UniProtKB.
DR GO; GO:0031668; P:cellular response to extracellular stimulus; ISO:RGD.
DR GO; GO:0034599; P:cellular response to oxidative stress; ISO:RGD.
DR GO; GO:0021953; P:central nervous system neuron differentiation; ISO:RGD.
DR GO; GO:0021952; P:central nervous system projection neuron axonogenesis; ISO:RGD.
DR GO; GO:0021987; P:cerebral cortex development; IEP:RGD.
DR GO; GO:0042416; P:dopamine biosynthetic process; ISO:RGD.
DR GO; GO:0042417; P:dopamine metabolic process; ISO:RGD.
DR GO; GO:0071542; P:dopaminergic neuron differentiation; ISS:UniProtKB.
DR GO; GO:0045444; P:fat cell differentiation; ISS:UniProtKB.
DR GO; GO:0010467; P:gene expression; ISO:RGD.
DR GO; GO:0051866; P:general adaptation syndrome; ISO:RGD.
DR GO; GO:0021986; P:habenula development; ISO:RGD.
DR GO; GO:0007611; P:learning or memory; IMP:RGD.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; ISO:RGD.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0007399; P:nervous system development; ISO:RGD.
DR GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR GO; GO:0042551; P:neuron maturation; ISO:RGD.
DR GO; GO:0001764; P:neuron migration; ISO:RGD.
DR GO; GO:0043085; P:positive regulation of catalytic activity; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0009791; P:post-embryonic development; ISO:RGD.
DR GO; GO:0042053; P:regulation of dopamine metabolic process; ISO:RGD.
DR GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR GO; GO:0043576; P:regulation of respiratory gaseous exchange; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0001975; P:response to amphetamine; ISO:RGD.
DR GO; GO:0001666; P:response to hypoxia; ISO:RGD.
DR GO; GO:0010035; P:response to inorganic substance; IDA:MGI.
DR GO; GO:0017085; P:response to insecticide; IDA:MGI.
DR GO; GO:0060041; P:retina development in camera-type eye; IEP:RGD.
DR GO; GO:0006351; P:transcription, DNA-templated; ISS:UniProtKB.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR003070; Nuc_orph_rcpt.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR003073; NURR_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01284; NUCLEARECPTR.
DR PRINTS; PR01287; NURRNUCRCPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..598
FT /note="Nuclear receptor subfamily 4 group A member 2"
FT /id="PRO_0000053720"
FT DOMAIN 360..595
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 260..335
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 263..283
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 299..323
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 287..314
FT /note="Bipartite nuclear localization signal (NLS1)"
FT /evidence="ECO:0000250"
FT MOTIF 338..350
FT /note="Nuclear localization signal (NLS1)"
FT /evidence="ECO:0000250"
FT MOTIF 443..452
FT /note="nuclear export sequence (NES1)"
FT /evidence="ECO:0000250"
FT MOTIF 568..577
FT /note="nuclear export sequence (NES2)"
FT /evidence="ECO:0000250"
FT CONFLICT 182
FT /note="R -> A (in Ref. 2; AAA42058)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="R -> P (in Ref. 3; AAC53315)"
FT /evidence="ECO:0000305"
FT CONFLICT 250
FT /note="S -> P (in Ref. 2; AAA42058)"
FT /evidence="ECO:0000305"
FT CONFLICT 252
FT /note="P -> A (in Ref. 1; AAC52143)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="V -> G (in Ref. 2; AAA42058)"
FT /evidence="ECO:0000305"
FT CONFLICT 364..371
FT /note="LISALVRA -> DQCPRQT (in Ref. 2; AAA42058)"
FT /evidence="ECO:0000305"
FT CONFLICT 434
FT /note="D -> S (in Ref. 2; AAA42058)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 598 AA; 66622 MW; 0A54ED59FB70DEA8 CRC64;
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF
STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY QQHSHLPPQS EEMMPHSGSV
YYKPSSPPTP STPGFQVQHS PMWDDPGSLH NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ
SRPGTPVSSC QMRFDGPLHV PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA
SQLLDTQVPS PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK SPQDPSPPSP
PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT QHIQQFYDLL TGSMEIIRGW
AEKIPGFADL PKADQDLLFE SAFLELFVLR LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG
EWIDSIVEFS SNLQNMNIDI SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT
FNNGGLNRPN YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF
