NR4A2_XENTR
ID NR4A2_XENTR Reviewed; 591 AA.
AC A4IIG7;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Nuclear receptor subfamily 4 group A member 2;
GN Name=nr4a2;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator which may play a role in the
CC differentiation and maintenance of meso-diencephalic dopaminergic
CC (mdDA) neurons. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; BC136009; AAI36010.1; -; mRNA.
DR RefSeq; NP_001093678.1; NM_001100208.1.
DR AlphaFoldDB; A4IIG7; -.
DR SMR; A4IIG7; -.
DR PaxDb; A4IIG7; -.
DR DNASU; 100101682; -.
DR GeneID; 100101682; -.
DR KEGG; xtr:100101682; -.
DR CTD; 4929; -.
DR Xenbase; XB-GENE-480893; nr4a2.
DR eggNOG; KOG4217; Eukaryota.
DR HOGENOM; CLU_007368_14_2_1; -.
DR InParanoid; A4IIG7; -.
DR OMA; HAAGEYS; -.
DR OrthoDB; 454476at2759; -.
DR PhylomeDB; A4IIG7; -.
DR TreeFam; TF315430; -.
DR Reactome; R-XTR-383280; Nuclear Receptor transcription pathway.
DR Proteomes; UP000008143; Chromosome 9.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000031753; Expressed in brain and 10 other tissues.
DR ExpressionAtlas; A4IIG7; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0035259; F:nuclear glucocorticoid receptor binding; IBA:GO_Central.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071376; P:cellular response to corticotropin-releasing hormone stimulus; IBA:GO_Central.
DR GO; GO:0021953; P:central nervous system neuron differentiation; IBA:GO_Central.
DR GO; GO:0071542; P:dopaminergic neuron differentiation; IBA:GO_Central.
DR GO; GO:0021884; P:forebrain neuron development; IEA:Ensembl.
DR GO; GO:0001780; P:neutrophil homeostasis; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR003070; Nuc_orph_rcpt.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR003073; NURR_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01284; NUCLEARECPTR.
DR PRINTS; PR01287; NURRNUCRCPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..591
FT /note="Nuclear receptor subfamily 4 group A member 2"
FT /id="PRO_0000326153"
FT DOMAIN 353..588
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 253..328
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 256..276
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 292..311
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 280..307
FT /note="Bipartite nuclear localization signal (NLS1)"
FT /evidence="ECO:0000250"
FT MOTIF 331..343
FT /note="Nuclear localization signal (NLS1)"
FT /evidence="ECO:0000250"
FT MOTIF 436..445
FT /note="nuclear export sequence (NES1)"
FT /evidence="ECO:0000250"
FT MOTIF 561..570
FT /note="nuclear export sequence (NES2)"
FT /evidence="ECO:0000250"
FT COMPBIAS 112..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 65681 MW; E3DD191ED465C45C CRC64;
MPCVQAQYGS SPQGASPASQ SYTYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF
STFMDNYNTS YDVKPPCLYQ MPLSGQQSSV KVEDIQMHGY QQHGHLPPQS EEMMSHSGSV
YYKPSSPPTS STPGFPVQHS PMWDNHGSLH SFNQNYVATR GGHVPRLSLF SFKQSPPGTP
VSSCQMRFDG HHVSMNPETS GAHHVIDGQT FAVPNPIRKQ ASMGFPGLQL GHASQLIDSQ
VPSPPSRGSP SNEGLCAVCG DNAACQHYGV RTCEGCKGFF KRTVQKNAKY VCLANKNCPV
DKRRRNRCQY CRFQKCLVVG MVKEVVRTDS LKGRRGRLPS KPKSPQEPSP PSPPVSLISA
LVRAHVDSNP AVSSLDYSRF QANPEYQMNG DDTQHIQQFY DLLTGSMEII RGWAEKIPGF
SELHKQDQDL LFESAFLELF VLRLAYRSNP AEGKLIFCNG VVLNRLQCVR GFGEWIDSIV
DFSSNLHSMN IDISAFSCIA ALAVITERHG LKEPKRVEEL QNKIVNCLKD HVTFNNGGLN
RPNYLSKLLG KLPELRTLCT QGLQRIFYLK LEDLVPPPAI IDKLFLDTLP F
