ID   NR5A2_CHICK             Reviewed;         501 AA.
AC   O42101;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Nuclear receptor subfamily 5 group A member 2;
DE   AltName: Full=FTF/LRH-1;
DE   AltName: Full=OR2.0;
GN   Name=NR5A2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=9332374; DOI=10.1016/s0378-1119(97)00270-9;
RA   Kudo T., Sutou S.;
RT   "Molecular cloning of chicken FTZ-F1-related orphan receptors.";
RL   Gene 197:261-268(1997).
CC   -!- FUNCTION: Nuclear receptor that acts as a key metabolic sensor by
CC       regulating the expression of genes involved in bile acid synthesis,
CC       cholesterol homeostasis and triglyceride synthesis. Together with the
CC       oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an
CC       essential transcriptional regulator of lipid metabolism (By
CC       similarity). Activates the transcription of CYP2C38 (By similarity).
CC       {ECO:0000250|UniProtKB:O00482}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Detected in liver and adrenal gland.
CC       {ECO:0000269|PubMed:9332374}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AB002403; BAA22838.1; -; mRNA.
DR   RefSeq; NP_990409.1; NM_205078.1.
DR   AlphaFoldDB; O42101; -.
DR   SMR; O42101; -.
DR   STRING; 9031.ENSGALP00000003413; -.
DR   PaxDb; O42101; -.
DR   PRIDE; O42101; -.
DR   GeneID; 395961; -.
DR   KEGG; gga:395961; -.
DR   CTD; 2494; -.
DR   VEuPathDB; HostDB:geneid_395961; -.
DR   eggNOG; KOG4218; Eukaryota.
DR   InParanoid; O42101; -.
DR   PhylomeDB; O42101; -.
DR   PRO; PR:O42101; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR016355; NR5_fam.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24086; PTHR24086; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PIRSF; PIRSF002530; Nuc_orph_FTZ-F1; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..501
FT                   /note="Nuclear receptor subfamily 5 group A member 2"
FT                   /id="PRO_0000053737"
FT   DOMAIN          260..499
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        43..114
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         46..66
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         82..106
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          186..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           115..144
FT                   /note="FTZ-F1 box"
SQ   SEQUENCE   501 AA;  57103 MW;  734596FC25682771 CRC64;
     MLPKVETEAL GLARSNGEQG QMPENMQVSQ FKMVNYSYDE DLEELCPVCG DKVSGYHYGL
     LTCESCKGFF KRTVQNNKRY TCIENQNCQI DKTQRKRCPY CRFQKCLSVG MKLEAVRADR
     MRGGRNKFGP MYKRDRALKQ QKKALIRANG LKLEAMTQVI QAMPTDLTIS SAIQNIHSAS
     KGLPLNHTAL PPTDYDRSPF VTSPISMTMP PHGSLQGYQT YGHFPSRAIK SEYPDPYTSS
     PESIMGYSYM DGYQTSSPAS IPHLILELQK CEPDEPQVQA KIMAYLQQEQ ANRSKHEKLN
     TFGLMCKMAD QTLFSIVEWA RSSIFFRELK VDDQMKLLQN CWSELLILDH IYRQVVHVKE
     GSILLVTGQQ VDYSVIASQA GATLNNLMSH AQELVAKLRS LQFDLREFVC LKFLVLFSLD
     VKNLENFQLV EGVQEQVNAA LLDYTMCNYP QQTDKFGQLL LRLPEIRAIS MQAEEYLYCK
     HLNGDVPCNN LLIEMLHAKR A