NR6A1_PIG
ID NR6A1_PIG Reviewed; 479 AA.
AC A0P8Z4;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Nuclear receptor subfamily 6 group A member 1;
DE AltName: Full=Germ cell nuclear factor;
DE Short=GCNF;
GN Name=NR6A1; Synonyms=GCNF;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT LEU-192, CHARACTERIZATION
RP OF VARIANT LEU-192, AND INTERACTION WITH UIMC1.
RC STRAIN=Large white X Landrace X Duroc;
RX PubMed=17416745; DOI=10.1101/gr.6085507;
RA Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M.,
RA Okumura N., Awata T.;
RT "Fine mapping of a swine quantitative trait locus for number of vertebrae
RT and analysis of an orphan nuclear receptor, germ cell nuclear factor
RT (NR6A1).";
RL Genome Res. 17:586-593(2007).
CC -!- FUNCTION: Orphan nuclear receptor. Binds to a response element
CC containing the sequence 5'-TCAAGGTCA-3'. May be involved in the
CC regulation of gene expression in germ cell development during
CC gametogenesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with UIMC1 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- POLYMORPHISM: The polymorphism in position 192 seems to be responsible
CC for the increase in number of vertebrae in domestic pigs. Wild boars
CC uniformly have 19 vertebrae, while European commercial breeds have 21
CC to 23 vertebrae The ancestral form with Leu-192 has a 3 times lower
CC binding activity to UIMC1 than Pro-192. The binding to NCOR1 is twice
CC lower with Leu-192 than with Pro-192. {ECO:0000269|PubMed:17416745}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR6
CC subfamily. {ECO:0000305}.
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DR EMBL; AB248749; BAF37829.1; -; mRNA.
DR EMBL; AP009124; BAF45332.1; -; Genomic_DNA.
DR RefSeq; NP_001090968.1; NM_001097499.1.
DR AlphaFoldDB; A0P8Z4; -.
DR SMR; A0P8Z4; -.
DR BioGRID; 1151537; 2.
DR STRING; 9823.ENSSSCP00000005986; -.
DR PaxDb; A0P8Z4; -.
DR PRIDE; A0P8Z4; -.
DR GeneID; 100038028; -.
DR KEGG; ssc:100038028; -.
DR CTD; 2649; -.
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; A0P8Z4; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Nucleus; Receptor; Reference proteome; Spermatogenesis; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..479
FT /note="Nuclear receptor subfamily 6 group A member 1"
FT /id="PRO_0000311223"
FT DOMAIN 248..479
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 57..132
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 60..80
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 96..120
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..252
FT /note="Sufficient for interaction with UIMC1"
FT /evidence="ECO:0000250"
FT COMPBIAS 173..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 192
FT /note="P -> L (may be associated with an increase in number
FT of vertebrae in European domestic breds)"
FT /evidence="ECO:0000269|PubMed:17416745"
SQ SEQUENCE 479 AA; 54350 MW; 00CD8ED7F8F40D4A CRC64;
MERDERPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPSTISV PDDRAEQRTC
LICGDRATGL HYGIISCEGC KGFFKRSICN KRVYRCSRDK NCVMSRKQRN RCQYCRLLKC
LQMGMNRKAI REDGMPGGRN KSIGPVQISE EEIERIMSGQ EFEEEANHWS NHGDSDHSSP
GNRASESNQP SPGSTLSSRS VELNGFMAFR DQYMGMSVPP HYQYIPHLFS YSAHSPLLPP
QARSLDPQSY SLIHQLVSAE DLEPLGTPML IEDGYAVTQA ELFALLCRLA DELLFRQIAW
IKKLPFFCEL SIKDYTCLLS STWQELILLS SLTVYSKQIF GELADVTAKY SPSDEELHRF
SDEGMEVIER LIYLYHKFHQ LKVSNEEYAC MKAINFLNQD IRGLTSASQL EQLNKRYWYI
CQDFTEYKYT HQPNRFPDLM MCLPEIRYIA GKMVNVPLEQ LPLLFKVVLH SCKTSVGKE
