NRAC_HUMAN
ID NRAC_HUMAN Reviewed; 160 AA.
AC Q8N912;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Nutritionally-regulated adipose and cardiac enriched protein homolog;
GN Name=NRAC; Synonyms=C14orf180, C14orf77;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N912; Q92482: AQP3; NbExp=3; IntAct=EBI-12051377, EBI-2808854;
CC Q8N912; Q13520: AQP6; NbExp=3; IntAct=EBI-12051377, EBI-13059134;
CC Q8N912; Q8WWH4: ASZ1; NbExp=3; IntAct=EBI-12051377, EBI-12239061;
CC Q8N912; Q13323: BIK; NbExp=3; IntAct=EBI-12051377, EBI-700794;
CC Q8N912; P04233-2: CD74; NbExp=4; IntAct=EBI-12051377, EBI-12222807;
CC Q8N912; P11912: CD79A; NbExp=3; IntAct=EBI-12051377, EBI-7797864;
CC Q8N912; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-12051377, EBI-1045797;
CC Q8N912; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-12051377, EBI-11989440;
CC Q8N912; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-12051377, EBI-18013275;
CC Q8N912; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-12051377, EBI-2680384;
CC Q8N912; O00559: EBAG9; NbExp=3; IntAct=EBI-12051377, EBI-8787095;
CC Q8N912; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12051377, EBI-781551;
CC Q8N912; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-12051377, EBI-18636064;
CC Q8N912; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12051377, EBI-18304435;
CC Q8N912; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-12051377, EBI-13345167;
CC Q8N912; Q9NZD1: GPRC5D; NbExp=3; IntAct=EBI-12051377, EBI-13067820;
CC Q8N912; Q8TED1: GPX8; NbExp=3; IntAct=EBI-12051377, EBI-11721746;
CC Q8N912; O00219-2: HAS3; NbExp=3; IntAct=EBI-12051377, EBI-17186025;
CC Q8N912; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-12051377, EBI-749265;
CC Q8N912; P48051: KCNJ6; NbExp=3; IntAct=EBI-12051377, EBI-12017638;
CC Q8N912; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-12051377, EBI-2820517;
CC Q8N912; Q9H400: LIME1; NbExp=3; IntAct=EBI-12051377, EBI-2830566;
CC Q8N912; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-12051377, EBI-11956541;
CC Q8N912; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-12051377, EBI-373355;
CC Q8N912; O14880: MGST3; NbExp=3; IntAct=EBI-12051377, EBI-724754;
CC Q8N912; P15941-11: MUC1; NbExp=3; IntAct=EBI-12051377, EBI-17263240;
CC Q8N912; Q68D85: NCR3LG1; NbExp=3; IntAct=EBI-12051377, EBI-14061804;
CC Q8N912; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-12051377, EBI-716063;
CC Q8N912; P62140: PPP1CB; NbExp=3; IntAct=EBI-12051377, EBI-352350;
CC Q8N912; P36873: PPP1CC; NbExp=3; IntAct=EBI-12051377, EBI-356283;
CC Q8N912; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-12051377, EBI-7545592;
CC Q8N912; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-12051377, EBI-3920694;
CC Q8N912; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-12051377, EBI-17295964;
CC Q8N912; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-12051377, EBI-19027521;
CC Q8N912; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-12051377, EBI-6268651;
CC Q8N912; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-12051377, EBI-6448756;
CC Q8N912; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-12051377, EBI-2821497;
CC Q8N912; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12051377, EBI-8638294;
CC Q8N912; Q9NRX6: TMEM167B; NbExp=3; IntAct=EBI-12051377, EBI-17684533;
CC Q8N912; Q6UWW9: TMEM207; NbExp=3; IntAct=EBI-12051377, EBI-13301303;
CC Q8N912; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-12051377, EBI-726044;
CC Q8N912; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-12051377, EBI-11742770;
CC Q8N912; Q9H7M9: VSIR; NbExp=3; IntAct=EBI-12051377, EBI-744988;
CC Q8N912; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-12051377, EBI-12837904;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}.
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DR EMBL; AK095913; BAC04645.1; -; mRNA.
DR EMBL; BX161457; CAD61919.1; -; mRNA.
DR EMBL; CH471061; EAW81864.1; -; Genomic_DNA.
DR EMBL; BC041103; AAH41103.1; -; mRNA.
DR CCDS; CCDS32166.1; -.
DR RefSeq; NP_001008404.1; NM_001008404.2.
DR RefSeq; NP_001273328.1; NM_001286399.1.
DR RefSeq; NP_001273329.1; NM_001286400.1.
DR AlphaFoldDB; Q8N912; -.
DR SMR; Q8N912; -.
DR BioGRID; 134560; 45.
DR IntAct; Q8N912; 44.
DR BioMuta; C14orf180; -.
DR jPOST; Q8N912; -.
DR MassIVE; Q8N912; -.
DR PaxDb; Q8N912; -.
DR PeptideAtlas; Q8N912; -.
DR PRIDE; Q8N912; -.
DR ProteomicsDB; 72484; -.
DR Antibodypedia; 28178; 67 antibodies from 14 providers.
DR DNASU; 400258; -.
DR Ensembl; ENST00000410013.1; ENSP00000386487.1; ENSG00000184601.11.
DR Ensembl; ENST00000557649.6; ENSP00000452502.1; ENSG00000184601.11.
DR Ensembl; ENST00000618752.2; ENSP00000480567.1; ENSG00000274126.4.
DR Ensembl; ENST00000630349.2; ENSP00000487058.1; ENSG00000274126.4.
DR GeneID; 400258; -.
DR KEGG; hsa:400258; -.
DR MANE-Select; ENST00000557649.6; ENSP00000452502.1; NM_001008404.3; NP_001008404.1.
DR UCSC; uc001yow.3; human.
DR CTD; 400258; -.
DR DisGeNET; 400258; -.
DR GeneCards; C14orf180; -.
DR HGNC; HGNC:33795; C14orf180.
DR HPA; ENSG00000184601; Group enriched (adipose tissue, breast, heart muscle).
DR MIM; 619392; gene.
DR neXtProt; NX_Q8N912; -.
DR OpenTargets; ENSG00000184601; -.
DR PharmGKB; PA162378139; -.
DR VEuPathDB; HostDB:ENSG00000184601; -.
DR eggNOG; ENOG502S3R9; Eukaryota.
DR GeneTree; ENSGT00390000001214; -.
DR HOGENOM; CLU_139836_0_0_1; -.
DR InParanoid; Q8N912; -.
DR OMA; HAALTCW; -.
DR OrthoDB; 1483884at2759; -.
DR PhylomeDB; Q8N912; -.
DR TreeFam; TF336371; -.
DR PathwayCommons; Q8N912; -.
DR SignaLink; Q8N912; -.
DR BioGRID-ORCS; 400258; 10 hits in 1049 CRISPR screens.
DR GenomeRNAi; 400258; -.
DR Pharos; Q8N912; Tbio.
DR PRO; PR:Q8N912; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8N912; protein.
DR Bgee; ENSG00000184601; Expressed in apex of heart and 84 other tissues.
DR ExpressionAtlas; Q8N912; baseline and differential.
DR Genevisible; Q8N912; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR028114; DUF4658.
DR PANTHER; PTHR36868; PTHR36868; 1.
DR Pfam; PF15555; DUF4658; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..160
FT /note="Nutritionally-regulated adipose and cardiac enriched
FT protein homolog"
FT /id="PRO_0000326052"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 160 AA; 18051 MW; CFDFAF575988E9E1 CRC64;
MRTAAGAVSP DSRPETRRQT RKNEEAAWGP RVCRAEREDN RKCPPSILKR SRPEHHRPEA
KPQRTSRRVW FREPPAVTVH YIADKNATAT VRVPGRPRPH GGSLLLQLCV CVLLVLALGL
YCGRAKPVAT ALEDLRARLL GLVLHLRHVA LTCWRGLLRL
