NRAC_MOUSE
ID NRAC_MOUSE Reviewed; 165 AA.
AC Q8BNX7; Q8R0Q1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Nutritionally-regulated adipose and cardiac-enriched protein;
GN Name=Nrac;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Aorta, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary gland, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=23029450; DOI=10.1371/journal.pone.0046254;
RA Zhang R., Yao F., Gao F., Abou-Samra A.B.;
RT "Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.";
RL PLoS ONE 7:E46254-E46254(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23029450};
CC Single-pass membrane protein {ECO:0000269|PubMed:23029450}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in white adipose tissue (at
CC protein level) and brown adipose tissue. Also detected in heart.
CC {ECO:0000269|PubMed:23029450}.
CC -!- INDUCTION: Highly up-regulated during 3T3-L1 cell differentiation into
CC adipocytes. In vivo, down-regulated by fasting in both white and brown
CC adipose tissues. Reduced in white adipose tissue in obese animals.
CC {ECO:0000269|PubMed:23029450}.
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DR EMBL; AK079947; BAC37789.1; -; mRNA.
DR EMBL; AK163065; BAE37179.1; -; mRNA.
DR EMBL; BC026527; AAH26527.1; -; mRNA.
DR EMBL; BC096642; AAH96642.1; -; mRNA.
DR CCDS; CCDS49188.1; -.
DR RefSeq; NP_796013.1; NM_177039.4.
DR RefSeq; XP_006516043.1; XM_006515980.3.
DR RefSeq; XP_006516044.1; XM_006515981.3.
DR AlphaFoldDB; Q8BNX7; -.
DR SMR; Q8BNX7; -.
DR STRING; 10090.ENSMUSP00000056220; -.
DR PaxDb; Q8BNX7; -.
DR PRIDE; Q8BNX7; -.
DR GeneID; 319942; -.
DR KEGG; mmu:319942; -.
DR UCSC; uc007peq.2; mouse.
DR MGI; MGI:2443020; A530016L24Rik.
DR eggNOG; ENOG502S3R9; Eukaryota.
DR InParanoid; Q8BNX7; -.
DR OrthoDB; 1444418at2759; -.
DR PhylomeDB; Q8BNX7; -.
DR TreeFam; TF336371; -.
DR BioGRID-ORCS; 319942; 1 hit in 72 CRISPR screens.
DR ChiTaRS; A530016L24Rik; mouse.
DR PRO; PR:Q8BNX7; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8BNX7; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR InterPro; IPR028114; DUF4658.
DR PANTHER; PTHR36868; PTHR36868; 1.
DR Pfam; PF15555; DUF4658; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..165
FT /note="Nutritionally-regulated adipose and cardiac-enriched
FT protein"
FT /id="PRO_0000326053"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 17
FT /note="R -> C (in Ref. 1; BAC37789/BAE37179)"
FT /evidence="ECO:0000305"
FT CONFLICT 28
FT /note="W -> R (in Ref. 1; BAC37789/BAE37179)"
FT /evidence="ECO:0000305"
FT CONFLICT 40
FT /note="D -> N (in Ref. 1; BAC37789/BAE37179)"
FT /evidence="ECO:0000305"
FT CONFLICT 110
FT /note="C -> R (in Ref. 1; BAC37789/BAE37179)"
FT /evidence="ECO:0000305"
FT CONFLICT 158
FT /note="R -> C (in Ref. 1; BAC37789/BAE37179)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 165 AA; 18347 MW; 62E60875BB0A8D97 CRC64;
MRSAARVSRS NSHPRTRHPT RENEGTTWGS QPSRTERDGD RKCPPSILRP RRQECGCHGG
EPQKTSRHVR FREPLEVAVH YIARKDTTAA IKVPSRPASH GGSPLQPASC SGSLFLWLTL
CALLGVVLVL YCGQAKRVTA ALEDLLAQLL ALILRLWRVV LACWH
