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NRAM1_BOVIN
ID   NRAM1_BOVIN             Reviewed;         548 AA.
AC   Q27981;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Natural resistance-associated macrophage protein 1;
DE            Short=NRAMP 1;
DE   AltName: Full=Solute carrier family 11 member 1;
GN   Name=SLC11A1; Synonyms=NRAMP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8908514; DOI=10.1101/gr.6.10.956;
RA   Feng J., Li Y., Hashad M., Schurr E., Gros P., Adams L.G., Templeton J.W.;
RT   "Bovine natural resistance associated macrophage protein 1 (Nramp1) gene.";
RL   Genome Res. 6:956-964(1996).
CC   -!- FUNCTION: Divalent transition metal (iron and manganese) transporter
CC       involved in iron metabolism and host resistance to certain pathogens.
CC       Macrophage-specific membrane transport function. Controls natural
CC       resistance to infection with intracellular parasites. Pathogen
CC       resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of
CC       both prokaryotic and eukaryotic catalases and superoxide dismutases,
CC       not only to protect the macrophage against its own generation of
CC       reactive oxygen species, but to deny the cations to the pathogen for
CC       synthesis of its protective enzymes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000305}.
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DR   EMBL; U12862; AAA82582.1; -; mRNA.
DR   RefSeq; NP_777077.1; NM_174652.2.
DR   AlphaFoldDB; Q27981; -.
DR   SMR; Q27981; -.
DR   STRING; 9913.ENSBTAP00000020627; -.
DR   PaxDb; Q27981; -.
DR   GeneID; 282470; -.
DR   KEGG; bta:282470; -.
DR   CTD; 6556; -.
DR   eggNOG; KOG1291; Eukaryota.
DR   InParanoid; Q27981; -.
DR   OrthoDB; 666470at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0051139; F:metal ion:proton antiporter activity; IBA:GO_Central.
DR   GO; GO:0006876; P:cellular cadmium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IBA:GO_Central.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
DR   HAMAP; MF_00221; NRAMP; 1.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706; PTHR11706; 1.
DR   Pfam; PF01566; Nramp; 1.
DR   PRINTS; PR00447; NATRESASSCMP.
DR   TIGRFAMs; TIGR01197; nramp; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion transport; Iron; Iron transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..548
FT                   /note="Natural resistance-associated macrophage protein 1"
FT                   /id="PRO_0000212584"
FT   TOPO_DOM        1..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..82
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..164
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        185..193
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        215..237
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..284
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        305..346
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        367..397
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        398..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        416..426
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        448..463
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        464..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        486..493
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        494..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        514..548
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        335
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   548 AA;  59568 MW;  FAC8EB2B2B878118 CRC64;
     MSGDTGPPKQ GGTRYGSISS PPSPEPQQAP PGGTYLSEKI PIPDTESGTF SLRKLWAFTG
     PGFLMSIAFL DPGNIESDLQ AGAVAGFKLL WVLLWATVLG LLCQRLAARL GVVTGKDLGE
     VCHLYYPKVP RILLWLTIEL AIVGSDMQEV IGTAIAFSLL SAGRIPLWGG VLITVVDTFF
     FLFLDNYGLR KLEAFFGFLI TIMALTFGYE YVVAQPAQGA LLQGLFLPSC PGCGQPELLQ
     AVGIIGAIIM PHNIYLHSSL VKSREVDRSR RADIREANMY FLIEATIALS VSFLINLFVM
     AVFGQAFYKQ TNQAAFNICA DSSLHDYAPI FPRNNLTVAV DIYQGGVILG CLFGPPALYI
     WAVGLLAAGQ SSTMTGTYAG QFVMEGFLKL RWSRFARVLL TRSCAILPTV LLAVFRDLRD
     LSGLNDLLNV LQSLLLPFAV LPILTFTSMP ALMQEFANGL VSKVITSSIM VLVCAVNLYF
     VISYLPSLPH PAYFSLVALL AAAYLGLTTY LVWTCLITQG ATLLAHSSHQ RFLYGLPEED
     QEKGRTSG
 
 
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