NRAM1_CHICK
ID NRAM1_CHICK Reviewed; 555 AA.
AC P51027;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Natural resistance-associated macrophage protein 1;
DE Short=NRAMP 1;
DE AltName: Full=Solute carrier family 11 member 1;
GN Name=SLC11A1; Synonyms=NRAMP1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=White leghorn; TISSUE=Spleen;
RX PubMed=8634139; DOI=10.1089/dna.1996.15.113;
RA Hu J., Bumstead N., Skamene E., Gros P., Malo D.;
RT "Structural organization, sequence, and expression of the chicken NRAMP1
RT gene encoding the natural resistance-associated macrophage protein 1.";
RL DNA Cell Biol. 15:113-123(1996).
CC -!- FUNCTION: Divalent transition metal (iron and manganese) transporter
CC involved in iron metabolism and host resistance to certain pathogens.
CC Macrophage-specific membrane transport function. Controls natural
CC resistance to infection with intracellular parasites. Pathogen
CC resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of
CC both prokaryotic and eukaryotic catalases and superoxide dismutases,
CC not only to protect the macrophage against its own generation of
CC reactive oxygen species, but to deny the cations to the pathogen for
CC synthesis of its protective enzymes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Macrophages; spleen and thymus and at lower level
CC in liver and lung.
CC -!- INDUCTION: In response to lymphokine or bacterial products.
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000305}.
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DR EMBL; U40598; AAC59756.1; -; mRNA.
DR EMBL; S82465; AAD14396.1; -; Genomic_DNA.
DR RefSeq; NP_990295.1; NM_204964.1.
DR AlphaFoldDB; P51027; -.
DR SMR; P51027; -.
DR STRING; 9031.ENSGALP00000018625; -.
DR PaxDb; P51027; -.
DR Ensembl; ENSGALT00000018648; ENSGALP00000018625; ENSGALG00000011434.
DR GeneID; 395811; -.
DR KEGG; gga:395811; -.
DR CTD; 6556; -.
DR VEuPathDB; HostDB:geneid_395811; -.
DR eggNOG; KOG1291; Eukaryota.
DR GeneTree; ENSGT00940000160799; -.
DR HOGENOM; CLU_020088_5_2_1; -.
DR InParanoid; P51027; -.
DR OMA; SPKWLRY; -.
DR OrthoDB; 666470at2759; -.
DR PhylomeDB; P51027; -.
DR PRO; PR:P51027; -.
DR Proteomes; UP000000539; Chromosome 7.
DR Bgee; ENSGALG00000011434; Expressed in spleen and 13 other tissues.
DR ExpressionAtlas; P51027; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IDA:AgBase.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:AgBase.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IGI:AgBase.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0051139; F:metal ion:proton antiporter activity; IGI:BHF-UCL.
DR GO; GO:0046915; F:transition metal ion transmembrane transporter activity; IGI:BHF-UCL.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IGI:AgBase.
DR GO; GO:0070574; P:cadmium ion transmembrane transport; IGI:AgBase.
DR GO; GO:0006876; P:cellular cadmium ion homeostasis; IGI:BHF-UCL.
DR GO; GO:0006879; P:cellular iron ion homeostasis; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; ISS:BHF-UCL.
DR GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; IGI:AgBase.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Iron; Iron transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..555
FT /note="Natural resistance-associated macrophage protein 1"
FT /id="PRO_0000212593"
FT TOPO_DOM 1..63
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..172
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..245
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..354
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..434
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 456..471
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 494..501
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 502..521
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 522..555
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 329
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 555 AA; 60967 MW; AC1D25AF1F563C0A CRC64;
MSGSGPAMAS LEPGLAGSLN RGQTDASNVP VPPHHPVPHA QTYLDELISI PKGSTPGFSF
RKLWAFTGPG FLMSIAYLDP GNVESDLQCG AVAGFKLLWV LLWATVLGLL CQRLAIRLGV
VTGKDLAEIC YLYYPRVPRV LLWLMMEIAI IGSDMQEVIG TAIAFSLLSA GRIPLWGGVL
ITITDTLFFL FLDKYGLRKL EAFFGFLITI MALTFGYEYV MVRPAQTEVL KGIFLPYCPG
CGREELLQAV GIVGAIIMPH NIFLHSSLVK TRAIDRSKKE EVKEANMYFL TESCLALFVS
FLINLFVMAV FGEAFYHQRN EDVHNKCVNS SVSRYASIFP INNETVSVDI YQGGVILGCY
FGAAALYIWA VGILAAGQSS TMTGTYAGQF VMEGFLQLRW SRFTRVLFTR SLAILPTLFV
AAFRDVSQLT GMNDLLNVLQ SILLPFAVLP VLTFTSLRPL MHDFANGLLG QVLMSLITGL
VCAINVYFVV DFLPTLRGLG YLIPLGLLLV AYVAFVTYLL WTCSIAHGAR FLARGRYNRF
SFDVTADVPG LAGPH
