NRAM1_HUMAN
ID NRAM1_HUMAN Reviewed; 550 AA.
AC P49279; C0H5Y3;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Natural resistance-associated macrophage protein 1;
DE Short=NRAMP 1;
DE AltName: Full=Solute carrier family 11 member 1;
GN Name=SLC11A1; Synonyms=LSH, NRAMP, NRAMP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RC TISSUE=Spleen;
RX PubMed=7964458; DOI=10.1084/jem.180.5.1741;
RA Cellier M., Govoni G., Vidal S., Kwan T., Groulx N., Liu J., Sanchez F.,
RA Skamene E., Schurr E., Gros P.;
RT "Human natural resistance-associated macrophage protein: cDNA cloning,
RT chromosomal mapping, genomic organization, and tissue-specific
RT expression.";
RL J. Exp. Med. 180:1741-1752(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Spleen;
RX PubMed=8537108; DOI=10.1016/0165-2478(95)00070-l;
RA Kishi F., Nobumoto M.;
RT "Identification of natural resistance-associated macrophage protein in
RT peripheral blood lymphocytes.";
RL Immunol. Lett. 47:93-96(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10967134; DOI=10.1007/s003350010151;
RA Marquet S., Lepage P., Hudson T.J., Musser J.M., Schurr E.;
RT "Complete nucleotide sequence and genomic structure of the human NRAMP1
RT gene region on chromosome region 2q35.";
RL Mamm. Genome 11:755-762(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 68-550 (ISOFORM 1).
RX PubMed=7980580; DOI=10.1006/bbrc.1994.2572;
RA Kishi F.;
RT "Isolation and characterization of human Nramp cDNA.";
RL Biochem. Biophys. Res. Commun. 204:1074-1080(1994).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8529098; DOI=10.1007/bf03401567;
RA Blackwell J.M., Barton C.H., White J.K., Searle S., Baker A.-M.,
RA Williams H., Shaw M.-A.;
RT "Genomic organization and sequence of the human NRAMP gene: identification
RT and mapping of a promoter region polymorphism.";
RL Mol. Med. 1:194-205(1995).
RN [9]
RP VARIANTS VAL-318 AND ASN-543.
RX PubMed=7717395;
RA Liu J., Fujiwara T.M., Buu N.T., Sanchez F.O., Cellier M., Paradis A.J.,
RA Frappier D., Skamene E., Gros P., Morgan K., Schurr E.;
RT "Identification of polymorphisms and sequence variants in the human
RT homologue of the mouse natural resistance-associated macrophage protein
RT gene.";
RL Am. J. Hum. Genet. 56:845-853(1995).
RN [10]
RP INVOLVEMENT IN MYCOBACTERIUM TUBERCULOSIS SUSCEPTIBILITY.
RX PubMed=16103355; DOI=10.1073/pnas.0503368102;
RA Malik S., Abel L., Tooker H., Poon A., Simkin L., Girard M., Adams G.J.,
RA Starke J.R., Smith K.C., Graviss E.A., Musser J.M., Schurr E.;
RT "Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis
RT disease.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12183-12188(2005).
RN [11]
RP ASSOCIATION OF VARIANT ASN-543 WITH SUSCEPTIBILITY TO INFECTION WITH
RP MYCOBACTERIUM ULCERANS.
RX PubMed=16395392; DOI=10.1038/sj.gene.6364281;
RA Stienstra Y., van der Werf T.S., Oosterom E., Nolte I.M.,
RA van der Graaf W.T.A., Etuaful S., Raghunathan P.L., Whitney E.A.S.,
RA Ampadu E.O., Asamoa K., Klutse E.Y., te Meerman G.J., Tappero J.W.,
RA Ashford D.A., van der Steege G.;
RT "Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1)
RT D543N polymorphism.";
RL Genes Immun. 7:185-189(2006).
CC -!- FUNCTION: Divalent transition metal (iron and manganese) transporter
CC involved in iron metabolism and host resistance to certain pathogens.
CC Macrophage-specific membrane transport function. Controls natural
CC resistance to infection with intracellular parasites. Pathogen
CC resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of
CC both prokaryotic and eukaryotic catalases and superoxide dismutases,
CC not only to protect the macrophage against its own generation of
CC reactive oxygen species, but to deny the cations to the pathogen for
CC synthesis of its protective enzymes.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P49279-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P49279-2; Sequence=VSP_047875, VSP_047876;
CC -!- TISSUE SPECIFICITY: Macrophages; peripheral blood leukocytes, lung,
CC spleen and liver.
CC -!- INDUCTION: In response to lymphokine or bacterial products.
CC -!- POLYMORPHISM: Genetic variation in SLC11A1 is associated with
CC susceptibility to infection with Mycobacterium ulcerans [MIM:610446].
CC -!- POLYMORPHISM: Genetic variations in SLC11A1 determine Mycobacterium
CC tuberculosis susceptibility [MIM:607948].
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000305}.
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DR EMBL; L32185; AAA57521.1; -; mRNA.
DR EMBL; L38593; AAA57557.1; -; Genomic_DNA.
DR EMBL; L38592; AAA57557.1; JOINED; Genomic_DNA.
DR EMBL; AF229163; AAG15405.1; -; Genomic_DNA.
DR EMBL; AC021016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471063; EAW70611.1; -; Genomic_DNA.
DR EMBL; BC071165; AAH71165.1; -; mRNA.
DR EMBL; D50402; BAA08907.1; -; mRNA.
DR EMBL; D50403; BAA08908.1; -; mRNA.
DR EMBL; D38171; BAA07370.1; -; mRNA.
DR EMBL; X82015; CAA57541.1; -; Genomic_DNA.
DR CCDS; CCDS2415.1; -. [P49279-1]
DR PIR; I55679; I55679.
DR PIR; JC4095; JC4095.
DR RefSeq; NP_000569.3; NM_000578.3. [P49279-1]
DR RefSeq; XP_005246850.1; XM_005246793.3.
DR RefSeq; XP_005246851.1; XM_005246794.3. [P49279-2]
DR RefSeq; XP_006712772.1; XM_006712709.3. [P49279-2]
DR RefSeq; XP_006712773.1; XM_006712710.3. [P49279-2]
DR RefSeq; XP_016860255.1; XM_017004766.1.
DR AlphaFoldDB; P49279; -.
DR SMR; P49279; -.
DR STRING; 9606.ENSP00000233202; -.
DR BindingDB; P49279; -.
DR ChEMBL; CHEMBL2052040; -.
DR TCDB; 2.A.55.2.3; the metal ion (mn(2+)-iron) transporter (nramp) family.
DR GlyGen; P49279; 2 sites.
DR iPTMnet; P49279; -.
DR PhosphoSitePlus; P49279; -.
DR BioMuta; SLC11A1; -.
DR DMDM; 1352521; -.
DR MassIVE; P49279; -.
DR PaxDb; P49279; -.
DR PeptideAtlas; P49279; -.
DR PRIDE; P49279; -.
DR ProteomicsDB; 55978; -. [P49279-1]
DR ProteomicsDB; 7572; -.
DR Antibodypedia; 3997; 193 antibodies from 27 providers.
DR DNASU; 6556; -.
DR Ensembl; ENST00000233202.11; ENSP00000233202.6; ENSG00000018280.17. [P49279-1]
DR GeneID; 6556; -.
DR KEGG; hsa:6556; -.
DR MANE-Select; ENST00000233202.11; ENSP00000233202.6; NM_000578.4; NP_000569.3.
DR UCSC; uc002vhv.3; human. [P49279-1]
DR CTD; 6556; -.
DR DisGeNET; 6556; -.
DR GeneCards; SLC11A1; -.
DR HGNC; HGNC:10907; SLC11A1.
DR HPA; ENSG00000018280; Group enriched (lung, lymphoid tissue).
DR MalaCards; SLC11A1; -.
DR MIM; 600266; gene.
DR MIM; 607948; phenotype.
DR MIM; 610446; phenotype.
DR neXtProt; NX_P49279; -.
DR OpenTargets; ENSG00000018280; -.
DR Orphanet; 586; Cystic fibrosis.
DR Orphanet; 3389; Tuberculosis.
DR PharmGKB; PA319; -.
DR VEuPathDB; HostDB:ENSG00000018280; -.
DR eggNOG; KOG1291; Eukaryota.
DR GeneTree; ENSGT00940000160799; -.
DR HOGENOM; CLU_020088_5_2_1; -.
DR InParanoid; P49279; -.
DR OMA; SPKWLRY; -.
DR PhylomeDB; P49279; -.
DR TreeFam; TF315185; -.
DR PathwayCommons; P49279; -.
DR Reactome; R-HSA-1222556; ROS and RNS production in phagocytes.
DR Reactome; R-HSA-425410; Metal ion SLC transporters.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR Reactome; R-HSA-6803544; Ion influx/efflux at host-pathogen interface.
DR SignaLink; P49279; -.
DR SIGNOR; P49279; -.
DR BioGRID-ORCS; 6556; 10 hits in 1067 CRISPR screens.
DR ChiTaRS; SLC11A1; human.
DR GeneWiki; SLC11A1; -.
DR GenomeRNAi; 6556; -.
DR Pharos; P49279; Tbio.
DR PRO; PR:P49279; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P49279; protein.
DR Bgee; ENSG00000018280; Expressed in right lung and 134 other tissues.
DR ExpressionAtlas; P49279; baseline and differential.
DR Genevisible; P49279; HS.
DR GO; GO:0101003; C:ficolin-1-rich granule membrane; TAS:Reactome.
DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB.
DR GO; GO:0005770; C:late endosome; ISS:BHF-UCL.
DR GO; GO:0031902; C:late endosome membrane; TAS:Reactome.
DR GO; GO:0005764; C:lysosome; ISS:BHF-UCL.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IDA:BHF-UCL.
DR GO; GO:0005886; C:plasma membrane; IMP:BHF-UCL.
DR GO; GO:0070821; C:tertiary granule membrane; IDA:BHF-UCL.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; ISS:BHF-UCL.
DR GO; GO:0051139; F:metal ion:proton antiporter activity; IGI:BHF-UCL.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0046915; F:transition metal ion transmembrane transporter activity; IGI:BHF-UCL.
DR GO; GO:0032147; P:activation of protein kinase activity; ISS:BHF-UCL.
DR GO; GO:0048002; P:antigen processing and presentation of peptide antigen; ISS:BHF-UCL.
DR GO; GO:0019730; P:antimicrobial humoral response; TAS:Reactome.
DR GO; GO:0070574; P:cadmium ion transmembrane transport; IGI:BHF-UCL.
DR GO; GO:0045454; P:cell redox homeostasis; TAS:Reactome.
DR GO; GO:0006876; P:cellular cadmium ion homeostasis; IGI:BHF-UCL.
DR GO; GO:0006879; P:cellular iron ion homeostasis; IMP:BHF-UCL.
DR GO; GO:0042742; P:defense response to bacterium; ISS:BHF-UCL.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:BHF-UCL.
DR GO; GO:0042832; P:defense response to protozoan; ISS:BHF-UCL.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; ISS:BHF-UCL.
DR GO; GO:0055072; P:iron ion homeostasis; ISS:BHF-UCL.
DR GO; GO:0006826; P:iron ion transport; IMP:BHF-UCL.
DR GO; GO:1903826; P:L-arginine transmembrane transport; IEA:Ensembl.
DR GO; GO:0042116; P:macrophage activation; ISS:BHF-UCL.
DR GO; GO:0006828; P:manganese ion transport; ISS:BHF-UCL.
DR GO; GO:0030001; P:metal ion transport; ISS:BHF-UCL.
DR GO; GO:0045342; P:MHC class II biosynthetic process; ISS:BHF-UCL.
DR GO; GO:0048255; P:mRNA stabilization; ISS:BHF-UCL.
DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; ISS:BHF-UCL.
DR GO; GO:0001818; P:negative regulation of cytokine production; ISS:BHF-UCL.
DR GO; GO:0015707; P:nitrite transport; ISS:BHF-UCL.
DR GO; GO:0006909; P:phagocytosis; ISS:BHF-UCL.
DR GO; GO:0001819; P:positive regulation of cytokine production; ISS:BHF-UCL.
DR GO; GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; ISS:BHF-UCL.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:BHF-UCL.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; ISS:ARUK-UCL.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:BHF-UCL.
DR GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; ISS:BHF-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:BHF-UCL.
DR GO; GO:0045730; P:respiratory burst; ISS:BHF-UCL.
DR GO; GO:0009617; P:response to bacterium; IDA:UniProtKB.
DR GO; GO:0034341; P:response to interferon-gamma; ISS:BHF-UCL.
DR GO; GO:0032496; P:response to lipopolysaccharide; ISS:BHF-UCL.
DR GO; GO:0002309; P:T cell proliferation involved in immune response; ISS:BHF-UCL.
DR GO; GO:0007035; P:vacuolar acidification; ISS:BHF-UCL.
DR GO; GO:0042060; P:wound healing; ISS:BHF-UCL.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Ion transport; Iron; Iron transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..550
FT /note="Natural resistance-associated macrophage protein 1"
FT /id="PRO_0000212588"
FT TOPO_DOM 1..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..85
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..196
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..240
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..349
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 370..400
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 419..429
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..466
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..488
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 489..496
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 497..516
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 517..550
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 338
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..13
FT /note="MTGDKGPQRLSGS -> MVRCQLTATSTSQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_047875"
FT VAR_SEQ 14..131
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_047876"
FT VARIANT 30
FT /note="Q -> R (in dbSNP:rs751872662)"
FT /id="VAR_004629"
FT VARIANT 318
FT /note="A -> V (in dbSNP:rs201565523)"
FT /evidence="ECO:0000269|PubMed:7717395"
FT /id="VAR_004630"
FT VARIANT 543
FT /note="D -> N (associated with susceptibility to infection
FT with Mycobacterium ulcerans; dbSNP:rs17235409)"
FT /evidence="ECO:0000269|PubMed:7717395"
FT /id="VAR_004631"
FT CONFLICT 54
FT /note="S -> R (in Ref. 8; CAA57541)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="A -> L (in Ref. 8)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="A -> P (in Ref. 8)"
FT /evidence="ECO:0000305"
FT CONFLICT 275
FT /note="A -> V (in Ref. 8; CAA57541)"
FT /evidence="ECO:0000305"
FT CONFLICT 305
FT /note="V -> A (in Ref. 8; CAA57541)"
FT /evidence="ECO:0000305"
FT CONFLICT 315
FT /note="N -> K (in Ref. 8; CAA57541)"
FT /evidence="ECO:0000305"
FT CONFLICT 397
FT /note="R -> S (in Ref. 8; CAA57541)"
FT /evidence="ECO:0000305"
FT CONFLICT 441
FT /note="F -> V (in Ref. 8; CAA57541)"
FT /evidence="ECO:0000305"
FT CONFLICT 478
FT /note="A -> T (in Ref. 8; CAA57541)"
FT /evidence="ECO:0000305"
FT CONFLICT 544
FT /note="Q -> H (in Ref. 8; CAA57541)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 550 AA; 59872 MW; AA670763D52EEECC CRC64;
MTGDKGPQRL SGSSYGSISS PTSPTSPGPQ QAPPRETYLS EKIPIPDTKP GTFSLRKLWA
FTGPGFLMSI AFLDPGNIES DLQAGAVAGF KLLWVLLWAT VLGLLCQRLA ARLGVVTGKD
LGEVCHLYYP KVPRTVLWLT IELAIVGSDM QEVIGTAIAF NLLSAGRIPL WGGVLITIVD
TFFFLFLDNY GLRKLEAFFG LLITIMALTF GYEYVVARPE QGALLRGLFL PSCPGCGHPE
LLQAVGIVGA IIMPHNIYLH SALVKSREID RARRADIREA NMYFLIEATI ALSVSFIINL
FVMAVFGQAF YQKTNQAAFN ICANSSLHDY AKIFPMNNAT VAVDIYQGGV ILGCLFGPAA
LYIWAIGLLA AGQSSTMTGT YAGQFVMEGF LRLRWSRFAR VLLTRSCAIL PTVLVAVFRD
LRDLSGLNDL LNVLQSLLLP FAVLPILTFT SMPTLMQEFA NGLLNKVVTS SIMVLVCAIN
LYFVVSYLPS LPHPAYFGLA ALLAAAYLGL STYLVWTCCL AHGATFLAHS SHHHFLYGLL
EEDQKGETSG
