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NRAM1_ORYSJ
ID   NRAM1_ORYSJ             Reviewed;         518 AA.
AC   Q0D7E4; A0A0P0X4X3; Q1W6C2; Q8GTY9;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Metal transporter Nramp1;
DE            Short=OsNramp1;
GN   Name=NRAMP1; OrderedLocusNames=Os07g0258400, LOC_Os07g15460;
GN   ORFNames=OJ1354_H07.109, OsJ_23752;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Jingdao 21; TISSUE=Root;
RA   Hao X., Huang Q.N., Yin L.-P.;
RT   "Cloning and cellular location in cells of OsNramp1.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   FUNCTION.
RX   PubMed=10769179; DOI=10.1042/bj3470749;
RA   Curie C., Alonso J.M., Le Jean M., Ecker J.R., Briat J.-F.;
RT   "Involvement of NRAMP1 from Arabidopsis thaliana in iron transport.";
RL   Biochem. J. 347:749-755(2000).
CC   -!- FUNCTION: Probable metal transporter that may participate in the
CC       control of iron homeostasis. {ECO:0000269|PubMed:10769179}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NRAMP (TC 2.A.55) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC83021.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DQ431468; ABD85292.1; -; mRNA.
DR   EMBL; AP003755; BAC83021.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008213; BAF21229.1; -; Genomic_DNA.
DR   EMBL; AP014963; BAT00879.1; -; Genomic_DNA.
DR   EMBL; CM000144; EEE66907.1; -; Genomic_DNA.
DR   RefSeq; XP_015647629.1; XM_015792143.1.
DR   AlphaFoldDB; Q0D7E4; -.
DR   SMR; Q0D7E4; -.
DR   STRING; 4530.OS07T0258400-01; -.
DR   PaxDb; Q0D7E4; -.
DR   PRIDE; Q0D7E4; -.
DR   EnsemblPlants; Os07t0258400-01; Os07t0258400-01; Os07g0258400.
DR   EnsemblPlants; Os07t0258400-03; Os07t0258400-03; Os07g0258400.
DR   GeneID; 4342862; -.
DR   Gramene; Os07t0258400-01; Os07t0258400-01; Os07g0258400.
DR   Gramene; Os07t0258400-03; Os07t0258400-03; Os07g0258400.
DR   KEGG; osa:4342862; -.
DR   eggNOG; KOG1291; Eukaryota.
DR   InParanoid; Q0D7E4; -.
DR   OMA; AYIDPGS; -.
DR   OrthoDB; 666470at2759; -.
DR   PlantReactome; R-OSA-9025727; Iron uptake and transport in root vascular system.
DR   PlantReactome; R-OSA-9618218; Arsenic uptake and detoxification.
DR   Proteomes; UP000000763; Chromosome 7.
DR   Proteomes; UP000007752; Chromosome 7.
DR   Proteomes; UP000059680; Chromosome 7.
DR   ExpressionAtlas; Q0D7E4; baseline and differential.
DR   Genevisible; Q0D7E4; OS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IDA:UniProtKB.
DR   GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0034755; P:iron ion transmembrane transport; IDA:UniProtKB.
DR   HAMAP; MF_00221; NRAMP; 1.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706; PTHR11706; 1.
DR   Pfam; PF01566; Nramp; 1.
DR   PRINTS; PR00447; NATRESASSCMP.
DR   TIGRFAMs; TIGR01197; nramp; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..518
FT                   /note="Metal transporter Nramp1"
FT                   /id="PRO_0000405566"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        79
FT                   /note="F -> S (in Ref. 1; ABD85292)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        163
FT                   /note="Q -> R (in Ref. 1; ABD85292)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        411
FT                   /note="M -> I (in Ref. 1; ABD85292)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   518 AA;  55814 MW;  5C1697746ACB62E7 CRC64;
     MGVTKAEAVA GDGGKVVDDI EALADLRKEP AWKRFLSHIG PGFMVCLAYL DPGNMETDLQ
     AGANHKYELL WVILIGLIFA LIIQSLSANL GVVTGRHLAE LCKTEYPVWV KTCLWLLAEL
     AVIASDIPEV IGTGFAFNLL FHIPVWTGVL IAGSSTLLLL GLQRYGVRKL EVVVALLVFV
     MAGCFFVEMS IVKPPVNEVL QGLFIPRLSG PGATGDSIAL LGALVMPHNL FLHSALVLSR
     NTPASAKGMK DVCRFFLFES GIALFVALLV NIAIISVSGT VCNATNLSPE DAVKCSDLTL
     DSSSFLLRNV LGKSSATVYG VALLASGQSS TITGTYAGQY VMQGFLDIKM KQWLRNLMTR
     SIAIVPSLIV SIIGGSSGAG RLIVIASMIL SFELPFALIP LLKFSSSSNK MGENKNSIYI
     VGFSWVLGFV IIGINIYFLS TKLVGWILHN ALPTFANVLI GIVLFPLMLL YVVAVIYLTF
     RKDTVKFVSR RELQAGDDTE KAQVATCVAD EHSKEPPV
 
 
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