NRAM1_ORYSJ
ID NRAM1_ORYSJ Reviewed; 518 AA.
AC Q0D7E4; A0A0P0X4X3; Q1W6C2; Q8GTY9;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Metal transporter Nramp1;
DE Short=OsNramp1;
GN Name=NRAMP1; OrderedLocusNames=Os07g0258400, LOC_Os07g15460;
GN ORFNames=OJ1354_H07.109, OsJ_23752;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Jingdao 21; TISSUE=Root;
RA Hao X., Huang Q.N., Yin L.-P.;
RT "Cloning and cellular location in cells of OsNramp1.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP FUNCTION.
RX PubMed=10769179; DOI=10.1042/bj3470749;
RA Curie C., Alonso J.M., Le Jean M., Ecker J.R., Briat J.-F.;
RT "Involvement of NRAMP1 from Arabidopsis thaliana in iron transport.";
RL Biochem. J. 347:749-755(2000).
CC -!- FUNCTION: Probable metal transporter that may participate in the
CC control of iron homeostasis. {ECO:0000269|PubMed:10769179}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NRAMP (TC 2.A.55) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC83021.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ431468; ABD85292.1; -; mRNA.
DR EMBL; AP003755; BAC83021.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008213; BAF21229.1; -; Genomic_DNA.
DR EMBL; AP014963; BAT00879.1; -; Genomic_DNA.
DR EMBL; CM000144; EEE66907.1; -; Genomic_DNA.
DR RefSeq; XP_015647629.1; XM_015792143.1.
DR AlphaFoldDB; Q0D7E4; -.
DR SMR; Q0D7E4; -.
DR STRING; 4530.OS07T0258400-01; -.
DR PaxDb; Q0D7E4; -.
DR PRIDE; Q0D7E4; -.
DR EnsemblPlants; Os07t0258400-01; Os07t0258400-01; Os07g0258400.
DR EnsemblPlants; Os07t0258400-03; Os07t0258400-03; Os07g0258400.
DR GeneID; 4342862; -.
DR Gramene; Os07t0258400-01; Os07t0258400-01; Os07g0258400.
DR Gramene; Os07t0258400-03; Os07t0258400-03; Os07g0258400.
DR KEGG; osa:4342862; -.
DR eggNOG; KOG1291; Eukaryota.
DR InParanoid; Q0D7E4; -.
DR OMA; AYIDPGS; -.
DR OrthoDB; 666470at2759; -.
DR PlantReactome; R-OSA-9025727; Iron uptake and transport in root vascular system.
DR PlantReactome; R-OSA-9618218; Arsenic uptake and detoxification.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000007752; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR ExpressionAtlas; Q0D7E4; baseline and differential.
DR Genevisible; Q0D7E4; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0034755; P:iron ion transmembrane transport; IDA:UniProtKB.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..518
FT /note="Metal transporter Nramp1"
FT /id="PRO_0000405566"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 79
FT /note="F -> S (in Ref. 1; ABD85292)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="Q -> R (in Ref. 1; ABD85292)"
FT /evidence="ECO:0000305"
FT CONFLICT 411
FT /note="M -> I (in Ref. 1; ABD85292)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 518 AA; 55814 MW; 5C1697746ACB62E7 CRC64;
MGVTKAEAVA GDGGKVVDDI EALADLRKEP AWKRFLSHIG PGFMVCLAYL DPGNMETDLQ
AGANHKYELL WVILIGLIFA LIIQSLSANL GVVTGRHLAE LCKTEYPVWV KTCLWLLAEL
AVIASDIPEV IGTGFAFNLL FHIPVWTGVL IAGSSTLLLL GLQRYGVRKL EVVVALLVFV
MAGCFFVEMS IVKPPVNEVL QGLFIPRLSG PGATGDSIAL LGALVMPHNL FLHSALVLSR
NTPASAKGMK DVCRFFLFES GIALFVALLV NIAIISVSGT VCNATNLSPE DAVKCSDLTL
DSSSFLLRNV LGKSSATVYG VALLASGQSS TITGTYAGQY VMQGFLDIKM KQWLRNLMTR
SIAIVPSLIV SIIGGSSGAG RLIVIASMIL SFELPFALIP LLKFSSSSNK MGENKNSIYI
VGFSWVLGFV IIGINIYFLS TKLVGWILHN ALPTFANVLI GIVLFPLMLL YVVAVIYLTF
RKDTVKFVSR RELQAGDDTE KAQVATCVAD EHSKEPPV