NRAM2_ORYSJ
ID NRAM2_ORYSJ Reviewed; 524 AA.
AC Q10Q65; A0A0P0VUJ2; Q8H059;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Metal transporter Nramp2;
DE Short=OsNramp2;
GN Name=NRAMP2; OrderedLocusNames=Os03g0208500, LOC_Os03g11010;
GN ORFNames=OSJNBa0014O06.13;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Probable metal transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NRAMP (TC 2.A.55) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN77306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC105928; AAN77306.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DP000009; ABF94567.1; -; Genomic_DNA.
DR EMBL; AP008209; BAF11244.1; -; Genomic_DNA.
DR EMBL; AP014959; BAS82886.1; -; Genomic_DNA.
DR EMBL; AK065481; BAG89534.1; -; mRNA.
DR RefSeq; XP_015632573.1; XM_015777087.1.
DR AlphaFoldDB; Q10Q65; -.
DR SMR; Q10Q65; -.
DR STRING; 4530.OS03T0208500-01; -.
DR PaxDb; Q10Q65; -.
DR PRIDE; Q10Q65; -.
DR EnsemblPlants; Os03t0208500-01; Os03t0208500-01; Os03g0208500.
DR GeneID; 4332012; -.
DR Gramene; Os03t0208500-01; Os03t0208500-01; Os03g0208500.
DR KEGG; osa:4332012; -.
DR eggNOG; KOG1291; Eukaryota.
DR HOGENOM; CLU_020088_5_1_1; -.
DR InParanoid; Q10Q65; -.
DR OMA; MRPAFSW; -.
DR OrthoDB; 666470at2759; -.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR ExpressionAtlas; Q10Q65; baseline and differential.
DR Genevisible; Q10Q65; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..524
FT /note="Metal transporter Nramp2"
FT /id="PRO_0000405567"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 34..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 56928 MW; 4831136A0060EADD CRC64;
MASRDLAESL LPVGGGAATA TATATAHDEY DERAYDSDDK VSIAVSDSDS EDGGGGGGDA
MRPAFSWRKL WRFTGPGFLM CIAFLDPGNL EGDLQAGAAA GYQLLWLLLW ATVMGALVQL
LSARLGVATG KHLAELCREE YPPWATRALW AMTELALVGA DIQEVIGSAI AIKILSAGTV
PLWGGVVITA FDCFIFLFLE NYGVRKLEAF FGVLIAVMAV SFAIMFGETK PSGKELLIGL
VVPKLSSRTI KQAVGIVGCI IMPHNVFLHS ALVQSRKIDT NKKSRVQEAV FYYNIESILA
LIVSFFINIC VTTVFAKGFY GSEQADGIGL ENAGQYLQQK YGTAFFPILY IWAIGLLASG
QSSTITGTYA GQFVMGGFLN LRLKKWLRAM ITRSFAIIPT MIVALFFDTE DPTMDILNEA
LNVLQSIQIP FALIPLITLV SKEQVMGSFV VGPITKVISW IVTVFLMLIN GYLILSFYAT
EVRGALVRSS LCVVLAVYLA FIVYLIMRNT SLYSRLRSAM TKST
