ID   NRAM3_ORYSJ             Reviewed;         550 AA.
AC   Q653V6;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Metal transporter Nramp3;
DE            Short=OsNramp3;
GN   Name=NRAMP3; OrderedLocusNames=Os06g0676000, LOC_Os06g46310;
GN   ORFNames=B1153E06.4, OsJ_22349;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Probable metal transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NRAMP (TC 2.A.55) family. {ECO:0000305}.
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DR   EMBL; AP004989; BAD45911.1; -; Genomic_DNA.
DR   EMBL; AP014962; BAS99105.1; -; Genomic_DNA.
DR   EMBL; CM000143; EAZ38005.1; -; Genomic_DNA.
DR   EMBL; AK070574; BAG92038.1; -; mRNA.
DR   RefSeq; XP_015644306.1; XM_015788820.1.
DR   RefSeq; XP_015644307.1; XM_015788821.1.
DR   AlphaFoldDB; Q653V6; -.
DR   SMR; Q653V6; -.
DR   STRING; 4530.OS06T0676000-01; -.
DR   PaxDb; Q653V6; -.
DR   PRIDE; Q653V6; -.
DR   EnsemblPlants; Os06t0676000-01; Os06t0676000-01; Os06g0676000.
DR   GeneID; 9267339; -.
DR   Gramene; Os06t0676000-01; Os06t0676000-01; Os06g0676000.
DR   KEGG; osa:9267339; -.
DR   eggNOG; KOG1291; Eukaryota.
DR   HOGENOM; CLU_020088_0_1_1; -.
DR   InParanoid; Q653V6; -.
DR   OMA; QCLCAKL; -.
DR   OrthoDB; 666470at2759; -.
DR   Proteomes; UP000000763; Chromosome 6.
DR   Proteomes; UP000007752; Chromosome 6.
DR   Proteomes; UP000059680; Chromosome 6.
DR   ExpressionAtlas; Q653V6; baseline and differential.
DR   Genevisible; Q653V6; OS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   HAMAP; MF_00221; NRAMP; 1.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706; PTHR11706; 1.
DR   Pfam; PF01566; Nramp; 1.
DR   PRINTS; PR00447; NATRESASSCMP.
DR   TIGRFAMs; TIGR01197; nramp; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..550
FT                   /note="Metal transporter Nramp3"
FT                   /id="PRO_0000405568"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        473..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..550
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   550 AA;  59708 MW;  4A0905AB3BF18415 CRC64;
     MSGPMQRSSQ PQFISSVERN NQSNGPGTPL IDSIDVDQIV IPEKNSWKNL FSYIGPGFLV
     SIAYIDPGNF ETDLQAGAQY KYELLWIILI ASCAALIIQS LAARLGVVTG KHLAEHCRAE
     YPKATNFILW ILAELAVVAC DIPEVIGTAF ALNMLFKIPV WCGVLITGLS TLMLLLLQQY
     GVRKLEFLIA ILVSLIATCF LVELGYSKPN SSEVVRGLFV PELKGNGATG LAISLLGAMV
     MPHNLFLHSA LVLSRKVPRS VHGIKEACRF YMIESAFALT IAFLINISII SVSGAVCGSD
     NLSPEDQMNC SDLDLNKASF LLKNVLGNWS SKLFAVALLA SGQSSTITGT YAGQYVMQGF
     LDLRMTPWIR NLLTRSLAIL PSLIVSIIGG SSAAGQLIII ASMILSFELP FALVPLLKFT
     SSRTKMGQHT NSKAISVITW GIGSFIVVIN TYFLITSFVK LLLHNGLSTV SQVFSGIFGF
     LGMLIYMAAI LYLVFRKNRK ATLPLLEGDS TVRIVGRDTA TEGEGSLGHL PREDISSMQL
     PQQRTASDLD