NRAM5_ORYSJ
ID NRAM5_ORYSJ Reviewed; 538 AA.
AC Q8H4H5;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Metal transporter Nramp5;
GN Name=NRAMP5; OrderedLocusNames=Os07g0257200, LOC_Os07g15370;
GN ORFNames=OJ1057_E05.110;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Probable metal transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NRAMP (TC 2.A.55) family. {ECO:0000305}.
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DR EMBL; AP004176; BAC21413.1; -; Genomic_DNA.
DR EMBL; AP008213; BAF21226.1; -; Genomic_DNA.
DR EMBL; AP014963; BAT00873.1; -; Genomic_DNA.
DR EMBL; AK070788; BAG92143.1; -; mRNA.
DR RefSeq; XP_015645014.1; XM_015789528.1.
DR AlphaFoldDB; Q8H4H5; -.
DR SMR; Q8H4H5; -.
DR STRING; 4530.OS07T0257200-01; -.
DR TCDB; 2.A.55.2.19; the metal ion (mn(2+)-iron) transporter (nramp) family.
DR PaxDb; Q8H4H5; -.
DR PRIDE; Q8H4H5; -.
DR EnsemblPlants; Os07t0257200-01; Os07t0257200-01; Os07g0257200.
DR GeneID; 4342859; -.
DR Gramene; Os07t0257200-01; Os07t0257200-01; Os07g0257200.
DR KEGG; osa:4342859; -.
DR eggNOG; KOG1291; Eukaryota.
DR HOGENOM; CLU_020088_0_1_1; -.
DR InParanoid; Q8H4H5; -.
DR OMA; WGINSAM; -.
DR OrthoDB; 666470at2759; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR ExpressionAtlas; Q8H4H5; baseline and differential.
DR Genevisible; Q8H4H5; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..538
FT /note="Metal transporter Nramp5"
FT /id="PRO_0000405570"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 518..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 538 AA; 58498 MW; B07763D611234327 CRC64;
MEIERESSER GSISWRASAA HDQDAKKLDA DDQLLMKEPA WKRFLAHVGP GFMVSLAYLD
PGNLETDLQA GANHRYELLW VILIGLIFAL IIQSLAANLG VVTGRHLAEI CKSEYPKFVK
IFLWLLAELA VIAADIPEVI GTAFAFNILF HIPVWVGVLI TGTSTLLLLG LQKYGVRKLE
FLISMLVFVM AACFFGELSI VKPPAKEVMK GLFIPRLNGD GATADAIALL GALVMPHNLF
LHSALVLSRK TPASVRGIKD GCRFFLYESG FALFVALLIN IAVVSVSGTA CSSANLSQED
ADKCANLSLD TSSFLLKNVL GKSSAIVYGV ALLASGQSST ITGTYAGQYI MQGFLDIRMR
KWLRNLMTRT IAIAPSLIVS IIGGSRGAGR LIIIASMILS FELPFALIPL LKFSSSKSKM
GPHKNSIYII VFSWFLGLLI IGINMYFLST SFVGWLIHND LPKYANVLVG AAVFPFMLVY
IVAVVYLTIR KDSVVTFVAD SSLAAVVDAE KADAGDLAVD DDEPLPYRDD LADIPLPR
