ID   NRARP_XENLA             Reviewed;         114 AA.
AC   Q5U5A6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Notch-regulated ankyrin repeat-containing protein;
GN   Name=nrarp;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, INDUCTION, SUBUNIT, AND DEVELOPMENTAL STAGE.
RX   PubMed=11485984; DOI=10.1101/gad.908101;
RA   Lamar E., Deblandre G., Wettstein D., Gawantka V., Pollet N., Niehrs C.,
RA   Kintner C.;
RT   "Nrarp is a novel intracellular component of the Notch signaling pathway.";
RL   Genes Dev. 15:1885-1899(2001).
CC   -!- FUNCTION: Promotes loss of intracellular domain (ICD) of Notch1 in
CC       embryos. By down-regulating ICD levels, could function as a negative
CC       feedback regulator of Notch signaling that attenuates ICD-mediated
CC       transcription (PubMed:11485984). Involved in angiogenesis. May be
CC       involved in somitogenesis (By similarity).
CC       {ECO:0000250|UniProtKB:Q7T3Y0, ECO:0000250|UniProtKB:Q91ZA8,
CC       ECO:0000269|PubMed:11485984}.
CC   -!- SUBUNIT: Forms a ternary complex with the intracellular domain (ICD) of
CC       notch1 and rbpj/suh. {ECO:0000269|PubMed:11485984}.
CC   -!- DEVELOPMENTAL STAGE: Detected at late gastrulae stages within the
CC       prospective trigeminal placodes, followed soon in the posterior neural
CC       plate where the differentiation of primary neurons occurs. Expression
CC       is associated with neurogenesis throughout neural development.
CC       Expressed in a ring of tissue that will form the early somites in
CC       gastrulating embryos and in a region of paraxial mesoderm called the
CC       tailbud domain, which grows out to give rise to somites in the tail in
CC       later-stage embryos. {ECO:0000269|PubMed:11485984}.
CC   -!- INDUCTION: By Notch signaling via a CBF1/Su(H)/Lag-1 (CSL)-dependent
CC       pathway. {ECO:0000269|PubMed:11485984}.
CC   -!- SIMILARITY: Belongs to the NRARP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC084778; AAH84778.1; -; mRNA.
DR   RefSeq; NP_001088453.1; NM_001094984.1.
DR   RefSeq; XP_018084895.1; XM_018229406.1.
DR   AlphaFoldDB; Q5U5A6; -.
DR   SMR; Q5U5A6; -.
DR   BioGRID; 105397; 1.
DR   IntAct; Q5U5A6; 1.
DR   DNASU; 495317; -.
DR   GeneID; 108698141; -.
DR   GeneID; 495317; -.
DR   KEGG; xla:108698141; -.
DR   KEGG; xla:495317; -.
DR   CTD; 495317; -.
DR   Xenbase; XB-GENE-996962; nrarp.S.
DR   OMA; CSAPQIV; -.
DR   OrthoDB; 1514637at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 108698141; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   1: Evidence at protein level;
KW   ANK repeat; Developmental protein; Notch signaling pathway;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..114
FT                   /note="Notch-regulated ankyrin repeat-containing protein"
FT                   /id="PRO_0000325083"
FT   REPEAT          50..79
FT                   /note="ANK 1"
FT   REPEAT          83..112
FT                   /note="ANK 2"
SQ   SEQUENCE   114 AA;  12638 MW;  7C4C145238688B22 CRC64;
     MSQAEMSTCS MPHTQRVFQE AVRNGNTKEL HSLLQNMTNC EFNVNSFGPE GQTALHQSVI
     DGNLELVKLL VKFGADIRLA NRDGWSALHI AAYGGHQDIV LYLITKAKYS SSSR