ID   NRARP_XENTR             Reviewed;         114 AA.
AC   A4II29;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Notch-regulated ankyrin repeat-containing protein;
GN   Name=nrarp;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes loss of intracellular domain (ICD) of Notch1 in
CC       embryos. By down-regulating ICD levels, could function as a negative
CC       feedback regulator of Notch signaling that attenuates ICD-mediated
CC       transcription (By similarity). Involved in angiogenesis. May be
CC       involved in somitogenesis (By similarity).
CC       {ECO:0000250|UniProtKB:Q5U5A6, ECO:0000250|UniProtKB:Q7T3Y0,
CC       ECO:0000250|UniProtKB:Q91ZA8}.
CC   -!- SUBUNIT: Forms a ternary complex with the intracellular domain (ICD) of
CC       notch1 and rbpj/suh. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NRARP family. {ECO:0000305}.
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DR   EMBL; BC135819; AAI35820.1; -; mRNA.
DR   RefSeq; NP_001096349.1; NM_001102879.1.
DR   AlphaFoldDB; A4II29; -.
DR   SMR; A4II29; -.
DR   STRING; 8364.ENSXETP00000008564; -.
DR   PaxDb; A4II29; -.
DR   DNASU; 100124939; -.
DR   GeneID; 100124939; -.
DR   KEGG; xtr:100124939; -.
DR   CTD; 441478; -.
DR   Xenbase; XB-GENE-996958; nrarp.
DR   eggNOG; KOG0505; Eukaryota.
DR   HOGENOM; CLU_000134_41_1_1; -.
DR   InParanoid; A4II29; -.
DR   OMA; REAKCHS; -.
DR   PhylomeDB; A4II29; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IBA:GO_Central.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IBA:GO_Central.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; IBA:GO_Central.
DR   GO; GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Developmental protein; Notch signaling pathway;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..114
FT                   /note="Notch-regulated ankyrin repeat-containing protein"
FT                   /id="PRO_0000325084"
FT   REPEAT          50..79
FT                   /note="ANK 1"
FT   REPEAT          83..112
FT                   /note="ANK 2"
SQ   SEQUENCE   114 AA;  12613 MW;  1546DE296BAED194 CRC64;
     MSQAEMSTCS TPHTQRVFQE AVRKGNTKEL QSLLQNMTNC EFNVNSFGPE GQTALHQSVI
     DGNLELVKLL VKFGADIRLA NRDGWSALHI AAYGGHQDIV LYLITKAKYS SSSR