ID   NRDE2_DICDI             Reviewed;        1320 AA.
AC   Q54QP0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Nuclear exosome regulator NRDE2 {ECO:0000305};
DE   AltName: Full=Protein NRDE2 homolog {ECO:0000305};
GN   Name=nrde2; ORFNames=DDB_G0283719;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Protein of the nuclear speckles that regulates RNA exosomal
CC       degradation. {ECO:0000250|UniProtKB:Q9H7Z3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q9H7Z3}.
CC   -!- SIMILARITY: Belongs to the NRDE2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000056; EAL65626.1; -; Genomic_DNA.
DR   RefSeq; XP_638983.1; XM_633891.1.
DR   AlphaFoldDB; Q54QP0; -.
DR   STRING; 44689.DDB0238413; -.
DR   PaxDb; Q54QP0; -.
DR   EnsemblProtists; EAL65626; EAL65626; DDB_G0283719.
DR   GeneID; 8624229; -.
DR   KEGG; ddi:DDB_G0283719; -.
DR   dictyBase; DDB_G0283719; -.
DR   eggNOG; KOG1972; Eukaryota.
DR   HOGENOM; CLU_259974_0_0_1; -.
DR   InParanoid; Q54QP0; -.
DR   OMA; YARIITV; -.
DR   PhylomeDB; Q54QP0; -.
DR   PRO; PR:Q54QP0; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:1902369; P:negative regulation of RNA catabolic process; ISS:UniProtKB.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IBA:GO_Central.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR013633; NRDE-2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13471; PTHR13471; 1.
DR   Pfam; PF08424; NRDE-2; 1.
DR   SMART; SM00386; HAT; 4.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..1320
FT                   /note="Nuclear exosome regulator NRDE2"
FT                   /id="PRO_0000343143"
FT   REPEAT          348..380
FT                   /note="HAT 1"
FT   REPEAT          428..467
FT                   /note="HAT 2"
FT   REPEAT          864..899
FT                   /note="HAT 3"
FT   REPEAT          1221..1254
FT                   /note="HAT 4"
FT   REPEAT          1256..1288
FT                   /note="HAT 5"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          74..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          598..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          676..716
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1056..1078
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          146..186
FT                   /evidence="ECO:0000255"
FT   COILED          591..699
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        31..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..119
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..136
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        688..704
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1320 AA;  154029 MW;  78F491E0BD2352D9 CRC64;
     MSHSKKSLFA AYSNDDDGDG DGDDLYLEEH QKVTSTNTPS SSWFSNSSYK EKQENVIDTV
     TSKTQLKRAS DFFNLDSDNT FSSPPPPSSS PPLYSKTEKK NNDKVKIIMK KRSFIDSSSD
     DNSDDDDNDS SSSDQDSSDD DSGGFTYNRK KYKKEQQQQE NEENEENERK NRKKEKKKKR
     KDKKFKNDDK SMMIISNENS ENYSDNSSYF IEKTGDKVFS SRTSTPNYNY DNSFILGMSD
     YKIGFSKKEG YQIEPISLTS FNKQQINNRY FTKPSSSSSS SSQSQQQLIT VITKRKEIEE
     IEKVKPISNI KDPSKSNDDE IKLIVLNENN HDNDDDDNDD DDNETLERKT LKKNSELNKL
     VEQYPNNIEY WIDLVKFQEN FQQFSRNVNK SKTSMYEKQL SIYRNSLLHN PDSEILTIEY
     LKLASKLWDQ QKVLDLWNKV LSSSSSSSSS SIISEKLWKE YIEFCLSNFN DFKIEKIKET
     IITIIRKMLV KRRSFKVKDY NFMENISNLE ESILQFISQL SKLLNQAGFS ERVIGIYQSL
     IEFNCFEPIQ LSNETQATLL KEFKSYWSSL DYPKIGNPNS IGWSKSFTIL LNNSINNNNN
     KNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN MDLDNLDNLS IEEIEKLLKE
     QEDQENQDNE NIFNITHKSK DLNEDDDNEN NNNNQEEQED NDSNSNDNDN NNNKFNTWGK
     KEIELDELKW KPLDINNNLE VNKEVNENDT ERVVLFNDFY ELLFRFVKEE NKLELVFQFL
     EFLGVPISLL DDKIQPRYSF YHPQRRDSIN SIHNENIISL LFKDLKQQPS PPSPSPEYPN
     WFKTFDKFSN NNNNSQNLLG LSDDKIKFID SIYKLILENS NGIKLKEKLY VSYIMFKASI
     DINDAKVYTK SLCEKFKNLI YFDIFASLEL KSGKTQQART IYQTTCFYIN QLINQQAQQQ
     QQQLQIDLVY REYLFMELNL IYQTIEKDPQ ILKRFIKSNH KPIELFFTPL HILQCYLDGN
     YKQYSSSTFN LNTINQFLNQ LNLKFLQKLQ QQQQQQQQNS SSSSSSSSSS SSSSSSSSSS
     VDFLLCYCIF ELLSNGFDGF LILFKRITSS STNDYLKIFS IQHELLTIRC IDMVTKIAPL
     IGTDPKRIKN LIIDSLNQYY DHPKLLSLFL NWESKNQLIN RIRIYFDLNS INNINNNNGG
     DDGGSSIFWL FAIKFESNRI GAAQRIKSLF EKAISTTQKH NIIFWKLYIE FEINRGRLKI
     AKSIYYRSIK QLPFSKQIWL LPFTNSKLSL IFNNQEFNEI INLINEKGIR LRILTPKVSN