ID   NRDE2_SCHPO             Reviewed;         972 AA.
AC   O42975;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Protein NRDE2 homolog;
GN   ORFNames=SPBC20F10.05;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-970, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- INTERACTION:
CC       O42975; O94316: cwf10; NbExp=3; IntAct=EBI-9003631, EBI-538866;
CC       O42975; O13799: SPAC17H9.02; NbExp=3; IntAct=EBI-9003631, EBI-8993901;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the NRDE2 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA16845.1; -; Genomic_DNA.
DR   PIR; T39876; T39876.
DR   RefSeq; NP_596369.1; NM_001022290.2.
DR   AlphaFoldDB; O42975; -.
DR   BioGRID; 277216; 57.
DR   IntAct; O42975; 10.
DR   STRING; 4896.SPBC20F10.05.1; -.
DR   iPTMnet; O42975; -.
DR   SwissPalm; O42975; -.
DR   MaxQB; O42975; -.
DR   PaxDb; O42975; -.
DR   PRIDE; O42975; -.
DR   EnsemblFungi; SPBC20F10.05.1; SPBC20F10.05.1:pep; SPBC20F10.05.
DR   GeneID; 2540691; -.
DR   KEGG; spo:SPBC20F10.05; -.
DR   PomBase; SPBC20F10.05; -.
DR   VEuPathDB; FungiDB:SPBC20F10.05; -.
DR   eggNOG; KOG1972; Eukaryota.
DR   HOGENOM; CLU_312419_0_0_1; -.
DR   InParanoid; O42975; -.
DR   OMA; CKEREST; -.
DR   PhylomeDB; O42975; -.
DR   PRO; PR:O42975; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005681; C:spliceosomal complex; EXP:PomBase.
DR   GO; GO:1902369; P:negative regulation of RNA catabolic process; IBA:GO_Central.
DR   GO; GO:1902802; P:regulation of siRNA-dependent facultative heterochromatin assembly; IGI:PomBase.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR013633; NRDE-2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13471; PTHR13471; 1.
DR   Pfam; PF08424; NRDE-2; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..972
FT                   /note="Protein NRDE2 homolog"
FT                   /id="PRO_0000343144"
FT   REPEAT          159..191
FT                   /note="HAT 1"
FT   REPEAT          250..282
FT                   /note="HAT 2"
FT   REPEAT          318..350
FT                   /note="HAT 3"
FT   REPEAT          355..386
FT                   /note="HAT 4"
FT   REPEAT          608..640
FT                   /note="HAT 5"
FT   REPEAT          788..820
FT                   /note="HAT 6"
FT   REPEAT          860..894
FT                   /note="HAT 7"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         970
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   972 AA;  113249 MW;  39EA1551A2C5DD8F CRC64;
     MPSNHNTSVP KFSSFNSVKA KKNPITKSNK KYRSSHDQVS SNHAKSSFPS HRSIQSNFAV
     DTKGEKQNLL YGINKRPVPK YHRSSSSVYG SAPLLRIVKE SKEGITLNKK KSLEIKYDEE
     RSFDEKENDE SEFEDGQQGF IPLLVNRNSD PSEKSTFSLN ILKAIKETDE EIKKNPGKAR
     LWIKMCEYQE RLLFDEFRRS NSDDIKGKLK IENNSRSVKL SILEKALKEV KGCDHEILVS
     YYLQLGSEEW SKEETNQKFE EVLIEHPGYL NLWMKYAEYF TGISEFTFND CLNMFSKCFK
     FLKQKLSDRK SCKERESTDV TSNFEVEEAI LHLLIRLCDF LKNCGYYELA WSIFQANMEL
     CYFYPRYLEK KLDSTFFESF SKFWNSDTPK FSEENARGWC NVLDDESSQQ NQNFSSEIGI
     FQTVKLWYLN ESKFDTNPPP RSTMSCRKLS GIDDPFRYIV FNDIQDFIVC FESETIAFAF
     KYKFFAFCGV PLFPPGISTN SWFASYDKGI YNLLFGMASS ESFINGQIAE KNSFQFPCSI
     LPSYIDLFIS LMSFKNLNFK LFDYNLAHHV KESMERAFHQ LVFSADDEYL ASVYLIYLKQ
     METKNLSEEK PQVNKIVKKI LKKYDSSVSV WNTYAQLEHL SGAFTMAETI FKTIFQIHAS
     QLRYIDNLNV YKNWAFRKLL INDTEGCLVI IKCLLFPGDK SLTSDNNRAS EMLFGMLENC
     ASKEELLYVC LIYTIWTHCT DMDSMDNCVY LCIQKFESYG WGASSEMECY FSYCSLIFYY
     QATTLQFYNL PKVRPFFEKG VTLFSANTAI WEVYIFFESK LRQENKPKIR AMKILKSASN
     AVVTACWYLF YVAVQQIEPT NSQYFLRTLD ITLNNEKLKS VAKFWRIYLK ILNLRLNGTE
     WVSAITTKAL ASCPCNKGVC MDVIDLLLKK EMESRAIICY IIMLEKGFRV HNEIRRDVLK
     FERGDELILS PN