ID   NRDH_ECO57              Reviewed;          81 AA.
AC   P0AC67; Q47414;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Glutaredoxin-like protein NrdH;
GN   Name=nrdH; OrderedLocusNames=Z3975, ECs3536;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Electron transport system for the ribonucleotide reductase
CC       system NrdEF. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glutaredoxin family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG57783.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36959.1; -; Genomic_DNA.
DR   PIR; C85915; C85915.
DR   PIR; H91070; H91070.
DR   RefSeq; NP_311563.1; NC_002695.1.
DR   RefSeq; WP_001223227.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AC67; -.
DR   SMR; P0AC67; -.
DR   STRING; 155864.EDL933_3839; -.
DR   EnsemblBacteria; AAG57783; AAG57783; Z3975.
DR   EnsemblBacteria; BAB36959; BAB36959; ECs_3536.
DR   GeneID; 67414033; -.
DR   GeneID; 914748; -.
DR   KEGG; ece:Z3975; -.
DR   KEGG; ecs:ECs_3536; -.
DR   PATRIC; fig|386585.9.peg.3690; -.
DR   eggNOG; COG0695; Bacteria.
DR   HOGENOM; CLU_026126_9_0_6; -.
DR   OMA; PACVQCD; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0097573; F:glutathione oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   InterPro; IPR011909; GlrX_NrdH.
DR   InterPro; IPR002109; Glutaredoxin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF00462; Glutaredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02194; GlrX_NrdH; 1.
DR   PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Electron transport; Redox-active center;
KW   Reference proteome; Transport.
FT   CHAIN           1..81
FT                   /note="Glutaredoxin-like protein NrdH"
FT                   /id="PRO_0000141639"
FT   DOMAIN          1..81
FT                   /note="Glutaredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00686"
FT   DISULFID        11..14
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   81 AA;  9139 MW;  6D0878E9CD133137 CRC64;
     MRITIYTRND CVQCHATKRA MENRGFDFEM INVDRVPEAA EALRAQGFRQ LPVVIAGDLS
     WSGFRPDMIN RLHPAPHAAS A